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Ting Chen
Soochow University (Suzhou)
EndocrinologyInsulinDiabetic ketoacidosisDiabetes mellitusMedicine
16Publications
2H-index
13Citations
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Publications 16
Newest
#1Xiaoyan Wang (Soochow University (Suzhou))
#2Fengyun Wang (Soochow University (Suzhou))H-Index: 2
Last. Linqi Chen (Soochow University (Suzhou))H-Index: 2
view all 9 authors...
The aim of the present study was to explore the genetic causes of antibody-negative diabetes and investigate its characteristics. A total of 64 patients with new-onset diabetes (>6 m, /=0.3 ng/ml. Peripheral blood DNA was extracted from the subjects and their parents for high-throughput sequencing of glucose metabolism-related genes. The group with the pathogenic variation was used as the experimental group. The control group comprised 32 cases of type 1 diabetes (T1D). Their baseline clinical c...
Source
#1Shuiyan Wu (Soochow University (Suzhou))
#2Ying Liu (Soochow University (Suzhou))
Last. Zhenjiang Bai (Soochow University (Suzhou))H-Index: 4
view all 10 authors...
BACKGROUND: Cockayne syndrome (CS) is a rare autosomal recessive disorder which displays multiorgan dysfunction, especially within the nervous system including psychomotor retardation, cerebral atrophy, microcephaly, cognitive dysfunction, mental retardation, and seizures. Many genetic variations reported were related to this syndrome, but splicing mutations with cardiac anomalies have not been found in previous studies. METHODS: Herein, we described a pair of brothers and sisters who present es...
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#1Ting Chen (Soochow University (Suzhou))H-Index: 2
#2Linqi Chen (Soochow University (Suzhou))H-Index: 2
Last. Fei Xiao (Soochow University (Suzhou))H-Index: 1
view all 8 authors...
Background. Central precocious puberty (CPP) is defined by gonadotropin-dependent development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. MKRN3 and DLK1 are two genes, disease-causing variants of which have recently been discovered to cause idiopathic CPP. Methods. We screened 173 Chinese patients (9 males and 164 females; 9 familial and 164 sporadic) with ICPP and 43 patients (9 males and 34 females; 3 familial and 40 sporadic) with early puberty ...
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#1Ting Chen (Soochow University (Suzhou))H-Index: 2
#2Fengyun Wang (Soochow University (Suzhou))H-Index: 2
Last. Miao Hou (Soochow University (Suzhou))H-Index: 2
view all 10 authors...
Purpose CTRP3 is a novel peptide that has recently emerged as an important regulatory adipokine of obesity and related metabolic disease. Little is known about its role in children. The current study aimed to investigate the potential role of CTRP3 in obese children and explore its relationships with insulin sensitivity, pancreatic β cell function, and obesity-related markers.
Source
#1Dandan Zhang (Soochow University (Suzhou))
#2Linqi Chen (Soochow University (Suzhou))H-Index: 2
Last. Xiaoyan Wang (Soochow University (Suzhou))
view all 10 authors...
对2017年苏州大学附属儿童医院内分泌遗传代谢科和重症医学科收治的2例糖尿病酮症酸中毒危重患儿的临床表现、实验室检查及抢救治疗过程进行回顾性分析。例1,女,13岁5个月,诊断"1型糖尿病、酮症酸中毒、急性肾损伤(3期)";例2,女,2个月8 d,诊断"新生儿糖尿病、酮症酸中毒、高渗高血糖综合征",予常规补液、胰岛素降糖治疗效果不佳,行连续性血液透析滤过治疗后缓解;为明确病因,行基因检测,例2检出KCNJ11基因存在c.602G>A(p.R201H)杂合突变。提示对于儿童糖尿病酮症酸中毒危重患者,在常规补液、胰岛素降糖治疗效果不佳,合并其他器官功能损伤及顽固性酸中毒时,积极行连续性血液透析滤过治疗,可获得显著效果。
Source
#1Xiaoyan Wang (Soochow University (Suzhou))
#1Xiaoqin Wang (Soochow University (Suzhou))H-Index: 11
Last. Linqi Chen (Soochow University (Suzhou))H-Index: 2
view all 10 authors...
1例主诉为"体重不增2个月余,发现血钙过高半个月"的患儿就诊于苏州大学附属儿童医院内分泌遗传代谢科,患儿血浆游离钙1.57 mmol/L,总钙3.3 mmol/L,磷0.99 mmol/L,B超提示双肾钙盐沉积,全外显子基因测序发现,患儿存在SLC34A1基因c.581G>A(p.G194D)和c.627delC(p.D209Efs*77)复合杂合变异,诊断为特发性婴儿高钙血症。国内尚无SLC34A1基因变异患者报道。.
Source
#1Ting ChenH-Index: 2
#2Fengyun WangH-Index: 2
Last. Miao HouH-Index: 2
view all 9 authors...
OBJECTIVES: Spexin (SPX) is a novel peptide that has recently emerged as an important regulatory adipokine of obesity and related metabolic disease. Little is known about its role in children. The aim of the current study was to determine the potential role of SPX in obese children and explore its relationships with obesity-related markers, insulin sensitivity and pancreatic β cell function. METHOD: We studied the levels of serum SPX in 40 obese and 32 normal weight pre-puberty children (mean ag...
2 CitationsSource
#1Ting Chen (Soochow University (Suzhou))H-Index: 2
#2Haiying Wu (Soochow University (Suzhou))H-Index: 2
Last. Fei Xiao (Soochow University (Suzhou))H-Index: 1
view all 11 authors...
Background. Bone mineral density quantitative trait locus 18 (BMND18, OMIM #300910) is a type of early-onset osteogenesis imperfecta (OI) caused by loss-of-function mutations in the PLS3 gene, which encodes plastin-3, a key protein in the formation of actin bundles throughout the cytoskeleton. Here, we report a patient with PLS3 mutation caused BMND18 and evaluated all the reported disease-causing mutations by bioinformatic analysis. Methods. Targeted gene sequencing was performed to find the di...
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#1Ting Chen (Soochow University (Suzhou))H-Index: 2
#2Dandan Zhang (Soochow University (Suzhou))
Last. Linqi Chen (Soochow University (Suzhou))H-Index: 2
view all 12 authors...
Neonatal diabetes mellitus (NDM) is a rare monogenic disorder presenting as uncontrolled hyperglycemia during the first 6 months of life. Hyperglycemic hyperosmolar state (HHS) is quite rare in NDM patients, and reported experience with this condition is limited. Continuous renal replacement therapy (CRRT) is frequently used as a mode of dialytic treatment in critically ill patients with acute renal failure, but has seldom been used in patients with diabetic ketoacidosis (DKA) and HHS. We report...
Source
#1Shuiyan Wu (Soochow University (Suzhou))
#2Ting Chen (Soochow University (Suzhou))H-Index: 2
Last. Zhenjiang Bai (Soochow University (Suzhou))H-Index: 4
view all 7 authors...
Abstract Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a rare autosomal recessive disease characterized by infancy-onset diaphragmatic palsy and symmetrical distal muscular weakness. SMARD1 is caused by loss-of-function mutations in IGHMBP2 gene. In this article, we report a male SMARD1 patient with two compound heterozygous mutations (NM_002180.2: c.688C > G; p.(Gln230Glu)) and (NM_002180.2: c.1737C > A; p.(Phe579Leu)), one of which (c.688C > G; ClinVar accession: SUB3344...
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