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Meenakshi Ravichandran
École Polytechnique Fédérale de Lausanne
3Publications
2H-index
40Citations
Publications 3
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#1Meenakshi Ravichandran (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 2
#2Steffen Priebe (Leibniz Association)H-Index: 16
Last.Michael Ristow (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 50
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Summary Whether and how regulation of genes and pathways contributes to physiological aging is topic of intense scientific debate. By performing an RNA expression-based screen for genes downregulated during aging of three different species, we identified glycine-C-acetyltransferase (GCAT, EC 2.3.1.29). Impairing gcat expression promotes the lifespan of C. elegans by interfering with threonine catabolism to promote methylglyoxal (MGO; CAS 78-98-8) formation in an amine oxidase-dependent manner. M...
#1Meenakshi Ravichandran (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 2
#2Gerald GrandlH-Index: 4
Last.Michael Ristow (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 50
view all 3 authors...
The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.
Ageing has been defined as a global decline in physiological function depending on both environmental and genetic factors. Here we identify gene transcripts that are similarly regulated during physiological ageing in nematodes, zebrafish and mice. We observe the strongest extension of lifespan when impairing expression of the branched-chain amino acid transferase-1 (bcat-1) gene in C. elegans, which leads to excessive levels of branched-chain amino acids (BCAAs). We further show that BCAAs reduc...
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