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Nikolaos Perakakis
Beth Israel Deaconess Medical Center
EndocrinologyInsulinDiabetes mellitusMedicineBiology
68Publications
10H-index
525Citations
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Publications 68
Newest
#1Nikolaos Perakakis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 10
#2Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 108
Source
#1SoYoung Kwak (KU: Korea University)H-Index: 1
#1So Young Kwak (KU: Korea University)H-Index: 4
Last. Oh Yoen Kim (Dong-a University)H-Index: 14
view all 17 authors...
Abstract Background Based on the metabolic effect of exogenous ATPase inhibitory factor 1 (IF1) on glucose metabolism, we tested whether IF1 treatment is effective in ameliorating weight gain and whether its effects are sex specific. Methods HFD-fed C57BL/6 mice were treated with IF1 (5 mg/kg body weight, injected intraperitoneally). The underlying mechanisms of effect of IF1 on body weight were investigated in vitro and in vivo. Associations between genotypes of IF1 and obesity and relevant phe...
Source
#1Stergios A. Polyzos (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 34
#2Nikolaos Perakakis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 10
Last. Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 108
view all 8 authors...
AIMS: To investigate circulating levels and liver gene expression of 3 hormonal pathways associated with obesity, insulin resistance, and inflammation to identify leads towards potential diagnostic markers and therapeutic targets in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: We compared circulating levels of (1) proglucagon-derived hormones (glucagon-like peptide [GLP]-1, GLP-2, glicentin, oxyntomodulin, glucagon, major proglucagon fragment [MPGF]), (2) follistatins-activin...
2 CitationsSource
#1Nikolaos Perakakis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 10
#2Alexander Kokkinos (UoA: National and Kapodistrian University of Athens)H-Index: 16
Last. Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 108
view all 8 authors...
OBJECTIVE: Follistatin binds and inactivates activins, which are potent inhibitors of muscle growth and metabolism and are currently being developed for the treatment of obesity and type 2 diabetes (T2D). We have recently reported that follistatin is regulated by glucose (and not lipids) and can prospectively predict the metabolic improvements observed after bariatric surgery. We utilized novel assays herein to investigate whether activins are regulated by glucose or lipids, whether their circul...
Source
#1Nikolaos Perakakis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 10
#2Alexander Kokkinos (UoA: National and Kapodistrian University of Athens)H-Index: 16
Last. Christos S. Mantzoros (Harvard University)H-Index: 108
view all 9 authors...
Abstract Aims Bariatric surgery leads to profound and sustainable weight loss. Gastrointestinal hormones are involved in energy and glucose homeostasis, thus postoperative changes of their circulating levels may be mediating future weight loss. To investigate how the circulating concentrations of gastrointestinal hormones change in response to the most common types of bariatric operation and whether these changes can predict future weight loss. Materials and Methods We measured circulating GLP-1...
6 CitationsSource
#1Nikolaos Perakakis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 10
#2Stergios A. Polyzos (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 34
Last. Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 108
view all 7 authors...
Abstract Background Non-alcoholic fatty liver disease (NAFLD) affects 25–30% of the general population and is characterized by the presence of non-alcoholic fatty liver (NAFL) that can progress to non-alcoholic steatohepatitis (NASH), liver fibrosis and cirrhosis leading to hepatocellular carcinoma. To date, liver biopsy is the gold standard for the diagnosis of NASH and for staging liver fibrosis. This study aimed to train models for the non-invasive diagnosis of NASH and liver fibrosis based o...
10 CitationsSource
#1Natia Peradze (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 3
#2Olivia M. Farr (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 22
Last. Christos S. Mantzoros (Harvard University)H-Index: 108
view all 6 authors...
Long-term treatment with up to 1.8 mg liraglutide improves cardiovascular and all-cause mortality in patients with type 2 diabetes at high risk for cardiovascular disease (CVD) and is currently under investigation in subjects without diabetes. Aim of our study was to investigate whether high dose (3 mg) short-term (5 weeks) treatment with liraglutide in obese patients with no overt type 2 diabetes affects metabolites, lipid and lipoprotein profile and components of activin–follistatin axis in ca...
3 CitationsSource
#1Laura Potasso (University of Freiburg)
#2Nikolaos Perakakis (University of Freiburg)H-Index: 10
Last. Katharina Laubner (University of Freiburg)H-Index: 8
view all 9 authors...
Background The single nucleotide polymorphism in TCF7L2 rs7903146 is associated with an increased risk of type 2 diabetes mellitus and gestational diabetes mellitus. Mechanisms by which this mutation acts, and its impact on the clinical course of the diseases remain unclear. Here we investigated the clinical impact of the T risk allele in women with gestational diabetes mellitus. Methods We genotyped the C/T polymorphism in 164 Caucasian women with GDM (German n=114; Greek n=50). The impact of t...
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#1Eleni Pilitsi (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 2
#2Natia Peradze (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 3
Last. Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 108
view all 4 authors...
Abstract Objective It remains unclear whether food deprivation induces changes in components of the GH/IGF-1/IGFBPs axis and if yes, which ones are mediated by leptin, an adipocyte secreted hormone regulating neuroendocrine response to energy deprivation in animals and humans. We aimed to investigate components of the axis that have not been studied to date, i.e. IGF-binding proteins (IGFBPs) and related proteases (total and intact IGFBP 3 and IGFBP 4, total IGFBP 5, PAPPA, PAPPA2 and Stanniocal...
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#1Niki Katsiki (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 2
#1Niki Katsiki (BIDMC: Beth Israel Deaconess Medical Center)
Last. Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 108
view all 3 authors...
5 CitationsSource
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