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Cheng Lu
Hong Kong Baptist University
121Publications
23H-index
1,715Citations
Publications 121
Newest
#1Chao Liang (Hong Kong Baptist University)H-Index: 16
#2Jie Li (CUHK: The Chinese University of Hong Kong)H-Index: 6
Last.Aiping LuH-Index: 34
view all 18 authors...
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by progressive bone erosion. Leflunomide is originally developed to suppress inflammation via its metabolite A77 1726 to attenuate bone erosion. However, distinctive responsiveness to Leflunomide is observed among RA individuals. Here we show that Leflunomide exerts immunosuppression but limited efficacy in RA individuals distinguished by higher serum C-reactive protein (CRPHigher, CRPH), whereas the others with satisfact...
#1Chi Zhang (Hong Kong Baptist University)H-Index: 11
#2Daogang Guan (Hong Kong Baptist University)H-Index: 12
Last.Aiping Lu (Hong Kong Baptist University)H-Index: 34
view all 12 authors...
Leflunomide (LEF) is a first-line disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis (RA). However, there are still a few nonresponders. It is logical to suggest that employing combinations including LEF that produce synergistic effects in terms of pharmacological activity is a promising strategy to improve clinical outcomes. We propose a novel approach for predicting LEF combinations through investigating the potential effects of drug targets on the disease signaling network....
#1Heru Zhao (Yichun University)
#2Yin Zhang (Yichun University)H-Index: 1
Last.Aiping Lu (Hong Kong Baptist University)H-Index: 34
view all 15 authors...
Background: Rheumatoid arthritis (RA) is an autoimmune disease. Based on traditional Chinese medicine (TCM) theory, deficiency pattern (DP) which leads to specific treatment principles in clinical management is crucial pattern diagnosis among RA patients, and autoantibodies have potential implications in TCM pattern classification. The purpose of this study was to identify specific RA DP-associated autoantibodies. Methods: RA DP patients, RA nondeficiency pattern (NDP) patients and healthy contr...
#1Xiaojuan HeH-Index: 18
#2Jin Liu (Hong Kong Baptist University)H-Index: 15
Last.Aiping LuH-Index: 34
view all 19 authors...
Abstract Background Osteoblasts participating in the inflammation regulation gradually obtain concerns. However, its role in joint inflammation of rheumatoid arthritis (RA) is largely unknown. Here, we investigated the role of osteoblastic pleckstrin homology domain-containing family O member 1 (PLEKHO1), a negative regulator of osteogenic lineage activity, in regulating joint inflammation in RA. Methods The level of osteoblastic PLEKHO1 in RA patients and collagen-induced arthritis (CIA) mice w...
#1Chao Liang (Hong Kong Baptist University)H-Index: 16
#2Songlin Peng (Hong Kong Baptist University)H-Index: 9
Last.Ge Zhang (Hong Kong Baptist University)H-Index: 32
view all 15 authors...
Bone morphogenetic protein (BMP) signaling is essential for osteogenesis. However, recombinant human BMPs (rhBMPs) exhibit large inter-individual variations in local bone formation during clinical spinal fusion. Smurf1 ubiquitinates BMP downstream molecules for degradation. Here, we classify age-related osteoporosis based on distinct intraosseous BMP-2 levels and Smurf1 activity. One major subgroup with a normal BMP-2 level and elevated Smurf1 activity (BMP-2n/Smurf1e) shows poor response to rhB...
The potential toxicity of herbal drugs, particularly drug-induced liver injury (DILI), has received extensive attention as the use of Chinese herbal medicine has rapidly increased globally. As a classic Chinese patent medicine, Zhuang Gu Guan Jie Wan (ZGGJW) has been brought into focus recently because of its satisfactory therapeutic effects on osteoarthritis (OA) as well as its unanticipated side effects. This study aimed to decipher the puzzling phenomenon of liver injury developing in respons...
#1Xuemei Qiu (Southwest Jiaotong University)H-Index: 3
#2Qingqing Guo (Hong Kong Baptist University)H-Index: 4
Last.Aiping Lu (SHU: Shanghai University)H-Index: 34
view all 11 authors...
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), characterized by infiltrating inflammatory cells and demyelinating lesions, and T helper (Th) cells play critical roles in the pathogenesis of MS. There is still lack of effective treatments currently. Pien Tze Huang (PZH), a traditional Chinese medicine formula, has been proved to have anti-inflammatory, neuroprotective and immunoregulatory effects. However, whether PZH can be used to treat MS is still obscure...
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