Huixuan Zhou
Shanghai Jiao Tong University
Publications 3
#1Yan Wang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Quanhong Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 9
Last.Ai-Zhong Wang (SJTU: Shanghai Jiao Tong University)H-Index: 3
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Background and Purpose Exaggerated hypotension following administration of propofol is strongly predicted in patients with hypertension. Increased PKCs play a crucial role in regulating vascular tone. We studied whether propofol induces vasodilation by inhibiting increased PKC activity in spontaneously hypertensive rats (SHRs) and, if so, whether contractile Ca2+ sensitization pathways and filamentous–globular (F/G) actin dynamics were involved. Experimental Approach Rings of thoracic aorta, den...
#1Huixuan ZhouH-Index: 1
#2Yan WangH-Index: 1
Last.Li WangH-Index: 5
view all 7 authors...
Background/Aims: Phorbol myristate acetate (PMA) exerts a pleiotropic effect on the growth and differentiation of various cells. Protein kinase Cs (PKCs) plays a
#1Yan WangH-Index: 1
#2Huixuan ZhouH-Index: 1
Last.Li WangH-Index: 5
view all 6 authors...
Abstract Protein kinase C (PKC) isoforms improve endothelial nitric oxide synthase activity and contractile Ca sensitivity in blood vessels. These actions may have opposite effects on propofol-induced vasodilation. This study examines the hypothesis that propofol induces relaxation by enhancing the PKC-mediated nitric oxide synthesis in endothelium and/or inhibiting the PKC-regulated Ca sensitivity in vascular smooth muscle (VSM). Propofol (1-100 μM) induced greater relaxation in endothelium-int...