Paul Spearman
Cincinnati Children's Hospital Medical Center
Molecular biologyVirologyImmunologyVirusBiology
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Publications 135
#1Krishnan Roskin (Cincinnati Children's Hospital Medical Center)
#2Paul Spearman (Cincinnati Children's Hospital Medical Center)H-Index: 38
Broadly neutralizing antibodies (bnAbs) against HIV-1 provide critical insights into co-evolution between the virus and human B cell responses. In this issue of Cell Host & Microbe, Shen et al. (2020) describe a rare mutation in an antibody lineage targeting the fusion peptide of HIV-1 envelope creating a critical bifurcation, with only one path leading to bnAb development.
#1Karnail Singh (University of Cincinnati Academic Health Center)H-Index: 15
#1Karnail SinghH-Index: 1
Last. Paul SpearmanH-Index: 38
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The 2013-2016 Ebola outbreak in West Africa led to accelerated efforts to develop vaccines against these highly virulent viruses. A live, recombinant vesicular stomatitis virus-based vaccine has been deployed in outbreak settings and appears highly effective. Vaccines based on replication-deficient adenovirus vectors either alone or in combination with a multivalent modified vaccinia Ankara (MVA) Ebola vaccine also appear promising and are progressing in clinical evaluation. However, the ability...
#1Mohammad Ali Rai (UC: University of Cincinnati)H-Index: 1
#2Jason Hammonds (Cincinnati Children's Hospital Medical Center)H-Index: 15
Last. Paul Spearman (Cincinnati Children's Hospital Medical Center)H-Index: 38
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#1Riza Ikranbegiin (WHO: World Health Organization)
#2George P. Schmid (CDC: Centers for Disease Control and Prevention)H-Index: 33
Last. Adilya Albetkova (CDC: Centers for Disease Control and Prevention)H-Index: 2
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We review the current state of quality assurance in laboratories of the five Central Asia Republics (CARs), focusing on laboratory equipment, and compare quality assurance approaches with CLSI standards. The laboratories of the CARs faced exceptional challenges including highly-structured laboratory systems that retain centralized and outmoded Soviet-era approaches to quality assurance, considerably jeopardizing the validity of laboratory tests. The relative isolation of the CARs, based on geogr...
#1Paul Spearman (Cincinnati Children's Hospital Medical Center)H-Index: 38
#2Georgia D. Tomaras (Duke University)H-Index: 60
Last. Susan W. Barnett (Novartis)H-Index: 47
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#1Cindy Buffone (Albert Einstein College of Medicine)H-Index: 7
#2Juliane Kutzner (University Hospital Heidelberg)H-Index: 5
Last. Felipe Diaz-Griffero (Albert Einstein College of Medicine)H-Index: 38
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Abstract SAMHD1 is a human restriction factor known to prevent infection of macrophages, resting CD4+ T cells, and dendritic cells by HIV-1. To test the contribution of MxB to the ability of SAMHD1 to block HIV-1 infection, we created human THP-1 cell lines that were knocked out for expression of MxB, SAMHD1, or both. Interestingly, MxB depletion renders SAMHD1 ineffective against HIV-1 but not SIVmac. We observed similar results in human primary macrophages that were knockdown for the expressio...
1 CitationsSource
#1Janet R. Gilsdorf (UM: University of Michigan)H-Index: 26
#2Paul Spearman (Cincinnati Children's Hospital Medical Center)H-Index: 38
Last. Kristina Bryant (University of Louisville)H-Index: 16
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#1Katherine V. Houser (NIH: National Institutes of Health)H-Index: 5
#2Galina Yamshchikov (NIH: National Institutes of Health)H-Index: 10
Last. Julie E. Ledgerwood (NIH: National Institutes of Health)H-Index: 37
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Background Children are susceptible to severe influenza infections and facilitate community transmission. One potential strategy to improve vaccine immunogenicity in children against seasonal influenza involves a trivalent hemagglutinin DNA prime-trivalent inactivated influenza vaccine (IIV3) boost regimen. Methods Sites enrolled adolescents, followed by younger children, to receive DNA prime (1 mg or 4 mg) intramuscularly by needle-free jet injector (Biojector), followed by split virus 2012/13 ...
4 CitationsSource
#1Paul Spearman (Emory University)H-Index: 38
#1Paul Spearman (Cincinnati Children's Hospital Medical Center)H-Index: 38