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Tingxi Guo
Princess Margaret Cancer Centre
Molecular biologyT-cell receptorImmunologyT cellBiology
21Publications
7H-index
237Citations
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Publications 21
Newest
#1Yuki KagoyaH-Index: 12
#2Tingxi Guo (Princess Margaret Cancer Centre)H-Index: 7
Last. Yukiko Matsunaga (Princess Margaret Cancer Centre)H-Index: 1
view all 13 authors...
Adoptive immunotherapy can induce sustained therapeutic effects in some cancers. Antitumor T cell grafts are often individually prepared in vitro from autologous T cells, which requires an intensive workload and increased costs. The quality of the generated T cells can also be variable, which affects the therapy's antitumor efficacy and toxicity. Standardized production of antitumor T cell grafts from third-party donors will enable widespread use of this modality if allogeneic T cell responses a...
Source
#1Kenji Murata (Princess Margaret Cancer Centre)H-Index: 1
#2Munehide Nakatsugawa (Princess Margaret Cancer Centre)H-Index: 13
Last. Yuki Kagoya (Princess Margaret Cancer Centre)H-Index: 12
view all 25 authors...
HLA-restricted T cell responses can induce antitumor effects in cancer patients. Previous human T cell research has largely focused on the few HLA alleles prevalent in a subset of ethnic groups. Here, using a panel of newly developed peptide-exchangeable peptide/HLA multimers and artificial antigen-presenting cells for 25 different class I alleles and greater than 800 peptides, we systematically and comprehensively mapped shared antigenic epitopes recognized by tumor-infiltrating T lymphocytes (...
Source
#1Kenji Murata (Princess Margaret Cancer Centre)H-Index: 1
#2Munehide Nakatsugawa (Princess Margaret Cancer Centre)H-Index: 13
Last. Yuki Kagoya (Princess Margaret Cancer Centre)H-Index: 12
view all 25 authors...
Source
#1Mark Anczurowski (U of T: University of Toronto)H-Index: 6
#2Kenji Sugata (Princess Margaret Cancer Centre)H-Index: 1
Last. Naoto Hirano (U of T: University of Toronto)H-Index: 11
view all 12 authors...
Abstract Recent work has delineated key differences in the antigen processing and presentation mechanisms underlying HLA-DP alleles encoding glycine at position 84 of the DPβ chain (DP 84GGPM87 ). These DPs are unable to associate with the class II-associated Ii peptide (CLIP) region of the invariant chain (Ii) chaperone early in the endocytic pathway, leading to continuous presentation of endogenous antigens. However, little is known about the chaperone support involved in the loading of these ...
Source
#1Yuki Kagoya (Princess Margaret Cancer Centre)H-Index: 12
#2Hiroshi Saijo (Princess Margaret Cancer Centre)H-Index: 1
Last. Naoto Hirano (U of T: University of Toronto)H-Index: 11
view all 12 authors...
Abstract Forkhead box transcription factor 3 (FOXP3) plays a pivotal role in the suppressive function of regulatory T cells. In addition to mRNA levels, FOXP3 activity can also be controlled by posttranslational mechanisms, which have not been studied in a comprehensive manner. Through extensive screening using selective inhibitors, we demonstrate that the inhibition of type I protein arginine methytransferases (PRMTs) attenuates the suppressive functions of regulatory T cells. FOXP3 undergoes m...
6 CitationsSource
#1Yuki Kagoya (Princess Margaret Cancer Centre)H-Index: 12
#2Munehide Nakatsugawa (Princess Margaret Cancer Centre)H-Index: 13
Last. Naoto Hirano (U of T: University of Toronto)H-Index: 11
view all 9 authors...
Adoptive T-cell therapy is a promising therapeutic approach for cancer patients. The use of allogeneic T-cell grafts will improve its applicability and versatility provided that inherent allogeneic responses are controlled. T-cell activation is finely regulated by multiple signaling molecules that are transcriptionally controlled by epigenetic mechanisms. Here we report that inhibiting DOT1L, a histone H3-lysine 79 methyltransferase, alleviates allogeneic T-cell responses. DOT1L inhibition reduc...
3 CitationsSource
#1Mark Anczurowski (U of T: University of Toronto)H-Index: 6
#2Yuki Yamashita (Princess Margaret Cancer Centre)H-Index: 6
Last. Naoto Hirano (U of T: University of Toronto)H-Index: 11
view all 11 authors...
While the principles of classical antigen presentation via MHC class II are well-established, the mechanisms for the many routes of cross-presentation by which endogenous antigens become associated with class II molecules are not fully understood. We have recently demonstrated that the single amino acid polymorphism HLA-DPβ84Gly (DP84Gly) is critical to abrogate class II invariant chain associated peptide (CLIP) region-mediated binding of invariant chain (Ii) to DP, allowing endoplasmic reticulu...
3 CitationsSource
#1Yuki KagoyaH-Index: 12
#2Shinya TanakaH-Index: 4
Last. Naoto HiranoH-Index: 11
view all 9 authors...
Optimal T cell activation requires signaling through the T cell receptor (signal 1), a co-stimulatory receptor (signal 2) and a cytokine receptor (signal 3), yet most chimeric antigen receptors (CARs) lack a domain to transduce signal 3. Kagoya et al. now report their development of a new CAR that incorporates a JAK–STAT cytokine signaling domain and mediates potent antitumor effects.
41 CitationsSource
#1Tingxi Guo (U of T: University of Toronto)H-Index: 7
#2Ming Yin Koo (U of T: University of Toronto)H-Index: 1
Last. Naoto Hirano (U of T: University of Toronto)H-Index: 11
view all 8 authors...
In humans, a substantial portion of T cells recognize lipids presented by the monomorphic CD1 proteins. Recent studies have revealed the molecular basis of mycobacterial lipid recognition by CD1c-restricted T cells. Subsets of CD1c-restricted T cells recognize self-lipids in addition to foreign lipids, which may have implications in human diseases involving autoimmunity and malignancy. However, the molecular identity of these self-reactive T cells remains largely elusive. In this study, using a ...
3 CitationsSource
#1Yuki Yamashita (Princess Margaret Cancer Centre)H-Index: 6
#2Mark Anczurowski (U of T: University of Toronto)H-Index: 6
Last. Naoto Hirano (U of T: University of Toronto)H-Index: 11
view all 14 authors...
MHC class I and II molecules generally present endogenous and exogenous peptides, respectively, through distinct mechanisms. Here, the authors show that the class II molecule HLA-DP84Gly uses both class I and II mechanisms to constitutively present peptides.
10 CitationsSource
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