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Б С Шенкман
ImmunologyVon Willebrand factorBiochemistryMedicinePlatelet
73Publications
20H-index
2,447Citations
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Publications 68
Newest
#1Ivan BudnikH-Index: 7
#2Б С Шенкман (Sheba Medical Center)H-Index: 20
Last. Yulia Einav (HIT: Holon Institute of Technology)H-Index: 11
view all 4 authors...
: Trauma-induced coagulopathy (TIC) occurs commonly as a second event following severe injury. We evaluated the effects of fibrinogen, recombinant factor VIIa and factor XIII on blood clotting and fibrinolysis in an in-vitro TIC model. The TIC model included hemodilution, hyperfibrinolysis, acidosis and hypothermia. The extent of clot formation and fibrinolysis was evaluated using rotational thromboelastometry. Clot strength was increased following spiking the TIC blood with either 1.0 mg/ml fib...
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#1Ivan BudnikH-Index: 7
#2Б С Шенкман (Sheba Medical Center)H-Index: 20
Last. Yulia Einav (HIT: Holon Institute of Technology)H-Index: 11
view all 4 authors...
Purpose Coagulation abnormalities are common following major trauma. The aim of this study was to assess the improvement of trauma-induced coagulopathy (TIC) in an in vitro model.
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#1Ivan BudnikH-Index: 7
#2Б С Шенкман (Sheba Medical Center)H-Index: 20
Last. Yulia Einav (HIT: Holon Institute of Technology)H-Index: 11
view all 5 authors...
Abstract Thrombocytopenia (TCP) and Glanzmann thrombasthenia (GT) are typical platelet disorders characterized by mild to severe bleeding. This study aims to create in vitro models of TCP and GT and to correct the impaired clot formation by fibrinogen and coagulation factor XIII. The TCP model (mean platelet count, 16 × 10 9 L −1 ) was produced by differential centrifugation of normal blood followed by mixing plasma with packed cells. The GT model was created by treating normal blood with 50 μg/...
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#1Ivan BudnikH-Index: 7
#2Б С Шенкман (Sheba Medical Center)H-Index: 20
Last. Naphtali Savion (TAU: Tel Aviv University)H-Index: 39
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AbstractMechanisms of platelet activation are triggered by thrombin, adenosine diphosphate (ADP), epinephrine, thromboxane A2, and other soluble agonists which induce signaling via heterotrimeric Gαq, Gαi, and Gα12/13 proteins. We have undertaken a study addressing the contribution of these G proteins to platelet activation and clot formation in the presence of eptifibatide, thus excluding outside-in signaling provided by integrin αIIbβ3–fibrinogen engagement.Selective and combined activation of...
3 CitationsSource
#1Ivan Budnik (TAU: Tel Aviv University)H-Index: 7
#2Б С Шенкман (Sheba Medical Center)H-Index: 20
Last. Naphtali Savion (TAU: Tel Aviv University)H-Index: 39
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AbstractEffective platelet function requires formation of a physical link between fibrin(ogen), integrin αIIbβ3, and cytoplasmic actin filaments. We investigated the role of the Gαq, Gαi, and Gα12/13 families of heterotrimeric GTP-binding proteins (G proteins) in the assembly of a ligand–αIIbβ3–actin cytoskeleton complex. Selective and combined activation of the G proteins was achieved by using combinations of various platelet agonists and inhibitors. Formation and stability of fibrinogen–αIIbβ3...
2 CitationsSource
Between stages of Mohs micrographic surgery, the wound is dressed and the patient waits for the histopathological results. To investigate the efficacy of a hemostatic-anesthetic solution-impregnated gauze in decreasing bleeding between Mohs stages. Twenty patients were treated with a hemostatic-anesthetic solution composed of tranexamic acid, adrenaline, and lidocaine (TAL), and 20 others were treated with a saline solution for control. At the second Mohs stage, size measurements of the blood st...
2 Citations
#1Rakefet Sidlik (Sheba Medical Center)H-Index: 1
#2Tzipora Strauss (TAU: Tel Aviv University)H-Index: 8
Last. Gili Kenet (Sheba Medical Center)H-Index: 31
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Background The fibrinolytic system in newborns is immature and probably impaired. The aim of this study was to prospectively evaluate functional fibrinolytic capacity of newborn's cord blood using a new thromboelastometry (rotational thromboelastogram, ROTEM®) test. Methods Infants born at Sheba Medical Center were studied prospectively. Cord blood was obtained immediately after clumping, and ROTEM parameters were assessed applying non-activated TEM (NATEM) assay with increasing concentration of...
7 CitationsSource
#1Tami Livnat (Sheba Medical Center)H-Index: 12
#2Б С Шенкман (Sheba Medical Center)H-Index: 20
Last. Ophira Salomon (Sheba Medical Center)H-Index: 26
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Abstract The phenotype of bleeding in patients with severe FXI deficiency is unpredictable and unlike other bleeding disorders, it is not directly correlated with levels of FXI. In this study we analyzed whether the global coagulation assays can serve as a clinical tool in predicting bleeding tendency in patients with severe FXI deficiency undergoing surgery, taking into account the large inter-individual variability of FXI levels and genotypes. Thrombin generation (TG) was measured in 39 platel...
15 CitationsSource
#1Б С Шенкман (Sheba Medical Center)H-Index: 20
#2Yulia Einav (HIT: Holon Institute of Technology)H-Index: 11
Last. Uri Martinowitz (Sheba Medical Center)H-Index: 41
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SummaryIntroduction Bleeding symptoms in severe thrombocytopenia range from mild to severe. The aim of this in vitro study was to improve blood clotting and protect against fibrinolysis in reconstituted severe thrombocytopenia blood. Methods Thrombocytopenia [(16 ± 4) × 106/mL] was created by high-speed centrifugation of normal blood with subsequent mixing plasma with packed cells. The blood samples were subjected to clotting by CaCl2 and tissue factor and to fibrinolysis by the addition of tiss...
7 CitationsSource
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