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C Righeschi
University of Florence
BioavailabilityLiposomeSolid lipid nanoparticleCurcuminPharmacology
15Publications
8H-index
349Citations
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Publications 15
Newest
#1Isabella Leto (UniFI: University of Florence)H-Index: 2
#2Marcella Coronnello (UniFI: University of Florence)H-Index: 14
Last. Anna Rita Bilia (UniFI: University of Florence)H-Index: 36
view all 6 authors...
Artemisinin (ART) is a unique sesquiterpene lactone isolated from Artemisia annua that is well known for antimalarial properties and was recently reported as a promising anticancer drug. The aim of our work was to develop a novel nanocarrier for enhanced ART delivery and activation in cancer tissues, because transferrin receptors are largely expressed in cancer cells and the iron content is higher than in normal cells. ART was loaded in transferrin-conjugated liposomes (ART-L-Tf), and the perfor...
11 CitationsSource
#1C Righeschi (UniFI: University of Florence)H-Index: 8
#2Maria Camilla Bergonzi (UniFI: University of Florence)H-Index: 22
Last. Anna Rita Bilia (UniFI: University of Florence)H-Index: 36
view all 6 authors...
Abstract Curcumin health benefits are strongly limited by its poor aqueous solubility and low oral bioavailability. This work was focused on the development and characterization of solid lipid nanoparticles (SLNs) for the encapsulation of curcumin for oral administration. High shear homogenization and ultrasonication techniques were employed to prepare Compritol SLNs. The physicochemical characterization of round shaped curcumin-loaded SLNs was carried out by monitoring particle size (lower than...
29 CitationsSource
#2C RigheschiH-Index: 8
Last. Anna Rita BiliaH-Index: 36
view all 4 authors...
1 CitationsSource
#1C RigheschiH-Index: 8
#2Marcella CoronnelloH-Index: 14
Last. Anna Rita BiliaH-Index: 36
view all 5 authors...
1 CitationsSource
#1Anna Rita Bilia (UniFI: University of Florence)H-Index: 36
#2Benedetta IsacchiH-Index: 16
Last. Maria Camilla BergonziH-Index: 22
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Flavonoids are among the biggest group of polyphenols, widely distributed in plant-based foods. A plethora of evidence supports the health benefits and value of flavonoids can play in the physiological function treatment and in the prevention of disease particularly in the prevention of degenerative conditions including cancers, cardiovascular and neurodegenerative diseases. Hence, flavonoids represent the active constituents of many dietary supplements and herbal remedies, as well as there is a...
38 CitationsSource
#1Anna Rita Bilia (UniFI: University of Florence)H-Index: 36
#2Clizia GuccioneH-Index: 7
Last. Maria Camilla BergonziH-Index: 22
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Essential oils are complex blends of a variety of volatile molecules such as terpenoids, phenol-derived aromatic components, and aliphatic components having a strong interest in pharmaceutical, sanitary, cosmetic, agricultural, and food industries. Since the middle ages, essential oils have been widely used for bactericidal, virucidal, fungicidal, antiparasitical, insecticidal, and other medicinal properties such as analgesic, sedative, anti-inflammatory, spasmolytic, and locally anaesthetic rem...
136 CitationsSource
#1C Righeschi (UniFI: University of Florence)H-Index: 8
#2Marcella Coronnello (UniFI: University of Florence)H-Index: 14
Last. Anna Rita Bilia (UniFI: University of Florence)H-Index: 36
view all 7 authors...
Abstract Dihydroartemisinin is one of the most potent anticancer artemisinin-like compounds, able to induce cancer cell death by apoptotic pathways. Besides its effectiveness, it is a poorly water soluble drug with low bioavailability and low half-life (34–90 min), therefore, the development of new formulations of dihydroartemisinin to increase bioavailability is in great need. Conventional (P90G and cholesterol) and stealth liposomes (P90G; cholesterol and PE 18:0/18:0 PEG 2000) to deliver dihy...
17 CitationsSource
#1C RigheschiH-Index: 8
Last. Anna Rita BiliaH-Index: 36
view all 4 authors...
1 CitationsSource
#1C RigheschiH-Index: 8
#2Marcella CoronnelloH-Index: 14
Last. Anna Rita BiliaH-Index: 36
view all 5 authors...
Source
#1Maria Camilla Bergonzi (UniFI: University of Florence)H-Index: 22
#2C Righeschi (UniFI: University of Florence)H-Index: 8
Last. Anna Rita Bilia (UniFI: University of Florence)H-Index: 36
view all 4 authors...
Abstract A simple, rapid and specific HPLC method was carried out for the analysis of characteristic constituents in Gardenia jasminoides Ellis (Zhizi), namely iridoids, caffeoyl quinic acid derivatives and crocins. The separation was successfully obtained using a C 18 column by gradient elution with mixtures of methanol and water as mobile phases; detection wavelength was set at 240 nm for iridoid glycosides, 315 nm for quinic acid derivatives and 438 nm for crocins. The analytical method was v...
35 CitationsSource
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