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Bopanna I. Kalappa
University of Pittsburgh
14Publications
9H-index
281Citations
Publications 15
Newest
#1Bopanna I. Kalappa (University of Pittsburgh)H-Index: 9
#2Thanos Tzounopoulos (University of Pittsburgh)H-Index: 15
Abstract Synaptically released zinc inhibits baseline excitatory neurotransmission; however, the role of this neuromodulator on short-term plasticity during different levels of synaptic activity remains largely unknown. This lack of knowledge prevents our understanding of information transfer across zinc-releasing synapses, including 50% of excitatory synapses in cortical areas. We used in vitro electrophysiology in mouse brain slices and discovered that the effects of zinc on excitatory postsyn...
6 CitationsSource
#1Ankur Joshi (University of Pittsburgh)H-Index: 2
#2Bopanna I. Kalappa (University of Pittsburgh)H-Index: 9
Last.Thanos Tzounopoulos (University of Pittsburgh)H-Index: 15
view all 4 authors...
The neuromodulator acetylcholine (ACh) is crucial for several cognitive functions, such as perception, attention, and learning and memory. Whereas, in most cases, the cellular circuits or the specific neurons via which ACh exerts its cognitive effects remain unknown, it is known that auditory cortex (AC) neurons projecting from layer 5B (L5B) to the inferior colliculus, corticocollicular neurons, are required for cholinergic-mediated relearning of sound localization after occlusion of one ear. T...
11 CitationsSource
#1Bopanna I. Kalappa (University of Pittsburgh)H-Index: 9
#2Charles T. Anderson (University of Pittsburgh)H-Index: 13
Last.Thanos Tzounopoulos (University of Pittsburgh)H-Index: 15
view all 5 authors...
The vast amount of fast excitatory neurotransmission in the mammalian central nervous system is mediated by AMPA-subtype glutamate receptors (AMPARs). As a result, AMPAR-mediated synaptic transmission is implicated in nearly all aspects of brain development, function, and plasticity. Despite the central role of AMPARs in neurobiology, the fine-tuning of synaptic AMPA responses by endogenous modulators remains poorly understood. Here we provide evidence that endogenous zinc, released by single pr...
32 CitationsSource
#1Shuang Li (University of Pittsburgh)H-Index: 6
#2Bopanna I. Kalappa (University of Pittsburgh)H-Index: 9
Last.Thanos Tzounopoulos (University of Pittsburgh)H-Index: 15
view all 3 authors...
Tinnitus is often described as ‘ringing in the ears’. Though the phantom sounds, which are heard in the absence of any genuine external noise, can take a variety of forms including buzzing, whistling, or humming. While training the brain to pay less attention to these internally generated sounds can sometimes reduce the impact of tinnitus, many people find that the disorder reduces their quality of life significantly. One of the main causes of tinnitus is prolonged or repeated exposure to excess...
30 CitationsSource
#1Shuang Li (University of Pittsburgh)H-Index: 6
#2Bopanna I. Kalappa (University of Pittsburgh)H-Index: 9
Last.Thanos Tzounopoulos (University of Pittsburgh)H-Index: 15
view all 3 authors...
Source
#1Bopanna I. Kalappa (University of Pittsburgh)H-Index: 9
#2Heun Soh (UConn: University of Connecticut)H-Index: 5
Last.Thanos Tzounopoulos (University of Pittsburgh)H-Index: 15
view all 7 authors...
Voltage-gated Kv7 (KCNQ) channels are voltage-dependent potassium channels that are activated at resting membrane potentials and therefore provide a powerful brake on neuronal excitability. Genetic or experience-dependent reduction of KCNQ2/3 channel activity is linked with disorders that are characterized by neuronal hyperexcitability, such as epilepsy and tinnitus. Retigabine, a small molecule that activates KCNQ2–5 channels by shifting their voltage-dependent opening to more negative voltages...
35 CitationsSource
#1Rui CaiH-Index: 10
#2Bopanna I. KalappaH-Index: 9
view all 5 authors...
#1George A. SpirouH-Index: 20
#2Albert S. BerrebiH-Index: 20
Last.Malcolm N. SempleH-Index: 28
view all 12 authors...
#1Bopanna I. Kalappa (Southern Illinois University School of Medicine)H-Index: 9
#2Thomas J. Brozoski (Southern Illinois University School of Medicine)H-Index: 18
Last.Donald M. Caspary (Southern Illinois University School of Medicine)H-Index: 49
view all 4 authors...
Key points Medial geniculate body (MGB) single units recorded from sound-exposed animals with behavioural evidence of tinnitus exhibits enhanced spontaneous firing and burst properties. MGB units in tinnitus animals exhibit increased rate-level function slope when driven by broadband noise and tones at the unit's characteristic frequency. Elevated patterns of neuronal activity and altered bursting showed a significant positive correlation with animals’ tinnitus scores. Tinnitus is an auditory pe...
57 CitationsSource
#1Rui Cai (Southern Illinois University School of Medicine)H-Index: 10
#2Bopanna I. Kalappa (Southern Illinois University School of Medicine)H-Index: 9
Last.Donald M. Caspary (Southern Illinois University School of Medicine)H-Index: 49
view all 5 authors...
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central auditory system. Sensory thalamic structures show high levels of non-desensitizing extrasynaptic GABAA receptors (GABAARs) and a reduction in the redundancy of coded information. The present study compared the inhibitory potency of GABA acting at GABAARs between the inferior colliculus (IC) and the medial geniculate body (MGB) using quantitative in vivo, in vitro, and ex vivo experimental approaches. In vivo s...
8 CitationsSource
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