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Claire Fonti
University of Montpellier
4Publications
1H-index
72Citations
Publications 4
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#1Claire Fonti (University of Montpellier)H-Index: 1
#2Anne Saumet (University of Montpellier)H-Index: 11
Last.Charles Theillet (University of Montpellier)H-Index: 56
view all 14 authors...
1 CitationsSource
#1Stan P. du manoir (University of Montpellier)
#2Claire Fonti (University of Montpellier)H-Index: 1
Last.Charles Theillet (University of Montpellier)H-Index: 56
view all 11 authors...
Gene expression differences, combined with distinct patterns of genomic rearrangements and epigenetic modifications constitute the bases of molecular classification of breast cancer. Molecular subtypes may originate from different cell lineages in the mammary gland, but also from the early activation of oncogenes that may drive the establishment of these molecular subtypes. However, in the natural history of human cancer, it is difficult to discriminate between these two factors : cell lineage a...
Source
#1Claire Fonti (University of Montpellier)H-Index: 1
#2Anne Saumet (French Institute of Health and Medical Research)H-Index: 11
Last.Charles Theillet (French Institute of Health and Medical Research)H-Index: 56
view all 14 authors...
Gene expression differences, combined with distinct patterns of genomic rearrangements and epigenetic modifications, have laid the bases of molecular classification of breast cancer. Different molecular subtypes are thought to originate from different cell lineages in the mammary gland, but the early activation of an oncogene could also play a role. It is, however, difficult to discriminate the respective inputs of oncogene activation or cell type of origin in the natural history of the tumor. I...
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#1Romuald BinetH-Index: 4
#2Damien YthierH-Index: 7
Last.Rémy Pedeux (University of Rennes)H-Index: 20
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Senescence is a tumor suppression mechanism that is induced by several stimuli, including oncogenic signaling and telomere shortening, and controlled by the p53/p21 WAF1 signaling pathway. Recently, a critical role for secreted factors has emerged, suggesting that extracellular signals are necessary for the onset and maintenance of senescence. Conversely, factors secreted by senescent cells may promote tumor growth. By using expression profiling techniques, we searched for secreted factors that ...
71 CitationsSource
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