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Hong Zhang
Shanghai Jiao Tong University
EndocrinologyInsulin resistanceObesityDiabetes mellitusMedicine
8Publications
4H-index
32Citations
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Publications 10
Newest
#1Chen Wang (SJTU: Shanghai Jiao Tong University)H-Index: 13
#2Hong Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Cheng Hu (SJTU: Shanghai Jiao Tong University)H-Index: 29
view all 7 authors...
Abstract Background Alterations in gut microbiota have been associated with improvements in blood glucose due to bariatric surgery. Objectives Our aim is to identify specific gut microbiota that contribute to the remission of T2D after RYGB and SG. Methods Rats fed a high-fat diet (HFD) were administered a low dose of streptozotocin as T2D models; next, their caecum content was collected 8 weeks after RYGB and SG. We also used case-control of gut microbial profiles of T2D patients and healthy pe...
Source
#1Yeping Huang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Hong Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Cheng Hu (Southern Medical University)H-Index: 29
view all 6 authors...
Abstract Background Iron deficiency is extremely common after bariatric surgery. HEPCIDIN, encoded by Hamp, is a hormone that negatively regulates iron homeostasis. Objective We aimed to investigate the alteration of Hamp expression and related regulatory factors to explore the probable role of DNA methylation in modulating Hamp expression in the context of iron deficiency after bariatric surgery. Setting Laboratories of Diabetes Institute. Methods RNA-seq was performed using rat liver tissue af...
1 CitationsSource
#1Yeping Huang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Yan Huang (NU: Nanjing University)
Last. Cheng Hu (Southern Medical University)H-Index: 29
view all 6 authors...
Abstract Aims We investigated whether serum haptoglobin (Hp) levels play a role in the development and progression of diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients in a Chinese Han population, which has not been previously investigated. Methods We recruited 233 participants who had suffered from T2DM for more than 10 years, including 118 subjects with DKD (case) and 115 subjects without DKD (control). Serum Hp levels were measured by an enzyme-linked immunosorbent ass...
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#1Hong Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Ying Chang (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Weiping Jia (SJTU: Shanghai Jiao Tong University)H-Index: 58
view all 6 authors...
The gut microbiota plays an important role in the development and progression of colorectal cancer (CRC). To learn more about the dysbiosis of carcinogenesis, we assessed alterations in gut microbiota in patients with CRC. A total of 23 subjects were enrolled in this study: 9 had CRC (CRC group) and 14 had normal colons (normal group). The microbiome of the mucosal—luminal interface of each subject was sampled and analyzed using 16S rRNA gene amplicon sequencing. We also used Phylogenetic Invest...
5 CitationsSource
#1Yangyang Li (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Hong Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Cheng Hu (SJTU: Shanghai Jiao Tong University)H-Index: 29
view all 11 authors...
Objectives Bariatric surgery is emerging as the most effective treatment option for patients with obesity. Hypothalamic arcuate nucleus plays an important role in metabolic homeostasis. However, the influence of mutations related to the feeding center on weight loss after bariatric surgery is still unclear. We aimed to diagnose monogenic obesity by whole exome sequencing (WES) and explore whether monogenic mutations influence the effectiveness of bariatric surgery.
2 CitationsSource
#1Zhen He (Southern Medical University)H-Index: 6
#2Rong Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 25
Last. Cheng Hu (Southern Medical University)H-Index: 29
view all 11 authors...
Background Genome-wide association studies (GWASs) have shown that genetic variants are important determinants of free fatty acid levels. The mechanisms underlying the associations between genetic variants and free fatty acid levels are incompletely understood. Here, we aimed to identify genetic markers that could influence diverse fatty acid levels in a Chinese population and uncover the molecular mechanisms in terms of DNA methylation and gene expression.
6 CitationsSource
#1Tao Wang (SJTU: Shanghai Jiao Tong University)H-Index: 10
#2Rong Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 25
Last. Weiping JiaH-Index: 58
view all 13 authors...
OBJECTIVE: This study aimed to compare the causal effect of overall obesity and abdominal obesity on type 2 diabetes among Chinese Han individuals. METHODS: The causal relationship of BMI and waist-to-hip ratio (WHR) with the risk of glucose deterioration and glycemic traits was compared using two different genetic instruments based on 30 BMI loci and 6 WHR loci with Mendelian randomization (MR) in three prospective cohorts (n = 6,476). RESULTS: Each 1-SD genetically instrumented higher WHR was ...
7 CitationsSource
#1Jiejie Zhao (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Xuelian Xiong (Ministry of Education)H-Index: 2
Last. Xiaoying Li (Ministry of Education)H-Index: 2
view all 16 authors...
Type 2 diabetes has become one of the most serious and long-term threats to human health. However, the molecular mechanism that links obesity to insulin resistance remains largely unknown. Here, we show that F-box and WD repeat domain-containing 7 (FBXW7), an E3 ubiquitin-protein ligase, is markedly downregulated in the liver of two obese mouse models and obese human subjects. We further identify a functional low-frequency human FBXW7 coding variant (p. Ala204Thr) in Chinese population, which is...
11 CitationsSource
#1Yang LüH-Index: 1
#2Hong ZhangH-Index: 4
Last. Po ZhaoH-Index: 1
view all 4 authors...
Objective To investigate the expression of DNA dependent protein kinase catalytic subunit (DNA-PKcs) and P16 (multiple tumor suppressor 1 ) genes in colorectal carcinoma and clinical significance thereof. Methods 359 specimens of colorectal carcinoma obtained during operation and 35 specimens of normal mucosa beside the carcinoma underwent immunohistochemical examination and Western blotting to detect the expression of DNA-PKcs and P16. Results The positive expression rates of DNA-PKcs and P16 o...
2 Citations
#1Hong Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Wei JiaH-Index: 59
Last. Xiang KsH-Index: 2
view all 9 authors...
Objective To investigate the effect of single nucleotide polymorphism (SNP)+45 of the adiponeetin (ADIPOQ) gene on the response to therapy with rosiglitazone maleate in patients with type 2 diabetes.Methods A total of 103 newly diagnosed type 2 diabetes patients without taking any drug were enrolled and treated with rosiglitazone maleate (4 or 8 mg/d) for 24 weeks.On scheduled time phenotype measured were height,weight,waist,hip;blood pressure;HbAlc;plasma glucose level,serum insulin level,serum...
2 Citations
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