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Frederick R. Maxfield
Cornell University
EndosomeEndocytosisBiochemistryBiologyCell biology
282Publications
85H-index
23.3kCitations
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Publications 282
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#1David B. Iaea (Cornell University)H-Index: 6
#2Zachary R. Spahr (Cornell University)
Last. Frederick R. Maxfield (Cornell University)H-Index: 85
view all 10 authors...
Abstract STARD4, a member of the evolutionarily conserved START gene family, is a soluble sterol transport protein implicated in cholesterol sensing and maintenance of cellular homeostasis. STARD4 is widely expressed and has been shown to transfer sterol between liposomes as well as organelles in cells. However, STARD4 knockout mice lack an obvious phenotype, so the overall role of STARD4 is unclear. To model long term depletion of STARD4 in cells, we use short hairpin RNA technology to stably d...
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#1Rajesh K. Singh (Cornell University)H-Index: 6
#2Abigail S. Haka (Cornell University)H-Index: 19
Last. Frederick R. Maxfield (Cornell University)H-Index: 85
view all 9 authors...
Objective: Aggregation and modification of LDLs (low-density lipoproteins) promote their retention and accumulation in the arteries. This is a critical initiating factor during atherosclerosis. Mac...
3 CitationsSource
#1Frederick R. Maxfield (Cornell University)H-Index: 85
#2Valéria C. Barbosa-Lorenzi (Cornell University)H-Index: 6
Last. Rajesh K. Singh (Cornell University)H-Index: 6
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Mammalian phagocytes carry out several essential functions, including killing and digesting infectious organisms, clearing denatured proteins, removing dead cells and removing several types of debris from the extracellular space. Many of these functions involve phagocytosis, the engulfment of a target in a specialized endocytic process and then fusion of the new phagosome with lysosomes. Phagocytes such as macrophages can phagocytose targets that are several micrometers in diameter (eg, dead cel...
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Last. Rajesh K. SinghH-Index: 6
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#1Jessica Davidson (WashU: Washington University in St. Louis)H-Index: 1
#2Elizabeth Molitor (WashU: Washington University in St. Louis)H-Index: 2
Last. Daniel S. OryH-Index: 46
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Abstract Niemann-Pick type C1 (NPC1) disease is a fatal neurovisceral disease for which there are no FDA approved treatments, though cyclodextrin (HPβCD) slows disease progression in preclinical models and in an early phase clinical trial. Our goal was to evaluate the mechanism of action of a previously described combination-therapy, Triple Combination Formulation (TCF) – comprised of the histone deacetylase inhibitor (HDACi) vorinostat/HPβCD/PEG – shown to prolong survival in Npc1 mice. In thes...
2 CitationsSource
#1Suzanne R. Pfeffer (Stanford University)H-Index: 51
#2Frederick R. Maxfield (Cornell University)H-Index: 85
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#1Julia Tcw (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 5
#2Shuang A. Liang (UCI: University of California, Irvine)
Last. Alison Goate (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 114
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Apolipoprotein E (APOE) e4 is the strongest genetic risk factor for Alzheimer9s disease (AD). Although its association with AD is well-established, the impact of APOE e4 on human brain cell function remains unclear. Here we investigated the effects of APOE e4 on several brain cell types derived from human induced pluripotent stem cells and human APOE targeted replacement mice. Gene set enrichment and pathway analyses of whole transcriptome profiles showed that APOE e4 is associated with dysregul...
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#1Dana L. Cruz (Cornell University)H-Index: 4
#2Mukarram El-Banna (RU: Rutgers University)
Last. Frederick R. Maxfield (Cornell University)H-Index: 85
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Alzheimers disease (AD) is characterized by the accumulation of amyloid plaques surrounded by microglia. In cell culture, microglia internalize fibrillar {beta}-amyloid but do not degrade it efficiently. Unactivated microglia have a relatively high lysosomal pH, which impairs the activity of lysosomal proteases. Previous studies showed that activation of microglia with macrophage colony stimulating factor decreases lysosomal pH and enhances fibrillar {beta}-amyloid degradation. We investigated t...
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#1Lynda M. PieriniH-Index: 18
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#1Rajesh K. Singh (Cornell University)H-Index: 6
#2Abigail S. Haka (Cornell University)H-Index: 19
Last. Frederick R. Maxfield (Cornell University)H-Index: 85
view all 9 authors...
Aggregation and modification of low-density lipoproteins (LDL) promotes their retention and accumulation in the arteries. This is a critical initiating factor during atherosclerosis. Macrophage catabolism of aggregated LDL (agLDL) occurs using a specialized extracellular, hydrolytic compartment, the lysosomal synapse (LS). Compartment formation by local actin polymerization and delivery of lysosomal contents by exocytosis promotes acidification of the compartment and degradation of agLDL. Intern...
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