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Yukako Yamabe
Kitasato University
5Publications
4H-index
164Citations
Publications 5
Newest
Published on Apr 1, 2007in Molecular Cancer Research 4.48
Kou Horii1
Estimated H-index: 1
,
Yasutomo Suzuki7
Estimated H-index: 7
+ 9 AuthorsSeiichiro Himeno8
Estimated H-index: 8
The androgen receptor (AR) is implicated in prostate cancer growth, progression, and angiogenesis. Hypoxia-inducible factor-1 (HIF-1), which transcriptionally regulates hypoxia-inducible angiogenic factors, is up-regulated in prostate cancers compared with adjacent normal tissues. HIF-1 may be involved in prostate cancer as well as the AR, but the involvement of HIF-1 in prostate cancer angiogenesis and progression has not been fully elucidated. In the present study, we found that in prostate ca...
53 Citations Source Cite
Published on Jan 1, 2001in Journal of Health Science
Yukako Yamabe4
Estimated H-index: 4
(Kitasato University),
Yukihiro Kondo17
Estimated H-index: 17
(Nippon Medical School)
+ 5 AuthorsSeiichiro Himeno16
Estimated H-index: 16
(Kitasato University)
Metallothionein (MT) is known to play an important role in the resistance of tumor cells to cisdiamminedichloroplatinum (II) (CDDP, cisplatin). To identify non-MT factors that play important roles in CDDP resistance, we established CDDP-resistant cell lines from simian virus 40-transformed MT null cells. Subclones of CDDP-resistant MT null cells, designated as MKCr-3, -12, and -18, exhibited 24- to 62-fold resistance to CDDP compared with parental cells. The contents of glutathione (GSH) and the...
4 Citations Source Cite
Published on Dec 1, 2000in Toxicology and Applied Pharmacology 3.58
Yukako Yamabe4
Estimated H-index: 4
(Kitasato University),
Azusa Hoshino1
Estimated H-index: 1
(Kitasato University)
+ 2 AuthorsSeiichiro Himeno16
Estimated H-index: 16
(Kitasato University)
Tributyltin (TBT) and triphenyltin (TPT) are known to cause imposex, the superimposing of male genitals on female ones, in some species of gastropods. However, the molecular mechanism of the trialkyltin-induced endocrine dysfunction remains to be elucidated. To clarify the effects of organotin compounds on the activation of androgen receptor (AR)-mediated responses in mammals, a LA16 clone that stably expresses androgen-responsive luciferase reporter gene and proliferates in response to androgen...
70 Citations Source Cite
Published on Aug 1, 1999in Biochemistry 2.95
Ikue Asahi1
Estimated H-index: 1
,
Nobuhiko Miura14
Estimated H-index: 14
+ 4 AuthorsAkiranaganuma24
Estimated H-index: 24
5 Citations Source Cite
Published on Feb 1, 1999in Life Sciences 3.45
Yukihiro Kondo17
Estimated H-index: 17
(Nippon Medical School),
Takahiro Yanagiya7
Estimated H-index: 7
(Kitasato University)
+ 5 AuthorsNobumasaimura39
Estimated H-index: 39
(Kitasato University)
Abstract Primary cultured embryonic cells derived from mice with disrupted metallothionein (MT) I and II genes and from control mice were transformed with a plasmid encoding the simian virus 40 (SV40) large T antigen. The resulting MT-/- and MT+/+ cell strains showed similar cell morphology, cell cycle and no significant differences in glutathione levels or in the activities of glutathione-related enzymes and antioxidant enzymes. The MT-/- cells were more sensitive to Cd than MT+/+ cells, though...
32 Citations Source Cite
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