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Gabriela Manzano-Nieves
Brown University
6Publications
4H-index
95Citations
Publications 5
Newest
#1Haley L. Goodwill (Brown University)H-Index: 4
#2Gabriela Manzano-Nieves (Brown University)H-Index: 4
Last.Kevin G. Bath (Brown University)H-Index: 31
view all 7 authors...
Childhood trauma and neglect influence emotional development and increase the risk for and severity of mental illness. Women have a heightened susceptibility to the effects of early life stress (ELS) and are twice as likely as men to develop debilitating, stress-associated disorders later in life, such as major depressive disorder (MDD). Until now, mouse models of depression have been largely unsuccessful at replicating the diverse symptomatology of this disease and the sex bias in vulnerability...
17 CitationsSource
#1Haley L. Goodwill (Brown University)H-Index: 4
#2Gabriela Manzano-Nieves (Brown University)H-Index: 4
Last.Kevin G. Bath (Brown University)H-Index: 31
view all 11 authors...
Summary Poverty, displacement, and parental stress represent potent sources of early life stress (ELS). Stress disproportionately affects females, who are at increased risk for stress-related pathologies associated with cognitive impairment. Mechanisms underlying stress-associated cognitive impairment and enhanced risk of females remain unknown. Here, ELS is associated with impaired rule-reversal (RR) learning in females, but not males. Impaired performance was associated with decreased expressi...
5 CitationsSource
#1Gabriela Manzano-Nieves (Brown University)H-Index: 4
#2Mizan Gaillard (Brown University)H-Index: 1
Last.Kevin G. Bath (Brown University)H-Index: 31
view all 4 authors...
4 CitationsSource
#1Kevin G. Bath (Brown University)H-Index: 31
#2Arielle Schilit Nitenson (Brown University)H-Index: 3
Last.Gabriela Manzano-Nieves (Brown University)H-Index: 4
view all 8 authors...
Abstract Disruptions in early life care, including neglect, extreme poverty, and trauma, influence neural development and increase the risk for and severity of pathology. Significant sex disparities have been identified for affective pathology, with females having an increased risk of developing anxiety and depressive disorder. However, the effects of early life stress (ELS) on cognitive development have not been as well characterized, especially in reference to sex specific impacts of ELS on co...
17 CitationsSource
#1Kevin G. Bath (Brown University)H-Index: 31
#2Gabriela Manzano-Nieves (Brown University)H-Index: 4
Last.Haley L. Goodwill (Brown University)H-Index: 4
view all 3 authors...
Abstract Early life stress (ELS) increases the risk for later cognitive and emotional dysfunction. ELS is known to truncate neural development through effects on suppressing cell birth, increasing cell death, and altering neuronal morphology, effects that have been associated with behavioral profiles indicative of precocious maturation. However, how earlier silencing of growth drives accelerated behavioral maturation has remained puzzling. Here, we test the novel hypothesis that, ELS drives a sw...
52 CitationsSource
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