Jian-ping Guo
Genome-wide association studyGeneticsNatural selectionBiologyGenetic architecture
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Publications 4
#1Jian-ping Guo (UQ: University of Queensland)H-Index: 3
#2Andrew Bakshi (UQ: University of Queensland)H-Index: 1
Last. Jian Yang (WMU: Wenzhou Medical College)H-Index: 113
view all 8 authors...
Genome-wide association studies (GWAS) in samples of European ancestry have identified thousands of genetic variants associated with complex traits in humans. However, it remains largely unclear whether these associations can be used in non-European populations. Here, we seek to quantify the proportion of genetic variation for a complex trait shared between continental populations. We estimated the between-population correlation of genetic effects at all SNPs (rg) or genome-wide significant SNPs...
2 CitationsSource
#1Jian-ping Guo (UQ: University of Queensland)H-Index: 3
#2Jian Yang (UQ: University of Queensland)H-Index: 97
Last. Peter M. Visscher (UQ: University of Queensland)H-Index: 109
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Natural selection can shape the genetic architecture of complex traits. In human populations, signals of positive selection at genetic loci have been detected through a variety of genome-wide scanning approaches without the knowledge of how genes affect traits or fitness. In the past decade, genome-wide association studies (GWAS) have provided unprecedented insights into the genetic basis of quantitative variation in complex traits. Summary statistics generated from these GWAS have been shown to...
8 CitationsSource
#1Jian-ping Guo (UQ: University of Queensland)H-Index: 3
#2Yang Wu (UQ: University of Queensland)H-Index: 13
Last. Jian Yang (UQ: University of Queensland)H-Index: 97
view all 9 authors...
There are mean differences in complex traits among global human populations. We hypothesize that part of the phenotypic differentiation is due to natural selection. To address this hypothesis, we assess the differentiation in allele frequencies of trait-associated SNPs among African, Eastern Asian, and European populations for ten complex traits using data of large sample size (up to ~405,000). We show that SNPs associated with height ( $P = 2.46 \times 10^{ - 5} P = 2.46 × 1 0 - 5 ), waist-t...
19 CitationsSource
#1Yanying LiuH-Index: 10
#2Li LongH-Index: 6
Last. Zhanguo LiH-Index: 26
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Background Rheumatoid arthritis (RA) is characterized by inflammation of the synovial membrane, leading to invasion of synovial tissue into the adjacent cartilage matrix with degradation of articular cartilage and bone as a consequence. Dickkopf-1 (DKK-1) and osteoprotegerin (OPG) have been demonstrated to be key molecules involved in bone erosion and bone remodeling. The aim of this study was to explore the potential role of DKK-1 and OPG in different stage of RA. Methods The protein levels of ...
19 Citations