Liping Chung
University of Sydney
MRN complexRad50Radiation therapyColorectal cancerBiomarker (medicine)
What is this?
Publications 5
The DNA damage response enables cells to survive and maintain genome integrity. RAD52 is a DNA-binding protein involved in the homologous recombination in DNA repair, and is important for the maintenance of tumour genome integrity. We investigated possible correlations between RAD52 expression and cancer survival and response to preoperative radiotherapy. RAD52 expression was examined in tumour samples from 179 patients who underwent surgery for rectal cancer, including a sub-cohort of 40 patien...
The MRE11-RAD50-NBS1 (MRN) complex has been studied in multiple cancers. The identification of MRN complex mutations in mismatch repair (MMR)-defective cancers has sparked interest in its role in colorectal cancer (CRC). To date, there is evidence indicating a relationship of MRN expression with reduced progression-free survival, although the significance of the MRN complex in the clinical setting remains controversial. In this review, we present an overview of the function of the MRN complex, i...
4 CitationsSource
#1Vincent T. Ho (USYD: University of Sydney)H-Index: 71
#2Liping Chung (USYD: University of Sydney)H-Index: 3
Last. C. Soon LeeH-Index: 39
view all 11 authors...
The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing the three-protein panel of MRN complex subunits as a potential radiosensitivity marker and evaluating the prognostic and clinicopathological implications of MRN expression in rectal cancer. Samples from 265 rectal cancer ...
4 CitationsSource
#1Vincent T. HoH-Index: 71
#2Liping ChungH-Index: 3
Last. C. Soon LeeH-Index: 39
view all 12 authors...
Background: Molecular biomarkers have the potential to predict response to the treatment of rectal cancer. In this study, we aimed to evaluate the prognostic and clinicopathological implication of RAD50 (DNA repair protein RAD50 homolog) expression in rectal cancer. Methods: A total of 266 rectal cancer patients who underwent surgery and received chemo- and radiotherapy between 2000 and 2011 were involved in the study. Postoperative RAD50 expression was determined by immunohistochemistry in surg...
2 CitationsSource
#1Vincent T. HoH-Index: 71
#2Liping ChungH-Index: 3
Last. Joo-Shik ShinH-Index: 10
view all 14 authors...
Background Aberrant expression of DNA repair proteins is associated with poor survival in cancer patients. We investigated the combined expression of MRE11 and ATM as a predictive marker of response to radiotherapy in rectal cancer.
8 CitationsSource