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Keji Chen
4Publications
3H-index
23Citations
Publications 4
Newest
Published on Mar 18, 2019in Oxidative Medicine and Cellular Longevity 4.87
Jinfan Tian3
Estimated H-index: 3
(Capital Medical University),
Mohammad Sharif Popal (Capital Medical University)+ 4 AuthorsYue Liu4
Estimated H-index: 4
Background. There is a crosstalk between endoplasmic reticulum stress (ERS) and autophagy, and autophagy could attenuate endoplasmic reticulum stress-mediated apoptosis. Ginkgo biloba leaf extract (GBE) exerts vascular protection functions. The purpose of the present study is to investigate the role of autophagy in diabetic atherosclerosis (AS) and the effect of GBE on autophagy and ERS. Methods. Network pharmacology was utilized to predict the targets and pathways of the active chemical compoun...
Published on Jan 1, 2018in Oxidative Medicine and Cellular Longevity 4.87
Jinfan Tian3
Estimated H-index: 3
(Capital Medical University),
Yanfei Liu3
Estimated H-index: 3
(Beijing University of Chinese Medicine)
+ 2 AuthorsShuzheng Lyu3
Estimated H-index: 3
(Capital Medical University)
Diabetes was induced in high-fat diet-fed ApoE−/− mice via administration of low-dose streptozotocin (STZ) for five days. Mice were then treated with GBE (200 or 400 mg/kg) by gastric gavage daily for 12 weeks. Mice in the untreated diabetic group received saline instead, and nondiabetic C57BL/6J mice served as controls. Collagen І and ІІІ mRNA expression was measured by real-time PCR. TNF-α, IL-1β mRNA levels, and NF-κB expression were determined to analyze intramyocardial inflammation. Hallmar...
Published on Jan 1, 2017in Oxidative Medicine and Cellular Longevity 4.87
Jinfan Tian3
Estimated H-index: 3
,
Yingke Zhao2
Estimated H-index: 2
+ 3 AuthorsShuzheng Lyu3
Estimated H-index: 3
Diabetic cardiomyopathy is one of the major complications among patients with diabetes mellitus. Diabetic cardiomyopathy (DCM) is featured by left ventricular hypertrophy, myocardial fibrosis, and damaged left ventricular systolic and diastolic functions. The pathophysiological mechanisms include metabolic-altered substrate metabolism, dysfunction of microvascular, renin-angiotensin-aldosterone system (RAAS) activation, oxidative stress, cardiomyocyte apoptosis, mitochondrial dysfunction, and im...
Published on Jan 1, 2016in Oxidative Medicine and Cellular Longevity 4.87
Yingke Zhao2
Estimated H-index: 2
,
Yue Liu1
Estimated H-index: 1
,
Keji Chen3
Estimated H-index: 3
Tetramethylpyrazine, a natural compound from Ligusticum wallichii (Chuan Xiong), has been extensively used in China for cardiovascular and cerebrovascular diseases for about 40 years. Because of its effectiveness in multisystems, especially in cardiovascular, its pharmacological action, clinical application, and the structural modification have attracted broad attention. In this paper its mechanisms of action, the clinical status, and synthetic derivatives will be reviewed briefly.
1