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Y. Xiao
McGill University
22Publications
13H-index
693Citations
Publications 22
Newest
Published on Aug 1, 2015in Journal of Acquired Immune Deficiency Syndromes 4.12
James B. Young118
Estimated H-index: 118
,
Y. Xiao13
Estimated H-index: 13
+ 9 AuthorsAlexia Cusini14
Estimated H-index: 14
BACKGROUND Patients with HIV exposed to the antiretroviral drug abacavir may have an increased risk of cardiovascular disease (CVD). There is concern that this association arises because of a channelling bias. Even if exposure is a risk, it is not clear how that risk changes as exposure cumulates. METHODS We assess the effect of exposure to abacavir on the risk of CVD events in the Swiss HIV Cohort Study. We use a new marginal structural Cox model to estimate the effect of abacavir as a flexible...
43 Citations Source Cite
Published on Apr 3, 2014in Journal of the American Statistical Association 2.30
Y. Xiao13
Estimated H-index: 13
,
Michal Abrahamowicz68
Estimated H-index: 68
(McGill University)
+ 2 AuthorsJames B. Young118
Estimated H-index: 118
The association between antiretroviral treatment and cardiovascular disease (CVD) risk in HIV-positive persons has been the subject of much debate since the Data collection on Adverse events of Anti-HIV Drugs (D:A:D) study reported that recent use of two antiretroviral drugs, abacavir (ABC) and didanosine (DDI), was associated with increased risk. We focus on the potential impact of DDI use, as this drug has not been as studied intensively as ABC. We propose a flexible marginal structural Cox mo...
21 Citations Source Cite
Published on Jan 8, 2013
Y. Xiao13
Estimated H-index: 13
(McGill University),
Erica E. M. Moodie21
Estimated H-index: 21
(McGill University),
Michal Abrahamowicz68
Estimated H-index: 68
(McGill University)
Marginal structural Cox Models (Cox MSMs) have been used to estimate the causal effect of a time-varying treatment on the hazard when there exist time-dependent confounders, which are themselves also affected by previous treatment. A Cox MSM can be estimated via the inverse-probability-of-treatment weighting (IPTW) estimator. However, IPTW estimators suffer from large variability if some observations are assigned extremely high weights. Weight truncation has been proposed as one simple solution ...
25 Citations Source Cite
Published on Jul 5, 2012in PLOS Genetics 5.54
Huisong Zheng23
Estimated H-index: 23
(McGill University),
Jonathan H Tobias38
Estimated H-index: 38
(UoB: University of Bristol)
+ 52 AuthorsMika Kähönen74
Estimated H-index: 74
(UTA: University of Tampere)
We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts comprising 5,672 individuals. We then assessed selected single-nucleotide polymorphisms (SNPs) for osteoporotic fracture in 2,023 cases and 3,740 controls. Association with CBT and forearm BMD was tested for ,2.5 million SNPs ...
136 Citations Source Cite
Published on May 1, 2012in Bone 4.46
Huisong Zheng23
Estimated H-index: 23
(McGill University),
Emma L. Duncan36
Estimated H-index: 36
(UQ: University of Queensland)
+ 29 AuthorsRichard Prince58
Estimated H-index: 58
(UWA: University of Western Australia)
The 7Q31 locus, containing WNT16, is associated with bone mineral density, osteoporotic fracture and bone strength
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Published on Jan 1, 2012in Osteoporosis International 3.86
Huisong Zheng23
Estimated H-index: 23
,
Emma L. Duncan36
Estimated H-index: 36
+ 29 AuthorsRichard Prince58
Estimated H-index: 58
WNT16 is associated with bone mineral density, osteoporotic fracture and bone strength : a large-scale meta-analysis of genomewide association studies
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Published on Dec 1, 2011in BMC Public Health 2.42
Eric B. Loucks27
Estimated H-index: 27
(McGill University),
Michal Abrahamowicz68
Estimated H-index: 68
(McGill University)
+ 1 AuthorsJohn Lynch79
Estimated H-index: 79
(UoB: University of Bristol)
Background Education is inversely associated with cardiovascular disease incidence in developed countries. Blood pressure may be an explanatory biological mechanism. However few studies have investigated educational gradients in longitudinal blood pressure trajectories, particularly over substantial proportions of the life course. Study objectives were to determine whether low education was associated with increased blood pressure from multiple longitudinal assessments over 30 years. Furthermore...
36 Citations Source Cite
Published on Mar 8, 2010in Statistics in Medicine 1.93
Y. Xiao13
Estimated H-index: 13
(McGill University),
Michal Abrahamowicz68
Estimated H-index: 68
(McGill University)
We propose two bootstrap-based methods to correct the standard errors (SEs) from Cox's model for within-cluster correlation of right-censored event times. The cluster-bootstrap method resamples, with replacement, only the clusters, whereas the two-step bootstrap method resamples (i) the clusters, and (ii) individuals within each selected cluster, with replacement. In simulations, we evaluate both methods and compare them with the existing robust variance estimator and the shared gamma frailty mo...
7 Citations Source Cite
Published on Jan 8, 2010in The International Journal of Biostatistics 0.84
Y. Xiao13
Estimated H-index: 13
(McGill University),
Michal Abrahamowicz68
Estimated H-index: 68
(MGH: Montreal General Hospital),
Erica E. M. Moodie21
Estimated H-index: 21
(McGill University)
Marginal structural models (MSM) provide a powerful tool to control for confounding by a time-dependent covariate without inappropriately adjusting for its role as a variable affected by treatment (Hernan et al., 2000). In this paper, we demonstrate that it is possible to fit a marginal structural Cox model directly, rather than the typical approach of using pooled logistic regression, using the weighted Cox proportional hazards function that has been implemented in standard software. To evaluat...
44 Citations Source Cite
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