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Frederick R. Maxfield
Cornell University
276Publications
84H-index
22.5kCitations
Publications 276
Newest
Published on Apr 1, 2019in Biochimica et Biophysica Acta3.79
Jessica Davidson (WashU: Washington University in St. Louis), Elizabeth Molitor1
Estimated H-index: 1
(WashU: Washington University in St. Louis)
+ 23 AuthorsHideji Fujiwara12
Estimated H-index: 12
(WashU: Washington University in St. Louis)
Abstract Niemann-Pick type C1 (NPC1) disease is a fatal neurovisceral disease for which there are no FDA approved treatments, though cyclodextrin (HPβCD) slows disease progression in preclinical models and in an early phase clinical trial. Our goal was to evaluate the mechanism of action of a previously described combination-therapy, Triple Combination Formulation (TCF) – comprised of the histone deacetylase inhibitor (HDACi) vorinostat/HPβCD/PEG – shown to prolong survival in Npc1 mice. In thes...
Published on Jul 25, 2019in bioRxiv
Julia Tcw4
Estimated H-index: 4
(ISMMS: Icahn School of Medicine at Mount Sinai),
Shuang A Liang (UCI: University of California, Irvine)+ 13 AuthorsElizabeth Sikora (ISMMS: Icahn School of Medicine at Mount Sinai)
Apolipoprotein E (APOE) e4 is the strongest genetic risk factor for Alzheimer9s disease (AD). Although its association with AD is well-established, the impact of APOE e4 on human brain cell function remains unclear. Here we investigated the effects of APOE e4 on several brain cell types derived from human induced pluripotent stem cells and human APOE targeted replacement mice. Gene set enrichment and pathway analyses of whole transcriptome profiles showed that APOE e4 is associated with dysregul...
Published on May 16, 2019in bioRxiv
Dana L. Cruz4
Estimated H-index: 4
(Cornell University),
Mukarram El-Banna (RU: Rutgers University)+ 4 AuthorsFrederick R. Maxfield84
Estimated H-index: 84
(Cornell University)
Alzheimers disease (AD) is characterized by the accumulation of amyloid plaques surrounded by microglia. In cell culture, microglia internalize fibrillar {beta}-amyloid but do not degrade it efficiently. Unactivated microglia have a relatively high lysosomal pH, which impairs the activity of lysosomal proteases. Previous studies showed that activation of microglia with macrophage colony stimulating factor decreases lysosomal pH and enhances fibrillar {beta}-amyloid degradation. We investigated t...
Published on Apr 30, 2019
Lynda M. Pierini18
Estimated H-index: 18
,
Frederick R. Maxfield84
Estimated H-index: 84
Published on Apr 15, 2019in bioRxiv
Rajesh K. Singh6
Estimated H-index: 6
(Cornell University),
Abigail S. Haka19
Estimated H-index: 19
(Cornell University)
+ 6 AuthorsFrederick R. Maxfield84
Estimated H-index: 84
(Cornell University)
Aggregation and modification of low-density lipoproteins (LDL) promotes their retention and accumulation in the arteries. This is a critical initiating factor during atherosclerosis. Macrophage catabolism of aggregated LDL (agLDL) occurs using a specialized extracellular, hydrolytic compartment, the lysosomal synapse (LS). Compartment formation by local actin polymerization and delivery of lysosomal contents by exocytosis promotes acidification of the compartment and degradation of agLDL. Intern...
Published on Feb 1, 2019in Arteriosclerosis, Thrombosis, and Vascular Biology6.62
Rajesh K. Singh6
Estimated H-index: 6
(Cornell University),
Abigail S. Haka19
Estimated H-index: 19
(Cornell University)
+ 2 AuthorsFrederick R. Maxfield84
Estimated H-index: 84
(Cornell University)
Objective— During atherosclerosis, LDLs (low-density lipoproteins) accumulate in the arteries, where they become modified, aggregated, and retained. Such deposits of aggregated LDL (agLDL) can be r...
Published on Nov 13, 2018in eLife7.55
Kevin C. Courtney2
Estimated H-index: 2
(U of O: University of Ottawa),
Karen Yy Fung1
Estimated H-index: 1
(St. Michael's Hospital)
+ 2 AuthorsXiaohui Zha8
Estimated H-index: 8
(Ottawa Hospital Research Institute)
Published on Oct 1, 2018in Atherosclerosis4.25
Andrew D. Nguyen8
Estimated H-index: 8
(Harvard University),
Thi A. Nguyen1
Estimated H-index: 1
(Harvard University)
+ 9 AuthorsEric J. Huang52
Estimated H-index: 52
(UCSF: University of California, San Francisco)
Abstract Background and aims Progranulin is a circulating protein that modulates inflammation and is found in atherosclerotic lesions. Here we determined whether inflammatory cell–derived progranulin impacts atherosclerosis development. Methods Ldlr –/– mice were transplanted with bone marrow from wild-type (WT) or Grn –/– (progranulin KO) mice (referred to as Tx-WT and Tx-KO, respectively). Results After 10 weeks of high-fat diet feeding, both groups displayed similarly elevated plasma levels o...
Santiago Solé-Domènech3
Estimated H-index: 3
(Cornell University),
Ana V. Rojas4
Estimated H-index: 4
(Cornell University)
+ 3 AuthorsFrederick R. Maxfield84
Estimated H-index: 84
(Cornell University)
Accumulation of amyloid-beta (Aβ), which is associated with Alzheimer’s disease, can be caused by excess production or insufficient clearance. Because of its β-sheet structure, fibrillar Aβ is resistant to proteolysis, which would contribute to slow degradation of Aβ plaques in vivo. Fibrillar Aβ can be internalized by microglia, which are the scavenger cells of the brain, but the fibrils are degraded only slowly in microglial lysosomes. Cathepsin B is a lysosomal protease that has been shown to...
Published on Dec 1, 2017in BMC Biology6.72
Christopher J. Stefan24
Estimated H-index: 24
(UCL: University College London),
William S. Trimble54
Estimated H-index: 54
(U of T: University of Toronto)
+ 17 AuthorsTimothy P. Levine34
Estimated H-index: 34
(UCL Institute of Ophthalmology)
Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and organelle biogenesis continue to be a puzzle. This is because lipids flow from many sources and across many paths via transport vesicles, non-vesicular transfer proteins, and dynamic interactions between organelles at membrane contact sites. This forum presents ...
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