Raed A. Alharbi
University of Surrey
Publications 3
#1Raed A. AlharbiH-Index: 2
#2Hardev PandhaH-Index: 46
Last.Richard MorganH-Index: 25
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The HOX genes encode a family of transcription factors that have key roles in both development and malignancy. Disrupting the interaction between HOX proteins and their binding partner, PBX, has been shown to cause apoptotic cell death in a range of solid tumors. However, despite HOX proteins playing a particularly significant role in acute myeloid leukemia (AML), the relationship between HOX gene expression and patient survival has not been evaluated (with the exception of HOXA9), and the mecha...
12 CitationsSource
#1Raed A. Alharbi (University of Surrey)H-Index: 2
#2Ruth Pettengell (Lond: University of London)
Last.Richard Morgan (University of Bradford)H-Index: 25
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The molecular mechanisms underlying the pathogenesis of acute myeloid leukemia (AML) have been extensively studied, and are known to involve members of the HOX family of transcription factors, both as partners in chimeric fusion proteins, and also in their wild type form. However, the role of HOX proteins in the survival of AML cells has proved difficult to assess as many have redundant functions, which makes a conventional knock down experiment difficult to interpret. An alternative strategy to...
#1Raed A. AlharbiH-Index: 2
#2Ruth PettengellH-Index: 39
Last.Richard MorganH-Index: 25
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The homeobox (HOX) genes are a highly conserved family of homeodomain-containing transcription factors that specify cell identity in early development and, subsequently, in a number of adult processes including hematopoiesis. The dysregulation of HOX genes is associated with a number of malignancies including acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), where they have been shown to support the immortalization of leukemic cells both as chimeric partners in fusion genes and whe...
138 CitationsSource