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Lorenzo Alibardi
University of Bologna
81Publications
25H-index
2,070Citations
Publications 81
Newest
Published on Jun 1, 2016in Tissue & Cell 1.44
Lorenzo Alibardi27
Estimated H-index: 27
(University of Bologna)
Abstract After limb amputation in lizards no regeneration occurs following massive inflammatory reaction. Light immunocytochemistry for CD68 and ultrastructural observations show that numerous macrophages persist for over 18 days post-amputation in the limb and fibroblasts producing high levels of collagen are present underneath a differentiating wound epidermis. Injections of 5BrdU for 1 week in normal lizards followed by a 4 weeks chase period indicate that most Long Retention Cells are presen...
12 Citations Source Cite
Published on Jun 1, 2016in Journal of Structural Biology 3.43
Matteo Calvaresi20
Estimated H-index: 20
(University of Bologna),
Leopold Eckhart29
Estimated H-index: 29
(Medical University of Vienna),
Lorenzo Alibardi25
Estimated H-index: 25
(University of Bologna)
Abstract The hard corneous material of avian and reptilian scales, claws, beak and feathers is mainly derived from the presence of proteins formerly known as beta-keratins but now termed Corneous beta-proteins of sauropsids to distinguish them from keratins, which are members of the intermediate filament protein family. The modeling of the conserved 34 amino acid residues long central beta-sheet region of Corneous beta-proteins using an ab initio protein folding and structure prediction algorith...
16 Citations Source Cite
Lorenzo Alibardi25
Estimated H-index: 25
The adaptation of the epidermis in amniote vertebrates to life on land took place by a drastic change from an embryonic epidermis made of two-four periderm layers to a terrestrial-proof epidermis. This transition occurred by the increase in types and number of specialized corneous proteins coded by genes of the Epidermal Differentiation Complex. The prevalent types of corneous proteins produced in the reptilian epidermis contain a beta-sheet region of high amino acid homology which allows their ...
3 Citations Source Cite
Lorenzo Alibardi25
Estimated H-index: 25
(University of Bologna)
Abstract The present review summarizes biochemical, histochemical and immunocytochemical aspects of the process of tissue regeneration in lizards, non-mammalian amniotes with high regenerative power. The amputated tail initially mobilizes the glycogen and lipid reserves during wound healing. In the following stage of formation of the regenerative blastema tissue remodeling produces a typical embryonic tissue, initially increasing the amount of water and glycosaminoglycans such as jaluronate, whi...
49 Citations Source Cite
Published on Dec 1, 2013in Journal of Morphology 1.71
Lorenzo Alibardi25
Estimated H-index: 25
(University of Bologna)
Knowledge of beta-protein (beta-keratin) sequences in Anolis carolinensis facilitates the localization of specific sites in the skin of this lizard. The epidermal distribution of two new beta-proteins (beta-keratins), HgGC8 and HgG13, has been analyzed by Western blotting, light and ultrastructural immunocytochemistry. HgGC8 includes 16 kDa members of the glycine-cysteine medium-rich subfamily and is mainly expressed in the beta-layer of adhesive setae but not in the setae. HgGC8 is absent in ot...
6 Citations Source Cite
Published on Oct 1, 2013in Acta Histochemica 1.65
Lorenzo Alibardi25
Estimated H-index: 25
(University of Bologna),
Masaru Tsuchiya3
Estimated H-index: 3
(Kao Corporation)
+ 1 AuthorsBernd Nöcker2
Estimated H-index: 2
Abstract Unlike the superficial part of the corneous layer of the epidermis ( Stratum corneum ) where desmosomes are degraded and corneocytes flake away, the trichocytes in the hair remain attached to each other after cornification. The permanence and fine localization of cell junctions, in particular of desmosomal proteins in the cornifying and mature human hair, is not known. The present electron microscope immunolocalization study indicates that two protein markers for desmosomes such as desm...
2 Citations Source Cite
Published on Sep 1, 2013in Micron 1.73
Lorenzo Alibardi25
Estimated H-index: 25
(University of Bologna)
Abstract The epidermis of soft-shelled and hard-shelled turtles has been compared to determine the origin of the different cornification. Immunolocalization of acidic alpha-keratin (AK2) of 45–50 kDa in tonofilaments of the epidermis in Apalone spinifera and absence in the corneous layer where desquamating corneocytes are present supports the biochemical data. Corneocytes shows a weak to absent immunolabeling for beta-proteins (formerly beta-keratins) of 14–16 kDa while sparse immunolabeled corn...
6 Citations Source Cite
Published on Aug 1, 2013in Tissue & Cell 1.44
Lorenzo Alibardi25
Estimated H-index: 25
(University of Bologna)
Abstract The previous identification of 21 proteins in the digital setae transcriptome of Gekko gecko , 2 alpha-keratins of 52–53 kDa and 19 beta-proteins (beta-keratins) of 10–21 kDa, has indicated that most of setal corneous proteins are cysteine-rich. The production of specific antibodies for two of the main beta-protein subfamilies expressed in gecko setae has allowed the ultrastructural localization of two beta-proteins indicated as Ge-cprp-9 (cysteine-rich) and Ge-gprp-6 (glycine-rich). On...
12 Citations Source Cite
Published on Aug 1, 2013in Tissue & Cell 1.44
Lorenzo Alibardi25
Estimated H-index: 25
(University of Bologna)
Abstract The presence of beta-proteins containing a core-box region in specific regions of reptilian epidermis has been studied by immunological methods. Alpha-keratins are detected by the antibody AK2 that recognizes a sequence toward the C-terminal of acidic alpha-keratins of 48–52 kDa. Beta-proteins are recognized by an antibody directed to the core-box region specific for these proteins of 18–37 kDa. The AK2 antibody labels with variable intensity alpha-keratin bundles in basal and suprabasa...
3 Citations Source Cite
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