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Bopanna I. Kalappa
University of Pittsburgh
13Publications
9H-index
257Citations
Publications 13
Newest
Published on Jan 1, 2017
Bopanna I. Kalappa9
Estimated H-index: 9
(University of Pittsburgh),
Thanos Tzounopoulos14
Estimated H-index: 14
(University of Pittsburgh)
Abstract Synaptically released zinc inhibits baseline excitatory neurotransmission; however, the role of this neuromodulator on short-term plasticity during different levels of synaptic activity remains largely unknown. This lack of knowledge prevents our understanding of information transfer across zinc-releasing synapses, including 50% of excitatory synapses in cortical areas. We used in vitro electrophysiology in mouse brain slices and discovered that the effects of zinc on excitatory postsyn...
Published on Aug 10, 2016in The Journal of Neuroscience 6.07
Ankur Joshi2
Estimated H-index: 2
(University of Pittsburgh),
Bopanna I. Kalappa9
Estimated H-index: 9
(University of Pittsburgh)
+ 1 AuthorsThanos Tzounopoulos14
Estimated H-index: 14
(University of Pittsburgh)
The neuromodulator acetylcholine (ACh) is crucial for several cognitive functions, such as perception, attention, and learning and memory. Whereas, in most cases, the cellular circuits or the specific neurons via which ACh exerts its cognitive effects remain unknown, it is known that auditory cortex (AC) neurons projecting from layer 5B (L5B) to the inferior colliculus, corticocollicular neurons, are required for cholinergic-mediated relearning of sound localization after occlusion of one ear. T...
Bopanna I. Kalappa9
Estimated H-index: 9
(University of Pittsburgh),
Charles T. Anderson13
Estimated H-index: 13
(University of Pittsburgh)
+ 2 AuthorsThanos Tzounopoulos14
Estimated H-index: 14
(University of Pittsburgh)
The vast amount of fast excitatory neurotransmission in the mammalian central nervous system is mediated by AMPA-subtype glutamate receptors (AMPARs). As a result, AMPAR-mediated synaptic transmission is implicated in nearly all aspects of brain development, function, and plasticity. Despite the central role of AMPARs in neurobiology, the fine-tuning of synaptic AMPA responses by endogenous modulators remains poorly understood. Here we provide evidence that endogenous zinc, released by single pr...
Published on Aug 27, 2015in eLife 7.55
Shuang Li4
Estimated H-index: 4
(University of Pittsburgh),
Bopanna I. Kalappa9
Estimated H-index: 9
(University of Pittsburgh),
Thanos Tzounopoulos14
Estimated H-index: 14
(University of Pittsburgh)
Tinnitus is often described as ‘ringing in the ears’. Though the phantom sounds, which are heard in the absence of any genuine external noise, can take a variety of forms including buzzing, whistling, or humming. While training the brain to pay less attention to these internally generated sounds can sometimes reduce the impact of tinnitus, many people find that the disorder reduces their quality of life significantly. One of the main causes of tinnitus is prolonged or repeated exposure to excess...
Published on Jun 10, 2015in The Journal of Neuroscience 6.07
Bopanna I. Kalappa9
Estimated H-index: 9
(University of Pittsburgh),
Heun Soh6
Estimated H-index: 6
(UConn: University of Connecticut)
+ 4 AuthorsThanos Tzounopoulos14
Estimated H-index: 14
(University of Pittsburgh)
Voltage-gated Kv7 (KCNQ) channels are voltage-dependent potassium channels that are activated at resting membrane potentials and therefore provide a powerful brake on neuronal excitability. Genetic or experience-dependent reduction of KCNQ2/3 channel activity is linked with disorders that are characterized by neuronal hyperexcitability, such as epilepsy and tinnitus. Retigabine, a small molecule that activates KCNQ2–5 channels by shifting their voltage-dependent opening to more negative voltages...
Published on Jan 1, 2015
Rui Cai10
Estimated H-index: 10
,
Bopanna I. Kalappa9
Estimated H-index: 9
+ 2 AuthorsM Donald
Published on Jan 1, 2015
George A. Spirou20
Estimated H-index: 20
,
Albert S. Berrebi19
Estimated H-index: 19
+ 9 AuthorsMalcolm N. Semple22
Estimated H-index: 22
Published on Nov 15, 2014in The Journal of Physiology
Bopanna I. Kalappa9
Estimated H-index: 9
(Southern Illinois University School of Medicine),
Thomas J. Brozoski18
Estimated H-index: 18
(Southern Illinois University School of Medicine)
+ 1 AuthorsDonald M. Caspary48
Estimated H-index: 48
(Southern Illinois University School of Medicine)
Key points Medial geniculate body (MGB) single units recorded from sound-exposed animals with behavioural evidence of tinnitus exhibits enhanced spontaneous firing and burst properties. MGB units in tinnitus animals exhibit increased rate-level function slope when driven by broadband noise and tones at the unit's characteristic frequency. Elevated patterns of neuronal activity and altered bursting showed a significant positive correlation with animals’ tinnitus scores. Tinnitus is an auditory pe...
Published on Jan 15, 2014in Journal of Neurophysiology 2.61
Rui Cai10
Estimated H-index: 10
(Southern Illinois University School of Medicine),
Bopanna I. Kalappa9
Estimated H-index: 9
(Southern Illinois University School of Medicine)
+ 2 AuthorsDonald M. Caspary48
Estimated H-index: 48
(Southern Illinois University School of Medicine)
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central auditory system. Sensory thalamic structures show high levels of non-desensitizing extrasynaptic GABAA receptors (GABAARs) and a reduction in the redundancy of coded information. The present study compared the inhibitory potency of GABA acting at GABAARs between the inferior colliculus (IC) and the medial geniculate body (MGB) using quantitative in vivo, in vitro, and ex vivo experimental approaches. In vivo s...
Published on Oct 1, 2013in European Journal of Pharmacology 3.17
Bopanna I. Kalappa9
Estimated H-index: 9
(Southern Illinois University School of Medicine),
Victor V. Uteshev15
Estimated H-index: 15
(University of North Texas Health Science Center)
PNU-120596 (1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea), a Type-II positive allosteric modulator of α7 nicotinic acetylcholine receptors inhibits α7 desensitization and robustly prolongs openings of α7 channels. However, these effects may render α7 channels more accessible to positively charged molecules and thus, more susceptible to voltage-dependent open-channel-block-like inhibition. To test this hypothesis, choline chloride (i.e., choline), a selective endogenous α7 agoni...
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