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Nikolaos Perakakis
Beth Israel Deaconess Medical Center
63Publications
9H-index
311Citations
Publications 67
Newest
#1So-Young Kwak (KU: Korea University)H-Index: 1
#2InHyeok Chung (KU: Korea University)
Last.Oh Yoen Kim (Dong-a University)H-Index: 29
view all 17 authors...
Abstract Background Based on the metabolic effect of exogenous ATPase inhibitory factor 1 (IF1) on glucose metabolism, we tested whether IF1 treatment is effective in ameliorating weight gain and whether its effects are sex specific. Methods HFD-fed C57BL/6 mice were treated with IF1 (5 mg/kg body weight, injected intraperitoneally). The underlying mechanisms of effect of IF1 on body weight were investigated in vitro and in vivo. Associations between genotypes of IF1 and obesity and relevant phe...
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#1Nikolaos Perakakis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 9
#2Alexander Kokkinos (UoA: National and Kapodistrian University of Athens)H-Index: 15
Last.Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 106
view all 8 authors...
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#1Natia Peradze (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 2
#2Olivia M. Farr (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 20
Last.Christos S. Mantzoros (Harvard University)H-Index: 106
view all 6 authors...
Long-term treatment with up to 1.8 mg liraglutide improves cardiovascular and all-cause mortality in patients with type 2 diabetes at high risk for cardiovascular disease (CVD) and is currently under investigation in subjects without diabetes. Aim of our study was to investigate whether high dose (3 mg) short-term (5 weeks) treatment with liraglutide in obese patients with no overt type 2 diabetes affects metabolites, lipid and lipoprotein profile and components of activin–follistatin axis in ca...
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#1Nikolaos Perakakis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 9
#2Alexander Kokkinos (UoA: National and Kapodistrian University of Athens)H-Index: 15
Last.Christos S. Mantzoros (Harvard University)H-Index: 106
view all 9 authors...
Abstract Aims Bariatric surgery leads to profound and sustainable weight loss. Gastrointestinal hormones are involved in energy and glucose homeostasis, thus postoperative changes of their circulating levels may be mediating future weight loss. To investigate how the circulating concentrations of gastrointestinal hormones change in response to the most common types of bariatric operation and whether these changes can predict future weight loss. Materials and Methods We measured circulating GLP-1...
1 CitationsSource
#1Nikolaos Perakakis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 9
#2Stergios A. Polyzos (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 32
Last.Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 106
view all 7 authors...
Abstract Background Non-alcoholic fatty liver disease (NAFLD) affects 25–30% of the general population and is characterized by the presence of non-alcoholic fatty liver (NAFL) that can progress to non-alcoholic steatohepatitis (NASH), liver fibrosis and cirrhosis leading to hepatocellular carcinoma. To date, liver biopsy is the gold standard for the diagnosis of NASH and for staging liver fibrosis. This study aimed to train models for the non-invasive diagnosis of NASH and liver fibrosis based o...
1 CitationsSource
#1Stergios A. Polyzos (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 32
#2Nikolaos Perakakis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 9
Last.Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 106
view all 8 authors...
Source
#1Laura Potasso (University of Freiburg)
#2Nikolaos Perakakis (University of Freiburg)H-Index: 9
Last.Katharina Laubner (University of Freiburg)H-Index: 7
view all 9 authors...
Background The single nucleotide polymorphism in TCF7L2 rs7903146 is associated with an increased risk of type 2 diabetes mellitus and gestational diabetes mellitus. Mechanisms by which this mutation acts, and its impact on the clinical course of the diseases remain unclear. Here we investigated the clinical impact of the T risk allele in women with gestational diabetes mellitus. Methods We genotyped the C/T polymorphism in 164 Caucasian women with GDM (German n=114; Greek n=50). The impact of t...
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#1Niki Katsiki (BIDMC: Beth Israel Deaconess Medical Center)
#2Nikolaos Perakakis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 9
Last.Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 106
view all 3 authors...
Source
#1Eleni Pilitsi (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 1
#2Natia Peradze (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 2
Last.Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 106
view all 4 authors...
Abstract Objective It remains unclear whether food deprivation induces changes in components of the GH/IGF-1/IGFBPs axis and if yes, which ones are mediated by leptin, an adipocyte secreted hormone regulating neuroendocrine response to energy deprivation in animals and humans. We aimed to investigate components of the axis that have not been studied to date, i.e. IGF-binding proteins (IGFBPs) and related proteases (total and intact IGFBP 3 and IGFBP 4, total IGFBP 5, PAPPA, PAPPA2 and Stanniocal...
Source
#1Stergios A. Polyzos (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 32
#2Nikolaos Perakakis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 9
Last.Christos S. Mantzoros (Harvard University)H-Index: 106
view all 3 authors...
Abstract Lipodystrophy is a group of clinically heterogeneous, inherited or acquired, disorders characterized by complete or partial absence of subcutaneous adipose tissue that may occur simultaneously with the pathological, ectopic, accumulation of fat in other regions of the body, including the liver. Fatty liver adds significantly to hepatic and extra-hepatic morbidity in patients with lipodystrophy. Lipodystrophy is strongly associated with severe insulin resistance and related comorbidities...
3 CitationsSource
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