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Yiheng Tu
Harvard University
PsychologyNeuroscienceFunctional magnetic resonance imagingElectroencephalographyResting state fMRI
37Publications
7H-index
184Citations
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Publications 41
Newest
#1Lili Zhou (CAS: Chinese Academy of Sciences)
#2Yanzhi Bi (CAS: Chinese Academy of Sciences)
Last. Li Hu (CAS: Chinese Academy of Sciences)H-Index: 24
view all 10 authors...
Clinical observations showed that schizophrenia (SCZ) patients reported little or no pain under various conditions that are commonly associated with intense painful sensations, leading to a higher risk of morbidity and mortality. However, this phenomenon has received little attention and its underlying neural mechanisms remain unclear. Here, we conducted two experiments combining psychophysics, electroencephalography (EEG), and functional magnetic resonance imaging (fMRI) techniques to investiga...
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#1Yiheng TuH-Index: 7
#2Fang ZengH-Index: 14
Last. Courtney LangH-Index: 6
view all 16 authors...
Objective To identify and validate an fMRI-based neural marker for migraine without aura (MwoA) and to examine its association with treatment response. Methods We conducted cross-sectional studies with resting-state fMRI data from 230 participants and machine learning analyses. In studies 1 through 3, we identified, cross-validated, independently validated, and cross-sectionally validated an fMRI-based neural marker for MwoA. In study 4, we assessed the relationship between the neural marker and...
1 CitationsSource
#1Yiheng Tu (Harvard University)H-Index: 7
#2Yanzhi Bi (CAS: Chinese Academy of Sciences)
Last. Li Hu (CAS: Chinese Academy of Sciences)H-Index: 24
view all 5 authors...
Expectation interacting with nociceptive input can shape the perception of pain. It has been suggested that reward-related expectations are associated with the activation of the ventral tegmental area (VTA), which projects to the striatum (e.g., nucleus accumbens [NAc]) and prefrontal cortex (e.g., rostral anterior cingulate cortex [rACC]). However, the role of these projection pathways in encoding expectancy effects on pain remains unclear. In this study, we leveraged a visual cue conditioning ...
1 CitationsSource
#1Jiao Liu (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 7
#2Lidian Chen (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 15
Last. Jian Kong (Harvard University)H-Index: 45
view all 18 authors...
Abstract Objectives Knee osteoarthritis (KOA) is a common degenerative joint disease with no satisfactory intervention. Recently, both physical and mindfulness exercises have received considerable attention for their implications in KOA pain management, and the dorsolateral prefrontal cortex (DLPFC) has displayed a critical role in pain modulation. This study aimed to comparatively investigate the modulation effects of different exercises using multidisciplinary measurements. Methods 140 KOA pat...
1 CitationsSource
#1Binlong Zhang (Harvard University)H-Index: 2
#2Minyoung Jung (Harvard University)H-Index: 8
Last. Jian Kong (Harvard University)H-Index: 45
view all 18 authors...
Abstract Background Previous studies have found widespread pain processing alterations in the brain in chronic low back pain (cLBP) patients. We aimed to (1) identify brain regions showing altered amplitude of low-frequency fluctuations (ALFF) using MRI and use these regions to discriminate cLBP patients from healthy controls (HCs) and (2) identify brain regions that are sensitive to cLBP pain intensity changes. Methods We compared ALFF differences by MRI between cLBP subjects (90) and HCs (74),...
3 CitationsSource
#1Yiheng Tu (Harvard University)H-Index: 7
#2Binlong Zhang (Harvard University)H-Index: 2
Last. Jian Kong (Harvard University)H-Index: 45
view all 6 authors...
Abstract Individuals are unique in terms of brain and behavior. Some are very sensitive to pain, while others have a high tolerance. However, how inter-individual intrinsic differences in the brain are related to pain is unknown. Here, we performed longitudinal test-retest analyses to investigate pain threshold variability among individuals using a resting-state fMRI brain connectome. Twenty-four healthy subjects who received four MRI sessions separated by at least 7 days were included in the da...
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#1Jin Cao (Beijing University of Chinese Medicine)H-Index: 2
#2Yiheng Tu (Harvard University)H-Index: 7
Last. Jian Kong (Harvard University)H-Index: 45
view all 9 authors...
2 CitationsSource
#1Yiheng TuH-Index: 7
#2Zening FuH-Index: 8
Last. Jian KongH-Index: 45
view all 13 authors...
Objective To investigate the dynamic functional connectivity of thalamocortical networks in interictal migraine patients and whether clinical features are associated with abnormal connectivity. Methods We investigated dynamic functional network connectivity (dFNC) of the migraine brain in 89 interictal migraine patients and 70 healthy controls. We focused on the temporal properties of thalamocortical connectivity using sliding window cross-correlation, clustering state analysis, and graph-theory...
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#1Minyoung Jung (University of Fukui)H-Index: 8
#2Yiheng Tu (Harvard University)H-Index: 7
Last. Jian Kong (Harvard University)H-Index: 45
view all 7 authors...
Background Both attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are neurodevelopmental disorders with a high prevalence. They are often comorbid and both exhibit abnormalities in sustained attention, yet common and distinct neural patterns of ASD and ADHD remain unidentified. Aims To investigate shared and distinct functional connectivity patterns in a relatively large sample of boys (7- to 15-year-olds) with ADHD, ASD and typical development matched by age, ge...
2 CitationsSource
#1Yiheng TuH-Index: 7
#2Minyoung JungH-Index: 8
Last. Jian KongH-Index: 45
view all 15 authors...
AbstractAccumulating evidence has shown that complicated brain systems are involved in the development and maintenance of chronic low back pain (cLBP), but the association between brain functional changes and clinical outcomes remains unclear. Here, we used resting-state functional magnetic resonanc
5 CitationsSource
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