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Pallavi Deshpande
Ames testAdverse effectToxicityMedicinePharmacology
10Publications
4H-index
30Citations
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Publications 10
Newest
#1Eleanor SteelsH-Index: 1
#2Elizabeth Steels (University of the Sunshine Coast)
Last. Trudi Collet (QUT: Queensland University of Technology)H-Index: 8
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Abstract Objectives The aim of the study was to assess the safety and efficacy of a nasal spray containing a polyphenol-rich standardized extract of cinnamon bark (Cinnamomum zeylanicum) (IND02) for the treatment of seasonal allergic rhinitis (SAR). Methods This study was a randomized, double-blind, placebo-controlled study conducted in otherwise healthy men and women, aged between 18 and 75 years old, who were experiencing acute SAR symptoms. Participants were randomized in a 1:1 ratio to a nas...
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#1Colin Wilborn (University of Mary Hardin–Baylor)H-Index: 22
#2Sara Hayward (University of Mary Hardin–Baylor)H-Index: 7
Last. Prasad A. ThakurdesaiH-Index: 18
view all 8 authors...
Objective: To assess the efficacy of a proprietary blend rich in glycoside based standardized fenugreek seed extract (400 mg) and minor quantities of curcumin and cinnamon (25 mg each) supplementation (IBPR) on inflammatory markers related to skeletal muscle soreness using double-blind placebo control, parallel design. Methods: A total of 20 healthy non-resistance trained young male and female subjects were assigned to ingest either IBPR or matching placebo for 14 days before the eccentric exerc...
1 CitationsSource
#1Pallavi DeshpandeH-Index: 4
#2Vishwaraman MohanH-Index: 14
Last. Prasad A. ThakurdesaiH-Index: 18
view all 3 authors...
Objective: To evaluate acute oral toxicity (AOT), subchronic (90-day repeated dose) toxicity, mutagenicity, and genotoxicity potential of IDM01, the botanical composition of 4-hydroxyisoleucine- and trigonelline-based standardized fenugreek ( Trigonella foenum-graecum L) seed extract in laboratory rats. Materials and Methods: The AOT and subchronic (90-day repeated dose) toxicity were evaluated using Sprague-Dawley rats as per the Organisation for Economic Co-operation and Development (OECD) gui...
2 CitationsSource
#1Pallavi DeshpandeH-Index: 4
#2Vishwaraman MohanH-Index: 14
Last. Prasad A. ThakurdesaiH-Index: 18
view all 5 authors...
Context: Glycoside-based standardized fenugreek seed extract (SFSE-G) demonstrated promising efficacy in animal models of immune-inflammatory conditions. Aim : The present study was aimed at embryo-fetal development toxicity evaluation of SFSE-G in Wistar rats as per guideline No. 414 of the Organization for Economic Co-operation and Development (OECD). Material and Methods: Mated female rats were randomized into four groups of 30 each and received oral doses of either SFSE-G at 250, 500, and 10...
4 CitationsSource
ABSTRACTThe present work is aimed at studying acute oral toxicity (AOT), subchronic oral toxicity, mutagenicity, and genotoxicity of furostanol glycosides-based standardized fenugreek seed extract ...
3 CitationsSource
Objective : To evaluate prenatal safety of furostanol saponin glycoside based standardized fenugreek seed extract (Fenu-FG) on pregnant female Wistar rats on embryo–fetal development organogenesis period in accordance with OECD guideline (No. 414). Methods : Fenu-FG was administered to pregnant rats by gavage at 250, 500, and 1000 mg/kg/day over the exposure period of gestational days 5–19. The vehicle control (VC) group was also maintained. All dams were subjected to a cesarean section on gesta...
2 CitationsSource
#1Pallavi DeshpandeH-Index: 4
#2Vishwaraman MohanH-Index: 14
Last. Prasad A. ThakurdesaiH-Index: 18
view all 3 authors...
The objective of the present study was to evaluate acute oral toxicity, subchronic toxicity, and mutagenic potential of low molecular weight galactomannans based standardized fenugreek seeds extract (LMWGAL-TF) in laboratory animals rats as per Organization for Economic Co-operation and Development (OECD) guidelines. For the acute toxicity (AOT) study, LMWGAL-TF was orally administered to Sprague-Dawley (SD) rats at a dose of 2000 mg/kg with vehicle control (VC) group (n = 5 per sex per group) a...
5 CitationsSource
Objective: To evaluate the prenatal developmental toxicity of low molecular weight galactomannans based standardized fenugreek seed extract (LMWGAL-TF). Methods: Rats received oral administration of LMWGAL-TF (250, 500 and 1000 mg/kg) during the period of gestation from day 5 (implantation day)–19 (1 d before expected day of parturition) post conception. Maternal, embryo, and fetal toxicity parameters were evaluated. Results: LMWGAL-TF exposure did not produce maternal (clinical observations, bo...
2 Citations
Objective: To evaluate acute oral toxicity (AOT), subchronic toxicity, and mutagenic potential of glycosides based standardized fenugreek (Trigonella foenum graecum L.) seeds extract (SFSE-G). Materials and Methods: The AOT, subchronic (90-day repeated dose) toxicity and mutagenicity (reverse mutation test) of oral administration of SFSE-G were evaluated using Sprague-Dawley (SD) rats as per OECD guideline no. 423, No. 408 and 471 respectively. Results: The SFSE-G did not show mortality or treat...
4 CitationsSource
#1Pallavi DeshpandeH-Index: 4
#2Vishwaraman MohanH-Index: 14
Last. Prasad A. ThakurdesaiH-Index: 18
view all 3 authors...
Context: Centella asiatica (CA) leaves extract has been shown therapeutic potential. However, safety information is lacking. Aims: To evaluate acute oral toxicity (AOT), sub-chronic toxicity, and mutagenic potential of standardized extract of CA (L.) Urban leaves (INDCA). Materials and Methods: For the acute toxicity study, INDCA was orally administered to Sprague-Dawley rats at a dose range of 0–2000 mg/kg. For the repeated dose toxicity study, the rats of either sex were orally administered wi...
7 CitationsSource
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