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Hong Wang
Kunming University of Science and Technology
24Publications
9H-index
992Citations
Publications 24
Newest
Published on Mar 27, 2019in National Science Review13.22
Lei Shi9
Estimated H-index: 9
(KIZ: Kunming Institute of Zoology),
Xin Luo1
Estimated H-index: 1
+ 17 AuthorsYanjiao Li1
Estimated H-index: 1
(KIZ: Kunming Institute of Zoology)
Published on Mar 1, 2018in Cell Research17.85
Yiqiang Cui9
Estimated H-index: 9
,
Yuyu Niu15
Estimated H-index: 15
+ 12 AuthorsBo Zheng8
Estimated H-index: 8
Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination
Published on Feb 12, 2018in PeerJ2.35
Xufeng Fu1
Estimated H-index: 1
(Kunming University of Science and Technology),
Bin Jiang4
Estimated H-index: 4
(UM: University of Macau)
+ 11 AuthorsBingbing Chen1
Estimated H-index: 1
(Kunming University of Science and Technology)
Published on Dec 1, 2017in Theriogenology2.30
Bingbing Chen1
Estimated H-index: 1
(Kunming University of Science and Technology),
Shanshan Li1
Estimated H-index: 1
(Kunming University of Science and Technology)
+ 6 AuthorsWei Si10
Estimated H-index: 10
(Kunming University of Science and Technology)
Abstract The cryoprotective agent (CPA) is one of the most important factors that affects the cryosurvival of sperm. The aim of the present study was to compare two different CPAs, glycerol (Gly) and ethylene glycol (EG), on the cryopreservation of cynomolgus macaques sperm and evaluate the effects of cryopreservation on sperm motility, acrosomal integrity, DNA integrity, mitochondrial function and the sperm membrane ion channels CatSper and Hv1. Compared to fresh sperm, cryopreservation with ei...
Published on Apr 1, 2017in Cell Research17.85
Fei Gao11
Estimated H-index: 11
,
Yuyu Niu15
Estimated H-index: 15
(Kunming University of Science and Technology)
+ 13 AuthorsJuehua Yu12
Estimated H-index: 12
(UCLA: University of California, Los Angeles)
Abstract Critical epigenetic regulation of primate embryogenesis entails DNA methylome changes. Here we report genome-wide composition, patterning, and stage-specific dynamics of DNA methylation in pre-implantation rhesus monkey embryos as well as male and female gametes studied using an optimized tagmentation-based whole-genome bisulfite sequencing method. We show that upon fertilization, both paternal and maternal genomes undergo active DNA demethylation, and genome-wide de novo DNA methylatio...
Published on Jan 1, 2017in Stem Cells International3.90
Xufeng Fu1
Estimated H-index: 1
,
Yaping Yan2
Estimated H-index: 2
+ 11 AuthorsDesheng Gong1
Estimated H-index: 1
Mesenchymal stem cells (MSCs) are one of the most promising adult stem cells for clinical application in a cell therapy. The development of large-scale cryopreservation techniques, such as vitrification, for MSCs is a prerequisite for clinical therapies. Dimethyl sulfoxide (DMSO) and ethylene glycol (EG) are two types of cryoprotectants widely used for cell vitrification. However, the effects of DMSO and EG on the biological characteristics and transcriptome profiles of MSCs after cryopreservati...
Published on Jan 1, 2016in Biomaterials10.27
Zongyong Ai5
Estimated H-index: 5
(Kunming University of Science and Technology),
Zheng Xiang3
Estimated H-index: 3
(Kunming University of Science and Technology)
+ 9 AuthorsYanhua Li1
Estimated H-index: 1
Non-human primates provide optimal models for the development of stem cell therapies. Although somatic cells have been converted into neural stem/progenitor cells, it is unclear whether telencephalic neuroepithelial stem cells (NESCs) with stable properties can be generated from fibroblasts in primate. Here we report that a combination of transcription factors (Oct4, Sox2, Klf4) with a new culture medium induces rhesus monkey fibroblasts into NESCs, which can develop into miniature neural tube (...
Published on Dec 20, 2015in Human Molecular Genetics4.54
Yu Kang8
Estimated H-index: 8
(Kunming University),
Bo Zheng8
Estimated H-index: 8
(Nanjing Medical University)
+ 13 AuthorsHong Wang9
Estimated H-index: 9
(Kunming University)
Mutations in the DAX1 locus cause X-linked adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism (HH), which manifest with primary adrenal insufficiency and incomplete or absent sexual maturation, respectively. The associated defects in spermatogenesis can range from spermatogenic arrest to Sertoli cell only syndrome. Conclusions from Dax1 knockout mouse models provide only limited insight into AHC/HH disease mechanisms, because mouse models exhibit more extensive abnormalities in...
Published on Dec 1, 2015in Scientific Reports4.01
Hong Wang9
Estimated H-index: 9
,
Tao Tan9
Estimated H-index: 9
+ 10 AuthorsJianpeng Liao1
Estimated H-index: 1
Alcoholic liver disease (ALD) is a significant public health issue with heavy medical and economic burdens. The aetiology of ALD is not yet completely understood. The development of drugs and therapies for ALD is hampered by a lack of suitable animal models that replicate both the histological and metabolic features of human ALD. Here, we characterize a rhesus monkey model of alcohol-induced liver steatosis and hepatic fibrosis that is compatible with the clinical progression of the biochemistry...
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