Alan Jackson
University of Manchester
Publications 911
#1Jurgen Peerlings (Maastricht University Medical Centre)H-Index: 6
#2Henry C. Woodruff (Maastricht University Medical Centre)H-Index: 12
Last.Philippe Lambin (Maastricht University Medical Centre)H-Index: 81
view all 11 authors...
Quantitative radiomics features, extracted from medical images, characterize tumour-phenotypes and have been shown to provide prognostic value in predicting clinical outcomes. Stability of radiomics features extracted from apparent diffusion coefficient (ADC)-maps is essential for reliable correlation with the underlying pathology and its clinical applications. Within a multicentre, multi-vendor trial we established a method to analyse radiomics features from ADC-maps of ovarian (n = 12), lung (...
5 CitationsSource
#1Ryan Pathak (University of Manchester)H-Index: 2
#2Jingduo Tian (University of Manchester)
Last.Alan JacksonH-Index: 86
view all 8 authors...
ADC is a potential post treatment imaging biomarker in colorectal liver metastasis however measurements are affected by respiratory motion. This is compounded by increased statistical uncertainty in ADC measurement with decreasing tumour volume. In this prospective study we applied a retrospective motion correction method to improve the image quality of 15 tumour data sets from 11 patients. We compared repeatability of ADC measurements corrected for motion artefact against non-motion corrected a...
#2Gordon C Jayson (University of Manchester)H-Index: 58
Last.Mark P SaundersH-Index: 31
view all 19 authors...
Abstract Background The DREAMtherapy (Dual REctal Angiogenesis MEK inhibition radiotherapy) trial is a novel intertwined design whereby two tyrosine kinase inhibitors (cediranib and selumetinib) were independently evaluated with rectal chemoradiotherapy (CRT) in an efficient manner to limit the extended follow-up period often required for radiotherapy studies. Patients and methods Cediranib or selumetinib was commenced 10 days before and then continued with RT (45 Gy/25#/5 wks) and capecitabine ...
#1Sunhea Choi (University of Southampton)H-Index: 1
#2Ho Ming Yuen (University of Southampton)H-Index: 10
Last.Ann Ashworth (Lond: University of London)H-Index: 36
view all 10 authors...
Background Scaling up improved management of severe acute malnutrition (SAM) has been identified as the nutrition intervention with the greatest potential to reduce child mortality but it requires improved operational capacity. Objective To investigate whether an eLearning course, which can be used at scale in resource-poor countries, leads to improved diagnosis, clinical management and survival of children with SAM. Design A 2-year preintervention and postintervention study between January 2015...
#2Shane McKie (University of Manchester)H-Index: 28
Last.Ian N. BruceH-Index: 61
view all 7 authors...
Objectives Cognitive dysfunction (CD) is common in systemic lupus erythematosus (SLE) but the cause remains unclear and treatment options are limited. We aimed to compare cognitive function in SLE and healthy controls (HCs) using both behavioural and neuroimaging techniques. Methods Patients with SLE with stable disease and HCs were recruited. Clinical and psychological data were collected along with a blood sample for relevant biomarkers. Neurocognitive function was assessed using tests from th...
1 CitationsSource
#1Jose Anton-Rodriguez (University of Manchester)H-Index: 7
#2Peter J JulyanH-Index: 19
Last.Julian C. Matthews (University of Manchester)H-Index: 25
view all 7 authors...
We compared a conventional PET-CT scanner (Siemens Biograph TruePoint TrueV) with and without resolution modeling (RM) image reconstruction with a high resolution research tomograph (HRRT) in order to assess the utility of conventional scanners for brain scanning. A modified Esser phantom and 6 neurofibromatosis 2 (NF2) patients with vestibular schwannomas (VS) were scanned using both scanners. The phantom was filled with fluorine-18 (40 MBq, 4:1 contrast ratio) and scanned for 60 min on separat...
#1Ahmed Salem (University of Manchester)H-Index: 7
#2Ross Little (University of Manchester)H-Index: 6
Last.James P B O'Connor (University of Manchester)H-Index: 27
view all 20 authors...
Purpose: Hypoxia is associated with poor prognosis and is predictive of poor response to cancer treatments, including radiotherapy. Developing noninvasive biomarkers that both detect hypoxia prior to treatment and track change in tumor hypoxia following treatment is required urgently. Experimental Design: We evaluated the ability of oxygen-enhanced MRI (OE-MRI) to map and quantify therapy-induced changes in tumor hypoxia by measuring oxygen-refractory signals in perfused tissue (perfused Oxy-R)....
#1Victor O. Owino (IAEA: International Atomic Energy Agency)H-Index: 13
#2Alexia A.J. Murphy-Alford (IAEA: International Atomic Energy Agency)
Last.Alan Jackson (Southampton General Hospital)H-Index: 86
view all 7 authors...
Severe and moderate acute malnutrition are among the leading causes of mortality among children in low‐ and middle‐income countries. There is strong evidence that growth assessed anthropometrically from conception to 2 years of age marks later risk of ill health. This is central to the concept of the developmental origins of adult disease and is presumed to be related to modification of developmental processes during critical “window(s)” of vulnerability. Interventions to treat acute malnutritio...