Meenakshi Ravichandran
École Polytechnique Fédérale de Lausanne
3Publications
2H-index
37Citations
Publications 3
Newest
Published on Apr 1, 2018in Cell Metabolism 20.57
Meenakshi Ravichandran2
Estimated H-index: 2
(École Polytechnique Fédérale de Lausanne),
Steffen Priebe16
Estimated H-index: 16
(Leibniz Association)
+ 7 AuthorsMichael Ristow47
Estimated H-index: 47
(École Polytechnique Fédérale de Lausanne)
Summary Whether and how regulation of genes and pathways contributes to physiological aging is topic of intense scientific debate. By performing an RNA expression-based screen for genes downregulated during aging of three different species, we identified glycine-C-acetyltransferase (GCAT, EC 2.3.1.29). Impairing gcat expression promotes the lifespan of C. elegans by interfering with threonine catabolism to promote methylglyoxal (MGO; CAS 78-98-8) formation in an amine oxidase-dependent manner. M...
5 Citations Source Cite
Published on Oct 1, 2017in Cell Metabolism 20.57
Meenakshi Ravichandran2
Estimated H-index: 2
(École Polytechnique Fédérale de Lausanne),
Gerald Grandl4
Estimated H-index: 4
,
Michael Ristow47
Estimated H-index: 47
(École Polytechnique Fédérale de Lausanne)
The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.
1 Citations Source Cite
Published on Dec 1, 2015in Nature Communications 12.35
Johannes Mansfeld6
Estimated H-index: 6
,
Nadine Urban3
Estimated H-index: 3
+ 21 AuthorsSebastian Schmeisser9
Estimated H-index: 9
Ageing has been defined as a global decline in physiological function depending on both environmental and genetic factors. Here we identify gene transcripts that are similarly regulated during physiological ageing in nematodes, zebrafish and mice. We observe the strongest extension of lifespan when impairing expression of the branched-chain amino acid transferase-1 (bcat-1) gene in C. elegans, which leads to excessive levels of branched-chain amino acids (BCAAs). We further show that BCAAs reduc...
31 Citations Source Cite
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