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Lihua Chen
Jiangxi University of Traditional Chinese Medicine
PharmacokineticsChemistryTransdermalChromatographyPharmacology
22Publications
3H-index
60Citations
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Publications 18
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#1Yongmei GuanH-Index: 4
#2Jia Liu (JUTCM: Jiangxi University of Traditional Chinese Medicine)
Last. Lu WuH-Index: 1
view all 8 authors...
In order to increase the stability and solubility of essential oil in Jieyu Anshen Formula, this study was to prepare the essential oil into liposomes. In this experiment, the method for the determination of encapsulation efficiency of liposomes was established by ultraviolet spectrophotometer and dextran gel column. The encapsulation efficiency and particle size of liposomes were used as evaluation indexes for single factor investigation and Box-Behnken design-response surface method was used t...
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#1Lihua Chen (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 3
#2Tian-Nyu Shi (JUTCM: Jiangxi University of Traditional Chinese Medicine)
Last. Yongmei Guan (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 4
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Commonly used dosage forms of fermented Cordyceps powder products are capsules and tablets. The hygroscopicity of the powder,as one of the important parameters in the tableting process,has important effects on the tabletting process of the tablets. How to improve the hygroscopicity of powder is of great significance for the development of new composite particles. Therefore,particle design technology was used in this study to prepare composite particle powder,and its hygroscopicity was compared w...
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#1Lihua Chen (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 3
#2Yao Wu (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 1
Last. Ming YangH-Index: 1
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Fermented Cordyceps sinensis, the succedaneum of Cordyceps sinensis which is extracted and separated from Cordyceps sinensis by artificial fermentation, is commonly used in eastern Asia in clinical treatments due to its health benefit. In this paper, a new strategy for differentiating and comprehensively evaluating the quality of products of fermented Cordyceps sinensis has been established, based on high-performance liquid chromatography (HPLC) fingerprint analysis combined with similar analysi...
2 CitationsSource
The aim of this study was to prepare triptolide and ferulic acid ethosomes gel, investigate its transdermal permeation, and compare the results with ordinary gel and cream. Improved Franz diffusion cell method was used in the transdermal delivery experiment with rat abdominal skin as in vitro model. The receptor fluid at different time points was collected; ferulic acid concentration was determined by high performance liquid chromatography (HPLC) and triptolide concentration was determined by li...
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Semen Strychni has been extensively used as a Chinese herb, but its therapeutic window is narrowed by the strong toxicity of the compound, which limits its effectiveness. Radix Paeoniae Alba has been reported to reduce the toxic effects and increase the therapeutic effects of Semen Strychni, but the underlying mechanism remains unknown. This research aimed to explore the mechanism through which P-glycoprotein (P-gp) is modulated by Semen Strychni combined with Radix Paeoniae Alba in vitro. An MT...
1 CitationsSource
#1Lihua Chen (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 3
#2Xue-Ping Lu (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 1
Last. Wei-feng Zhu (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 4
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Fritillaria thunbergii Miq. has been widely used in traditional Chinese medicine for its expectorant, antitussive, antiinflammatory and analgesic properties. Moreover, modern pharmacological studies have demonstrated that F. thunbergii Miq. has efficacy in the treatment of leukemia and cancers of the liver and cervix. Although the alkaloid, peimine, is largely responsible for these pharmacological effects, it has very low oral bioavailability. The aim of this study was to investigate the intesti...
12 CitationsSource
#1Lihua Chen (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 3
#2Dongxun Li (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 1
Last. Hongning Liu (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 4
view all 8 authors...
Peimisine, the common ingredient of “zhebeimu” groups and “chuanbeimu” groups, is responsible for the expectorant and cough relieving effects. The aim of this study was to investigate the pharmacokinetics, tissue distribution and excretion of peimisine in male and female SD (Sprague-Dawley) rats by a rapid and sensitive LC-MS/MS (liquid chromatography-tandem mass spectrometry) method used carbamazepine as the internal standard after oral administration, carbamazepine was stated as an IS. The res...
2 CitationsSource
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