Match!
Joshua M. Schmidt
Max Planck Society
12Publications
7H-index
392Citations
Publications 12
Newest
#1Paul Battlay (University of Melbourne)H-Index: 5
#2Pontus B. Leblanc (University of Melbourne)H-Index: 2
Last.Charles Robin (University of Melbourne)H-Index: 20
view all 7 authors...
Patterns of nucleotide polymorphism within populations of Drosophila melanogaster suggest that insecticides have been the selective agents driving the strongest recent bouts of positive selection. However, there is a need to explicitly link selective sweeps to the particular insecticide phenotypes that could plausibly account for the drastic selective responses that are observed in these non-target insects. Here, we screen the Drosophila Genetic Reference Panel with two common insecticides; mala...
#1Felix M. Key (MPG: Max Planck Society)H-Index: 9
#2Muslihudeen A. Abdul-Aziz (MPG: Max Planck Society)H-Index: 5
Last.Aida M. Andrés (MPG: Max Planck Society)H-Index: 24
view all 9 authors...
Ambient temperature is a critical environmental factor for all living organisms. It was likely an important selective force as modern humans recently colonized temperate and cold Eurasian environments. Nevertheless, as of yet we have limited evidence of local adaptation to ambient temperature in populations from those environments. To shed light on this question, we exploit the fact that humans are a cosmopolitan species that inhabit territories under a wide range of temperatures. Focusing on co...
#1Battlay (University of Melbourne)H-Index: 1
#2Llewellyn Green (University of Melbourne)H-Index: 3
Last.Charles Robin (University of Melbourne)H-Index: 20
view all 6 authors...
Patterns of nucleotide polymorphism within populations of Drosophila melanogaster suggest that insecticides have been the selective agents driving the strongest recent bouts of positive selection. However, there is a need to explicitly link selective sweep loci to the particular insecticide phenotypes that could plausibly account for the drastic selective responses that are observed in these non-target insects. Here, we screen the Drosophila Genetic Reference Panel with two common insecticides; ...
#1Bárbara Domingues Bitarello (USP: University of São Paulo)H-Index: 5
#2Cesare de Filippo (MPG: Max Planck Society)H-Index: 16
Last.Aida M. Andrés (MPG: Max Planck Society)H-Index: 24
view all 7 authors...
#1Felix M. Key (MPG: Max Planck Society)H-Index: 9
#2Muslihudeen A. Abdul-Aziz (University of Adelaide)H-Index: 5
Last.Aida M. Andrés (MPG: Max Planck Society)H-Index: 24
view all 9 authors...
Ambient temperature is a critical environmental factor for all living organisms. It was likely an important selective force as modern humans recently colonized temperate and cold Eurasian environments. Nevertheless, as of yet we have limited evidence of local adaptation to ambient temperature in populations from those environments. To shed light on this question, we exploit the fact that humans are a cosmopolitan species that inhabits territories under a wide range of temperatures. Focusing on c...
#1Joshua M. Schmidt (MPG: Max Planck Society)H-Index: 7
#2Paul Battlay (University of Melbourne)H-Index: 5
Last.Charles Robin (University of Melbourne)H-Index: 20
view all 7 authors...
Insecticide resistance is considered a classic model of microevolution, where a strong selective agent is applied to a large natural population, resulting in a change in frequency of alleles that confer resistance. While many insecticide resistance variants have been characterized at the gene level, they are typically single genes of large effect identified in highly resistant pest species. In contrast, multiple variants have been implicated in DDT resistance in Drosophila melanogaster ; however...
#1Marc de Manuel (Barcelona Biomedical Research Park)H-Index: 5
#2Martin Kuhlwilm (Barcelona Biomedical Research Park)H-Index: 8
Last.Tomas Marques-Bonet (Barcelona Biomedical Research Park)H-Index: 48
view all 37 authors...
Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa. We found that chimpanzee population substructure makes genetic information a good predictor of geographic origin at country and regional scales. Multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200,000 and 550,0...
#1Paul Battlay (University of Melbourne)H-Index: 5
#2Joshua M. Schmidt (University of Melbourne)H-Index: 7
Last.Charles Robin (University of Melbourne)H-Index: 20
view all 4 authors...
Scans of the Drosophila melanogaster genome have identified organophosphate resistance loci among those with the most pronounced signature of positive selection. In this study, the molecular basis of resistance to the organophosphate insecticide azinphos-methyl was investigated using the Drosophila Genetic Reference Panel, and genome-wide association. Recently released full transcriptome data were used to extend the utility of the Drosophila Genetic Reference Panel resource beyond traditional ge...
#1Alexandre Fournier-Level (University of Melbourne)H-Index: 15
#2Adina Neumann‐Mondlak (University of Melbourne)H-Index: 1
Last.Charles Robin (University of Melbourne)H-Index: 20
view all 6 authors...
Insecticide resistance evolves extremely rapidly, providing an illuminating model for the study of adaptation. With climate change reshaping species distribution, pest and disease vector control needs rethinking to include the effects of environmental variation and insect stress physiology. Here, we assessed how both long-term adaptation of populations to temperature and immediate temperature variation affect the genetic architecture of DDT insecticide response in Drosophila melanogaster. Mortal...
#1Emily J. Remnant (USYD: University of Sydney)H-Index: 8
#2Robert T. Good (University of Melbourne)H-Index: 21
Last.Philip Batterham (University of Melbourne)H-Index: 33
view all 7 authors...
The Resistance to Dieldrin gene, Rdl, encodes a GABA-gated chloride channel subunit that is targeted by cyclodiene and phenylpyrazole insecticides. The gene was first characterized in Drosophila melanogaster by genetic mapping of resistance to the cyclodiene dieldrin. The 4,000-fold resistance observed was due to a single amino acid replacement, Ala301 to Ser. The equivalent change was subsequently identified in Rdl orthologs of a large range of resistant insect species. Here, we report identifi...
12