James R. Bebb
University of Nottingham
Publications 18
#1Philip OppongH-Index: 1
#2Debabrata MajumdarH-Index: 2
Last.James R. BebbH-Index: 7
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Nearly all peptic ulcers are caused either by Helicobacter pylori infection or by use of non-steroidal anti-inflammatory drugs (NSAIDs), which include aspirin. As H. pylori infection is becoming less prevalent in developed countries, NSAIDs are an increasingly important cause of ulceration, including ulcers complicated by bleeding. Only about 15% of H. pylori-infected people develop an ulcer in their lifetime; virulence of the H. pylori strain, host genetics and environment (particularly smoking...
25 CitationsSource
#1James R. BebbH-Index: 7
#2Lopa LeachH-Index: 27
Last.John AthertonH-Index: 64
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Background: The cadherin–catenin complex is the key component of the adherens junction in epithelial cells, and changes in this complex are implicated in gastric adenocarcinoma. Germline mutations in E-cadherin have been described in diffuse-type gastric adenocarcinoma. Helicobacter pylori infection is the first stage in gastric carcinogenesis. Aims: To determine whether H pylori was associated with changes in the complex, and whether this was affected by virulence of the strain. Methods: Epithe...
28 CitationsSource
#1Clare T. Atherton (University of Nottingham)H-Index: 5
#2John Jones (University of Nottingham)H-Index: 4
Last.Christopher J. Hawkey (University of Nottingham)H-Index: 79
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Abstract Background & Aims: Lumiracoxib is a structurally novel, acidic selective inhibitor of cyclooxygenase (COX)-2. We coordinated existing methodologies in a single study to evaluate potency, selectivity, and effect on the human gastrointestinal tract. Methods: Twenty four healthy subjects (aged 18–45 years, 12 female) received high dose lumiracoxib (800 mg every day), standard dose naproxen (500 mg twice a day), or placebo for 8 days in a double-blind randomized crossover study. At the star...
38 CitationsSource
#2John JonesH-Index: 4
Last.I T BjarnasonH-Index: 1
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Background: Cyclooxygenase inhibiting nitric oxide donators (CINODs) are a new class of anti-inflammatory and analgesic drugs that may minimise gastrointestinal toxicity compared with standard non-steroidal anti-inflammatory drugs (NSAIDs) by virtue of nitric oxide donation. Methods: A proof of concept study of the gastrointestinal safety of AZD3582, the first CINOD available for human testing, was conducted. Thirty one subjects were randomised to receive placebo, naproxen 500 mg twice daily, or...
90 CitationsSource
#1James R. BebbH-Index: 7
#2Darren P. LetleyH-Index: 19
Last.John AthertonH-Index: 64
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Background and aims: Matrix metalloproteinase-7 (MMP-7) is important in normal and pathological remodelling of epithelial-matrix interactions, and is upregulated in gastric cancer. Helicobacter pylori infection is the first stage in gastric carcinogenesis, and therefore our aim was to determine if H pylori upregulated gastric MMP-7 expression and if this was affected by strain virulence. Methods: We took gastric biopsy specimens at endoscopy from H pylori infected (n = 17) and uninfected (n = 18...
68 CitationsSource
Objective: To determine whether mastic gum suppresses or eradicates Helicobacter pylori infection in humans. Patients and methods: Nine patients with H. pylori infection, and without gastroduodenal ulceration, were recruited from day-case endoscopy lists and treated with mastic 1 g four times daily for 14 days. ( 13 C)Urea breath tests (UBTs) were carried out immediately before, on day 15 and 5 weeks after treatment with mastic. Results: Mastic had no effect on H. pylori status in any of the eig...
36 CitationsSource
#1James R. Bebb (University of Nottingham)H-Index: 7
#2Darren P. Letley (University of Nottingham)H-Index: 19
Last.John Atherton (University of Nottingham)H-Index: 64
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We show here that Helicobacter pylori broth culture supernatants disrupt the actin cytoskeleton of epithelial cell lines, leading to cell rounding and apoptosis through anoikis. We demonstrate that there are marked quantitative differences between strains and that there are different cell line sensitivities. By constructing VacA null isogenic mutants, we show that the effect is not due to the vacuolating cytotoxin.
18 CitationsSource
#1Julie A. SmithH-Index: 9
Last.Christopher J. HawkeyH-Index: 79
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#1James R. BebbH-Index: 7
#2Francisco AvilesH-Index: 1
Last.John AthertonH-Index: 64
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#2Darren P. LetleyH-Index: 19
Last.John AthertonH-Index: 64
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