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Magdalena Rother
RecombinaseAntibodyB cellV(D)J recombinationLocus (genetics)
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markdownabstractPrecursor-B cells develop in bone marrow (BM) from hematopoietic stem cells (HSC) with the ultimate goal to generate mature B-cells with unique immunoglobulins (Ig), whereby all B cells together provide an enormous Ig repertoire diversity. Formation of the Ig occurs through somatic V(D)J recombination of the Ig heavy chain (IGH) and the Ig light chain (IGK or IGL) loci that contain multiple variable (V), diverse (D) and joining (J) coding elements. The Ig loci recombine in a orde...
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