Andrew Carr
University of Oxford
SurgeryPhysical therapyImmunologyRotator cuffMedicine
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Publications 986
#1David J. Keene (University of Oxford)H-Index: 7
#2Hessam Soutakbar (University of Oxford)H-Index: 1
Last. Sarah E Lamb (University of Oxford)H-Index: 49
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ABSTRACT Objectives The Getting it Right: Addressing Shoulder Pain (GRASP) trial is a large-scale, multicentre, 2 × 2 factorial randomised controlled trial investigating clinical and cost-effectiveness of a progressive exercise programme versus best-practice advice, with or without corticosteroid injection, for treating people with rotator cuff disorders. Here we describe the development, implementation and details of the physiotherapy-led interventions. Methods Medical Research Council guidance...
#1Sunny Vijen (Oxford Brookes University)
#2Chris Hawes (Oxford Brookes University)H-Index: 59
Last. Yun Zhang (Oxford Brookes University)
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ANKH mutations are associated with calcium pyrophosphate deposition disease and craniometaphyseal dysplasia. This study investigated the effects of these ANKH mutants on cellular localisation and associated biochemistry. We generated four ANKH overexpression-plasmids containing either calcium pyrophosphate deposition disease or craniometaphyseal dysplasia linked mutations: P5L, E490del and S375del, G389R. They were transfected into CH-8 articular chondrocytes and HEK293 cells. The ANKH mutants d...
#1I. Mary Poynten (UNSW: University of New South Wales)H-Index: 9
#2Fengyi Jin (UNSW: University of New South Wales)H-Index: 34
Last. Annabelle FarnsworthH-Index: 4
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BACKGROUND: Gay and bisexual men (GBM) are disproportionately affected by anal cancer. Prevention is hindered by incomplete understanding of the natural history of its precursor, anal high-grade squamous intraepithelial lesions (HSIL). METHODS: The Study of the Prevention of Anal Cancer, conducted between 2010 and 2018, enrolled human immunodeficiency virus (HIV)-positive and HIV-negative GBM aged >/=35 years. Anal cytology and high-resolution anoscopy (HRA) were performed at baseline and 3 annu...
#1Mathew J. BaldwinH-Index: 4
#2Navraj S NagraH-Index: 4
Last. Jonathan CookH-Index: 42
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Background Rotator cuff tears are a common cause of shoulder pain and can result in prolonged periods of pain, disability and absence from work. Rotator cuff repair surgery is increasingly used in an attempt to resolve symptoms but has failure rates of around 40%. There is a pressing need to improve the outcome of rotator cuff repairs. Patch augmentation increasingly being used within the NHS in an attempt to reduce repair failures. The aim of this survey was to determine current UK practice and...
#1David J Beard (University of Oxford)H-Index: 49
#2Loretta Davies (University of Oxford)H-Index: 3
Last. Helen Campbell (University of Oxford)H-Index: 16
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BACKGROUND: Late-stage medial compartment knee osteoarthritis can be treated using total knee replacement or partial (unicompartmental) knee replacement. There is high variation in treatment choice and insufficient evidence to guide selection. OBJECTIVE: To assess the clinical effectiveness and cost-effectiveness of partial knee replacement compared with total knee replacement in patients with medial compartment knee osteoarthritis. The findings are intended to guide surgical decision-making for...
#1Sian Cousins (UoB: University of Bristol)H-Index: 10
#2Natalie S Blencowe (UoB: University of Bristol)H-Index: 15
Last. Jane M Blazeby (UoB: University of Bristol)H-Index: 58
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BACKGROUND: Placebo-controlled trials play an important role in the evaluation of healthcare interventions. However, they can be challenging to design and deliver for invasive interventions, including surgery. In-depth understanding of the component parts of the treatment intervention is needed to ascertain what should, and should not, be delivered as part of the placebo. Assessment of risk to patients and strategies to ensure that the placebo effectively mimics the treatment are also required. ...
#1Mustafa S. Rashid (University of Oxford)H-Index: 2
#2Jayesh Dudhia (RVC: Royal Veterinary College)H-Index: 30
Last. Andrew Carr (University of Oxford)H-Index: 93
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We investigated endogenous tissue response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch intended for tendon repair. A sheep tendon injury model characterised by a natural history of consistent failure of healing was chosen to assess the biological potential of woven and aligned electrospun fibres to induce a reparative response. Patches were implanted into 8 female adult English Mule sheep. Significant infiltration of tendon fibroblasts was observed within the ...
#1David J Beard (University of Oxford)H-Index: 49
#2Marion K Campbell (Aberd.: University of Aberdeen)H-Index: 43
Last. Jonathan Pugh (University of Oxford)H-Index: 6
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Summary Placebo comparisons are increasingly being considered for randomised trials assessing the efficacy of surgical interventions. The aim of this Review is to provide a summary of knowledge on placebo controls in surgical trials. A placebo control is a complex type of comparison group in the surgical setting and, although powerful, presents many challenges. This Review outlines what a placebo control entails and present understanding of this tool in the context of surgery. We consider when p...