Chi Hsiung Wang
NorthShore University HealthSystem
Publications 11
#1Hongjie Yu (NorthShore University HealthSystem)H-Index: 8
#2Zhuqing Shi (Fudan University)H-Index: 5
Last.Jianfeng Xu (Fudan University)H-Index: 85
view all 13 authors...
2 CitationsSource
#1Rong Na (Fudan University)H-Index: 13
#2S. Lilly Zheng (NorthShore University HealthSystem)H-Index: 47
Last.William B. Isaacs (Johns Hopkins University)H-Index: 103
view all 37 authors...
Abstract Background Germline mutations in BRCA1/2 and ATM have been associated with prostate cancer (PCa) risk. Objective To directly assess whether germline mutations in these three genes distinguish lethal from indolent PCa and whether they confer any effect on age at death. Design, setting, and participants A retrospective case-case study of 313 patients who died of PCa and 486 patients with low-risk localized PCa of European, African, and Chinese descent. Germline DNA of each of the 799 pati...
62 CitationsSource
#1Madeleine U. Shalowitz (U of C: University of Chicago)H-Index: 19
#2J. S. Eng (NorthShore University HealthSystem)H-Index: 1
Last.E. Nodine (Lake County)H-Index: 1
view all 7 authors...
Food security is related to adult type 2 diabetes control over time in a United States safety net primary care clinic population
4 CitationsSource
#1Rong NaH-Index: 13
#2Siqun Lilly ZhengH-Index: 16
Last.William B. IsaacsH-Index: 103
view all 37 authors...
3 CitationsSource
#1Andrew J. Cohen (U of C: University of Chicago)H-Index: 8
#2Katie Hughes (NorthShore University HealthSystem)H-Index: 2
Last.Sangtae Park (NorthShore University HealthSystem)H-Index: 3
view all 6 authors...
Objective To determine the variance in computeed tomography (CT) radiation measured via dose-length product (DLP) and effective dose (ED) during stone protocol CT scans. Methods We retrospectively examined consecutive records of patients receiving stone protocol diagnostic CT scans (n = 1793) in 2010 and 2014 in our health system. Patient age, body mass index (BMI), and gender were recorded, along with the hospital, machine model, year, DLP, and ED of each scan. Multivariate regression was perfo...
4 CitationsSource
#1Yuefeng Yang (U of C: University of Chicago)H-Index: 11
#2Weidong Xu (U of C: University of Chicago)H-Index: 4
Last.Prem Seth (U of C: University of Chicago)H-Index: 16
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The development of novel therapies for breast cancer bone metastasis is a major unmet medical need. Toward that end, we have constructed an oncolytic adenovirus, Ad.dcn, and a nonreplicating adenovirus, Ad(E1-).dcn, both containing the human decorin gene. Our in vitro studies showed that Ad.dcn produced high levels of viral replication and the decorin protein in the breast tumor cells. Ad(E1-).dcn-mediated decorin expression in MDA-MB-231 cells downregulated the expression of Met, β-catenin, and...
26 CitationsSource
#2Chi Hsiung WangH-Index: 5
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#1Christina G. Selkirk (NorthShore University HealthSystem)H-Index: 8
#2Chi Hsiung Wang (NorthShore University HealthSystem)H-Index: 5
Last.Brian T. Helfand (NorthShore University HealthSystem)H-Index: 33
view all 4 authors...
Objective To assess whether men with a family history of prostate cancer are more likely to fail active surveillance because of recategorization of their tumors on subsequent surveillance biopsies. Methods Men enrolled in an institutional review board–approved active surveillance program were studied, and data on first- and/or second-degree family history of prostate cancer was collected. Analyses were performed to compare the frequency of family history with recategorization (higher grade or vo...
5 CitationsSource
#1Hemant K. Roy (BMC: Boston Medical Center)H-Index: 35
#2Charles B. Higgins (NorthShore University HealthSystem)H-Index: 97
Last.Vadim Backman (NU: Northwestern University)H-Index: 48
view all 14 authors...
Purpose To determine whether nano-architectural interrogation of prostate field carcinogenesis can be used to predict prognosis in patients with early stage (Gleason 6) prostate cancer (PCa), which is mostly indolent but frequently unnecessarily treated.
21 CitationsSource
#1Weidong XuH-Index: 4
#2Zhenwei ZhangH-Index: 5
Last.Prem SethH-Index: 16
view all 14 authors...
We are interested in developing oncolytic adenoviruses for the treatment of prostate cancer (PCa) bone metastases. A key limitation of Adenovirus 5 (Ad5) is that upon systemic administration, it produces major liver and systemic toxicities. To address this issue, a chimaeric Ad5/48 adenovirus mHAd.sTβRFc was created. Seven hypervariable regions of Ad5 hexon present in Ad5-based Ad.sTβRFc expressing soluble transforming growth factor beta receptorII-Fc fusion protein (sTGβRIIFc), were replaced by...
10 CitationsSource