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Chun Zhang
Huazhong University of Science and Technology
Histone deacetylaseDiabetic nephropathyKidneyCancer researchBiology
7Publications
5H-index
227Citations
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Publications 5
Newest
#1Hua Su (HUST: Huazhong University of Science and Technology)
#2Ding Gao (CAS: Chinese Academy of Sciences)
Last. Chun Zhang (HUST: Huazhong University of Science and Technology)H-Index: 5
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#1Jian Guo (SDU: Shandong University)H-Index: 2
#2Ziying Wang (SDU: Shandong University)H-Index: 14
Last. Fan Yi (SDU: Shandong University)H-Index: 19
view all 16 authors...
Rationale: Endothelial dysfunction is an important determinant risk factor for the development of hypertension and its complications. Thus, identification of potential therapeutic targets for preventing endothelial dysfunction has major clinical importance. Emerging evidence indicates that epigenetic modifications are closely associated with the regulation of endothelial function. Among them, histone deacetylase (HDAC)-mediated epigenetic processes in vascular homeostasis and cardiovascular dise...
3 CitationsSource
#1Min Liu (SDU: Shandong University)H-Index: 3
#2Kaili Liang (SDU: Shandong University)H-Index: 2
Last. Fan Yi (SDU: Shandong University)H-Index: 19
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Podocyte injury is a major determinant of proteinuric kidney disease and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we show that histone deacetylase Sirt6 protects against podocyte injury through epigenetic regulation of Notch signaling. Sirt6 is downregulated in renal biopsies from patients with podocytopathies and its expression correlates with glomerular filtration rate. Podocyte-specific deletion of Sirt6 exacerbates podo...
31 CitationsSource
#1Meng Zhou (SDU: Shandong University)H-Index: 5
#2Wei Tang (SDU: Shandong University)H-Index: 7
Last. Fan Yi (SDU: Shandong University)H-Index: 19
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Progranulin (PGRN), an autocrine growth factor, has multiple physiological functions and is widely involved in the pathogenesis of many types of diseases. The pivotal anti-inflammatory function of PGRN in rheumatoid arthritis encouraged us to examine the role of PGRN in acute kidney injury (AKI). We found that levels of PGRN were significantly reduced in the kidney in a mouse model of renal ischemia/reperfusion injury. We also observed that PGRN deficiency (Grn −/− mice) significantly aggravated...
48 CitationsSource
#1Xiaojie Wang (SDU: Shandong University)H-Index: 9
#2Jiang Liu (SDU: Shandong University)H-Index: 4
Last. Fan Yi (SDU: Shandong University)H-Index: 19
view all 16 authors...
Studies have highlighted the importance of histone deacetylase (HDAC)-mediated epigenetic processes in the development of diabetic complications. Inhibitors of HDAC are a novel class of therapeutic agents in diabetic nephropathy, but currently available inhibitors are mostly nonselective inhibit multiple HDACs, and different HDACs serve very distinct functions. Therefore, it is essential to determine the role of individual HDACs in diabetic nephropathy and develop HDAC inhibitors with improved s...
99 CitationsSource
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