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Shelley E. Ackerman
Publications 1
Published on Jan 3, 2017in Journal of Clinical Investigation 12.28
Tracey McLaughlin40
Estimated H-index: 40
Shelley E. Ackerman1
Estimated H-index: 1
+ 1 AuthorsEdgar G. Engleman79
Estimated H-index: 79
Abstract Chronic inflammation in adipose tissue, possibly related to adipose cell hypertrophy, hypoxia, and/or intestinal leakage of bacteria and their metabolic products, likely plays a critical role in the development of obesity-associated insulin resistance (IR). Cells of both the innate and adaptive immune system residing in adipose tissues, as well as in the intestine, participate in this process. Thus, M1 macrophages, IFN-γ-secreting Th1 cells, CD8+ T cells, and B cells promote IR, in part...