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Takahisa Hiramitsu
83Publications
10H-index
279Citations
Publications 84
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Complete parathyroidectomy (PTx) is essential during total PTx for secondary hyperparathyroidism (SHPT) to prevent recurrent and persistent hyperparathyroidism. Pre-operative imaging evaluations, including computed tomography (CT), ultrasonography (US), and Tc-99m sestamibi (MIBI) scans, are commonly performed. Between June 2009 and January 2016, 291 patients underwent PTx for SHPT after pre-operative evaluations involving CT, US, and MIBI scans, and the diagnostic accuracies of these imaging mo...
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Abstract Introduction Recent reports have described an increased risk of renal disease in living kidney donors compared with the general population. However, these reports do not detail the outcomes of medically complex living donors (MCLDs) with preoperative comorbidities (PCs) such as hypertension, dyslipidemia, glucose intolerance, and obesity. Analysis of living donors with end-stage renal disease (ESRD) has shown that these PCs may contribute significantly to the development of ESRD. We aim...
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Abstract Everolimus (EVR) is often administered with cyclosporine A (CsA), according to an established protocol. Although the administration protocol of EVR with tacrolimus (TAC) has not been established, it has been clinically demonstrated that a higher dose of EVR is necessary when used in combination with TAC than with CsA. In this study, we aimed to determine the optimal dose of EVR administered with TAC to maintain a similar EVR level in the blood to that observed when EVR is administered w...
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#1Tetsuhiko Sato (Memorial Hospital of South Bend)H-Index: 17
#2Yamato Kikkawa (Tokyo University of Pharmacy and Life Sciences)H-Index: 30
Last.Masafumi Fukagawa (Tokai University)H-Index: 49
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#1Manabu OkadaH-Index: 6
#2Takahisa HiramitsuH-Index: 10
Last.Yoshihiro TominagaH-Index: 28
view all 8 authors...
Background The effect of parathyroidectomy (PTx) timing on serum calcium (Ca) levels and renal functions in renal transplant recipients with severe hyperparathyroidism (HPT) remains unclear. We retrospectively aimed to investigate and compare the clinical data of patients who underwent pre- and post-transplant PTx and elucidated the impact of PTx timing on serum Ca levels and renal graft outcomes after renal transplantation (RTx).
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#1Makoto Tsujita (Nagoya University)H-Index: 7
#2Tomoki Kosugi (Nagoya University)H-Index: 26
Last.Yoshihiko WataraiH-Index: 15
view all 13 authors...
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#1Makoto Tsujita (Memorial Hospital of South Bend)
#2Kazuharu Uchida (Memorial Hospital of South Bend)H-Index: 1
Last.Kunio Morozumi (Memorial Hospital of South Bend)H-Index: 23
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#1Shunji NarumiH-Index: 7
#2Yoshihiko WataraiH-Index: 15
Last.Takaaki KobayashiH-Index: 24
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Abstract Purpose We evaluated de novo donor-specific antibody (DSA) production of everolimus (EVR)-based immunosuppression for primary kidney transplant recipients involved in the A1202 study at our institute. Methods From March 2008 to August 2009, 24 recipients were prospectively randomized into 2 groups. The EVR group received reduced cyclosporin A and EVR. The standard protocol (STD) group received standard cyclosporin A and mycophenolate mofetil. Both groups received basiliximab and steroid...
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#1Manabu Okada (Aichi Medical University)H-Index: 6
#2Yoshihiko WataraiH-Index: 15
Last.Takaaki Kobayashi (Aichi Medical University)H-Index: 24
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Abstract Recently, in vitro experiments have demonstrated that anti-blood group A/B antibody binding to endothelial cells induce a protective effect against antibody-mediated injury. This study aimed to clarify the potential clinical benefit of ABO incompatibility in donor-specific HLA antibody (DSA)-induced chronic antibody-mediated rejection (ABMR). We enrolled 215 ABO-incompatible renal transplant (ABO-I) and 467 ABO-identical/compatible renal transplant recipients (ABO-Id/C). The prevalence ...
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#1Makoto Tsujita (Nagoya University)H-Index: 7
#2Tomoki Kosugi (Nagoya University)H-Index: 26
Last.Shoichi Maruyama (Nagoya University)H-Index: 39
view all 10 authors...
Abstract Objective To improve the long-term survival rate after kidney transplantation (KTx), allograft injury should be identified as soon as possible. Regardless of aggressive immunosuppressive therapies, recipients of kidney transplants still have a significant risk of graft failure. No specific predictor for the progression of chronic kidney disease (CKD) after KTx has yet been found. Aberrant molecular mechanisms involving the αKlotho-fibroblast growth factor (FGF) 23 axis may be a useful d...
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