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Guo Xiao Wang
University of Michigan
8Publications
8H-index
408Citations
Publications 8
Newest
#1Siming Li (UM: University of Michigan)H-Index: 7
#2Lin Mi (UM: University of Michigan)H-Index: 4
Last.Jiandie D. Lin (UM: University of Michigan)H-Index: 38
view all 9 authors...
Abstract Brown and beige adipocytes convert chemical energy into heat through uncoupled respiration to defend against cold stress. Beyond thermogenesis, brown and beige fats engage other metabolic tissues via secreted factors to influence systemic energy metabolism. How the protein and long noncoding RNA (lncRNA) regulatory networks act in concert to regulate key aspects of thermogenic adipocyte biology remains largely unknown. Here we developed a genome-wide functional screen to interrogate the...
#1Zhimin Chen (UM: University of Michigan)H-Index: 4
#2Guo Xiao Wang (UM: University of Michigan)H-Index: 8
Last.Jiandie D. Lin (UM: University of Michigan)H-Index: 38
view all 14 authors...
Abstract Objective Brown and white adipose tissue exerts pleiotropic effects on systemic energy metabolism in part by releasing endocrine factors. Neuregulin 4 (Nrg4) was recently identified as a brown fat-enriched secreted factor that ameliorates diet-induced metabolic disorders, including insulin resistance and hepatic steatosis. However, the physiological mechanisms through which Nrg4 regulates energy balance and glucose and lipid metabolism remain incompletely understood. The aims of the cur...
#1Guo Xiao Wang (UM: University of Michigan)H-Index: 8
#2Xu Yun Zhao (UM: University of Michigan)H-Index: 5
Last.Jiandie D. Lin (UM: University of Michigan)H-Index: 38
view all 3 authors...
Brown fat is highly active in fuel oxidation and dissipates chemical energy through uncoupling protein (UCP)1-mediated heat production. Activation of brown fat leads to increased energy expenditure, reduced adiposity, and lower plasma glucose and lipid levels, thus contributing to better homeostasis. Uncoupled respiration and thermogenesis have been considered to be responsible for the metabolic benefits of brown adipose tissue. Recent studies have demonstrated that brown adipocytes also secrete...
#1Guo Xiao Wang (UM: University of Michigan)H-Index: 8
#2Xu Yun Zhao (Life Sciences Institute)H-Index: 1
Last.Jiandie D. Lin (Life Sciences Institute)H-Index: 38
view all 13 authors...
The brown fat-derived neuregulin 4 regulates hepatic lipid homeostasis and whole-body insulin sensitivity
#1Xu Yun Zhao (UM: University of Michigan)H-Index: 5
#2Siming Li (UM: University of Michigan)H-Index: 7
Last.Jiandie D. Lin (UM: University of Michigan)H-Index: 38
view all 5 authors...
Brown and beige/brite fats generate heat via uncoupled respiration to defend against cold. The total mass and activity of thermogenic adipose tissues are also tightly linked to systemic energy and nutrient homeostasis. Despite originating from distinct progenitors, brown and beige adipocytes acquire remarkably similar molecular and metabolic characteristics during differentiation through the action of a network of transcription factors and cofactors. How this regulatory network interfaces with l...
#1Guo Xiao Wang (UM: University of Michigan)H-Index: 8
#2Kae Won Cho (UM: University of Michigan)H-Index: 14
Last.Jiandie D. Lin (UM: University of Michigan)H-Index: 38
view all 11 authors...
Chronic low-grade inflammation is emerging as a pathogenic link between obesity and metabolic disease. Persistent immune activation in white adipose tissue (WAT) impairs insulin sensitivity and systemic metabolism, in part, through the actions of proinflammatory cytokines. Whether obesity engages an adaptive mechanism to counteract chronic inflammation in adipose tissues has not been elucidated. Here we identified otopetrin 1 (Otop1) as a component of a counterinflammatory pathway that is induce...
#1Siming Li (UM: University of Michigan)H-Index: 7
#2Qi Yu (UM: University of Michigan)H-Index: 3
Last.Jiandie D. Lin (UM: University of Michigan)H-Index: 38
view all 4 authors...
The biological clock plays an important role in integrating nutrient and energy metabolism with other cellular processes. Previous studies have demonstrated that core clock genes are rhythmically expressed in peripheral tissues, including the liver, skeletal muscle, pancreatic islets, and white and brown adipose tissues. These peripheral clocks are entrained by physiological cues, thereby aligning the circadian pacemaker to tissue functions. The mechanisms that regulate brown adipose tissue cloc...
#1Zhuo Xian Meng (UM: University of Michigan)H-Index: 13
#2Guo Xiao Wang (UM: University of Michigan)H-Index: 8
Last.Jiandie D. Lin (UM: University of Michigan)H-Index: 3
view all 3 authors...
Macrophages play an important role in tissue repair and remodeling and innate immune response. Tissue macrophages are highly heterogeneous and can undergo two distinct programs of functional specification termed classical (M1) and alternative (M2) activation1,2. In response to signals elicited by bacterial infections, such as lipopolysaccharide (LPS) and interferon-γ (IFN-γ), macrophages adopt a pro-inflammatory phenotype and contribute to defense against invading pathogens through phagocytosis,...
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