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Yongjun Xiao
McGill University
24Publications
14H-index
810Citations
Publications 24
Newest
BACKGROUND Patients with HIV exposed to the antiretroviral drug abacavir may have an increased risk of cardiovascular disease (CVD). There is concern that this association arises because of a channelling bias. Even if exposure is a risk, it is not clear how that risk changes as exposure cumulates. METHODS We assess the effect of exposure to abacavir on the risk of CVD events in the Swiss HIV Cohort Study. We use a new marginal structural Cox model to estimate the effect of abacavir as a flexible...
45 CitationsSource
#1Yongjun XiaoH-Index: 14
#2Michal Abrahamowicz (McGill University)H-Index: 71
Last.James B. YoungH-Index: 117
view all 5 authors...
The association between antiretroviral treatment and cardiovascular disease (CVD) risk in HIV-positive persons has been the subject of much debate since the Data collection on Adverse events of Anti-HIV Drugs (D:A:D) study reported that recent use of two antiretroviral drugs, abacavir (ABC) and didanosine (DDI), was associated with increased risk. We focus on the potential impact of DDI use, as this drug has not been as studied intensively as ABC. We propose a flexible marginal structural Cox mo...
23 CitationsSource
#1Yongjun Xiao (McGill University)H-Index: 14
#2Erica E. M. Moodie (McGill University)H-Index: 23
Last.Michal Abrahamowicz (McGill University)H-Index: 71
view all 3 authors...
Marginal structural Cox Models (Cox MSMs) have been used to estimate the causal effect of a time-varying treatment on the hazard when there exist time-dependent confounders, which are themselves also affected by previous treatment. A Cox MSM can be estimated via the inverse-probability-of-treatment weighting (IPTW) estimator. However, IPTW estimators suffer from large variability if some observations are assigned extremely high weights. Weight truncation has been proposed as one simple solution ...
33 CitationsSource
#1Yongjun XiaoH-Index: 14
#2Gareth D. JonesH-Index: 12
Last.Sean A. GuidryH-Index: 5
view all 7 authors...
3 Citations
#1Huisong ZhengH-Index: 25
#2Jonathan H TobiasH-Index: 39
Last.Mattias LorentzonH-Index: 55
view all 55 authors...
We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts comprising 5,672 individuals. We then assessed selected single-nucleotide polymorphisms (SNPs) for osteoporotic fracture in 2,023 cases and 3,740 controls. Association with CBT and forearm BMD was tested for ∼2.5 million SNPs ...
1 Citations
#1Huisong Zheng (McGill University)H-Index: 25
#2Jonathan H Tobias (UoB: University of Bristol)H-Index: 39
Last.Mattias Lorentzon (University of Gothenburg)H-Index: 55
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We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts comprising 5,672 individuals. We then assessed selected single-nucleotide polymorphisms (SNPs) for osteoporotic fracture in 2,023 cases and 3,740 controls. Association with CBT and forearm BMD was tested for ,2.5 million SNPs ...
150 CitationsSource
#1Huisong Zheng (McGill University)H-Index: 25
#2Emma L. Duncan (UQ: University of Queensland)H-Index: 37
Last.J. B. Richards (McGill University)
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The 7Q31 locus, containing WNT16, is associated with bone mineral density, osteoporotic fracture and bone strength
Source
#1Yingben Xue (McGill University)H-Index: 4
#2Yongjun Xiao (McGill University)H-Index: 14
Last.David Goltzman (McGill University)H-Index: 79
view all 8 authors...
Although the calcium-sensing receptor (CaSR) and parathyroid hormone (PTH) may each exert skeletal effects, it is uncertain how CaSR and PTH interact at the level of bone in primary hyperparathyroidism (PHPT). Therefore, we simulated PHPT with 2 wk of continuous PTH infusion in adult mice with deletion of the PTH gene (Pth−/− mice) and with deletion of both PTH and CaSR genes (Pth−/−-Casr −/− mice) and compared skeletal phenotypes. PTH infusion in Pth−/− mice increased cortical bone turnover, au...
25 CitationsSource
#1Huisong ZhengH-Index: 25
#2Emma L. DuncanH-Index: 37
Last.J. Brent RichardsH-Index: 45
view all 32 authors...
WNT16 is associated with bone mineral density, osteoporotic fracture and bone strength : a large-scale meta-analysis of genomewide association studies
Source
#1Eric B. Loucks (McGill University)H-Index: 28
#2Michal Abrahamowicz (McGill University)H-Index: 71
Last.John Lynch (UoB: University of Bristol)H-Index: 81
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Background Education is inversely associated with cardiovascular disease incidence in developed countries. Blood pressure may be an explanatory biological mechanism. However few studies have investigated educational gradients in longitudinal blood pressure trajectories, particularly over substantial proportions of the life course. Study objectives were to determine whether low education was associated with increased blood pressure from multiple longitudinal assessments over 30 years. Furthermore...
38 CitationsSource
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