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Filippo Martini
University of Bologna
3Publications
1H-index
8Citations
Publications 3
Newest
#1Neil HoaH-Index: 16
#2Lisheng GeH-Index: 9
Last.Martin R. Jadus (University of California, Berkeley)H-Index: 24
view all 7 authors...
ABSTRACTObjective: Temozolomide (TMZ) improves Glioblastoma Multiforme (GBM) patient survival. The invasive behavior of the glioma cells is the cause of GBM relapse. The glioma BK ion channel (gBK) may provide glioma cells with a mechanism to invade surrounding tissue. gBK contains epitopes that cytolytic T lymphocytes (CTLs) can recognize and kill glioma cells. Fascin-1 is an actin crosslinking molecule that supports microvilli; these membrane protrusions provide a physical defense against CTLs...
1 CitationsSource
#1Neil HoaH-Index: 16
#2Lisheng GeH-Index: 9
Last.Martin R. JadusH-Index: 24
view all 9 authors...
Cancer cells derived from Glioblastoma multiforme possess membranous protrusions allowing these cells to infiltrate surrounding tissue, while resisting lymphocyte cytotoxicity. Microvilli and filopodia are supported by actin filaments cross-linked by fascin. Fascin-1 was genetically silenced within human U251 glioma cells; these knock-down glioma cells lost their microvilli/filopodia. The doubling time of these fascin-1 knock-down cells was doubled that of shRNA control U251 cells. Fascin-1 knoc...
7 Citations
#1Neil HoaH-Index: 16
#2Lisheng GeH-Index: 9
view all 9 authors...
Cancer cells derived from Glioblastoma multiforme possess membranous protrusions allowing these cells to infiltrate surrounding tissue, while resisting lymphocyte cytotoxicity. Microvilli and filopodia are supported by actin filaments cross-linked by fascin. Fascin-1 was genetically silenced within human U251 glioma cells; these knock- down glioma cells lost their microvilli/filopodia. The doubling time of these fascin-1 knock-down cells was doubled that of shRNA control U251 cells. Fascin-1 kno...
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