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Noel Janney
Scripps Research Institute
Recombination-activating geneV(D)J recombinationGene familyLocus (genetics)Ectopic expression
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#1Peter GoebelH-Index: 4
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Accessibility of immunoglobulin (Ig) gene segments to V(D)J recombination is highly regulated and is normally only achieved in B cell precursors. We previously showed that ectopic expression of E2A or early B cell factor (EBF) with recombination activating gene (RAG) induces rearrangement of IgH and IgL genes in nonlymphoid cells. VκI genes throughout the locus were induced to rearrange after transfection with E2A, suggesting that the entire Vκ locus was accessible. However, here we show that Ig...
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