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Yuanqing He
Jiangsu University
11Publications
6H-index
88Citations
Publications 11
Newest
#1Jinyan Gu (Jiangsu University)H-Index: 3
#2Haihui Zhang (Jiangsu University)H-Index: 11
Last.Yuanqing He (Jiangsu University)H-Index: 6
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Abstract To ascertain the preliminary structural characteristics and biological activity of different fractions of polysaccharides from Sagittaria sagittifolia L. (SPCs) by ultrasonic assisted extraction (UAE), four new polysaccharides (SPC-60, SPC-70, SPC-80 and SPC-90) were successively fractionated by ethanol. The results implied that except for neutral sugar, four contained proteins and uronic acids in their structure, which were further confirmed by the ultraviolet and infrared spectra. Mol...
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#1Yuanqing HeH-Index: 6
Last.Haile MaH-Index: 19
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Background: Dietary proteins are known for their wide range of nutritional, functional and biological properties. Although the total amount of proteins may be obtained from mixtures, its “availability” for absorption in the gut is in many cases quite uncertain or even varies for the same food depending on processing conditions, the presence of other components, and so on. Methods: To obtain accurate protein hydrolysate absorption data, we have developed a small intestine model (SIM) to test them...
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#1Haihui Zhang (Jiangsu University)H-Index: 11
#2Yuanyuan Dai (Jiangsu University)
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 8 authors...
This research investigated the influence of extremely low frequency magnetic fields (ELF-MF; 50 Hz, 8 mT, 4 h per day, for 28 days) on calcium ion signaling and the double messenger system in the hippocampus of mice. Messengers that were studied included: G-protein, Ins(1,4,5)P3 (IP3), diacylglycerol (DAG), cAMP-dependent protein kinase (PKA), and Ca2+-dependent protein kinase C (PKC). The results showed that ELF-MF caused an increase in the levels of Gi protein, IP3, DAG, PKA and PKC beta, calc...
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#1Chunchun Yin (Jiangsu University)H-Index: 2
#2Xiaoping Luo (Jiangsu University)H-Index: 7
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
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Abstract The present study investigated the protective effects of lotus seedpod procyanidins (LSPCs) on extremely low frequency electromagnetic field (ELF-EMF)-induced neurotoxicity in primary cultured rat hippocampal neurons and the underlying molecular mechanism. The results of MTT, morphological observation, superoxide dismutase (SOD) and malondialdehyde (MDA) assays showed that compared with control, incubating neurons under ELF-EMF exposure significantly decreased cell viability and increas...
6 CitationsSource
#1Xiaoping Luo (Jiangsu University)H-Index: 7
#2Meng Chen (Jiangsu University)H-Index: 3
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
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Abstract With the increasing use of electromagnetic technology, the effects of extremely low-frequency electromagnetic fields (ELF-EMF) on biological systems, central neurotransmitter systems, and human health have attracted extensive attention worldwide. In this study, lotus seedpod procyanidins (LSPCs) were evaluated for their protective effects on ELF-EMF induced oxidative stress injury in mice. Sixty male ICR mice were used for the experiment. The mice were randomly divided into five equal g...
7 CitationsSource
#1Haihui Zhang (Jiangsu University)H-Index: 11
#2Xiaoping Luo (Jiangsu University)H-Index: 7
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 9 authors...
Abstract Procyanidins from Castanea mollissima Bl. shell (CSPCs) induced autophagy and apoptosis in HepG2 cells and its mechanism remains to be examined. In this paper, autophagy was measured by the lipid modification of light chain-3 (LC3) and the formation of autophagosomes. Hoechst 33258 staining and flow cytometer analysis were used to measure apoptosis. The western blot analysis was used to examine the effects of CSPCs on the expression of LC3, PI3K, phosphorylation of AKT, mTOR, Bcl-2, Bad...
8 CitationsSource
#1Yuqing Duan (Jiangsu University)H-Index: 11
#2Hui Xu (Jiangsu University)H-Index: 1
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
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Abstract In this study, autophagic effect of procyanidins from lotus ( Nelumbo nucifera Gaertn.) seedpod (LSPCs) on human hepatoma G2 (HepG2) cells, and the inherent correlation between autophagic levels and reactive oxygen species (ROS) generation were investigated. The results showed that LSPCs increased monodansylcadaverine (MDC) fluorescence intensity and LC3-I/LC3-II conversion in HepG2 cells. In addition, the typically autophagic characteristics (autophagosomes and autolysosomes) were obse...
5 CitationsSource
#1Yuqing Duan (Jiangsu University)H-Index: 11
#2Jiajia Ke (Jiangsu University)H-Index: 3
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 6 authors...
Abstract The autophagy of human hepatoma G2 (HepG2) cells induced by procyanidins from chestnut ( Castanea mollissima Bl.) shell (CSPCs) was investigated, and the inherent relationship between autophagic levels and reactive oxygen species (ROS) generation was studied. The results showed that CSPCs induced HepG2 cell death in a time- and concentration-dependent manner, increased the accumulation of autophagolysosomes and microtubule-associated proteins light chain 3-II (LC3-II, a marker of autoph...
11 CitationsSource
#1Yuqing Duan (Jiangsu University)H-Index: 11
#2Zhigao Wang (Jiangsu University)H-Index: 2
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 8 authors...
Lotus seedpod procyanidins (LSPCs) could effectively prevent learning and memory damage and oxidative damage caused by extremely low frequency electromagnetic field (ELF-EMF) exposure. However, LSPCs protect neurons from ELF-EMF-induced damage by mechanisms currently not clear. An excessive release of glutamate is considered to be one of the molecular mechanisms of neuronal damage in several neurological diseases. In this study we determined whether the ELF-EMF (50 Hz, 8 mT, 28 days) exposure in...
16 CitationsSource
#1Haihui Zhang (Jiangsu University)H-Index: 11
#2Jiajia Ke (Jiangsu University)H-Index: 3
Last.Xiaobo Sun (Academy of Medical Sciences, United Kingdom)H-Index: 7
view all 10 authors...
Abstract Significant cytotoxic effects of procynadins from chestnut ( Castanea mollissima Bl.) s hell (CSPC) on human hepatoma G2 (HepG2) cells were found in vitro . CSPC could inbibit HepG2 proliferation in a dose-dependent manner (100–400 μg/mL), arrest cell cycle in the G 0 /G 1 phase, induce apoptosis and trigger necrosis of HepG2. Proapoptotic effect of CSPC was evidenced by nuclear condensation, internucleosomal DNA fragmentation. Treatment of HepG2 cells with CSPC caused a loss of mitocho...
13 CitationsSource
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