Douglas J. MacKenzie
University of Glasgow
Major histocompatibility complexAdenocarcinomaGeneral surgeryMedicineAntigen presentation
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Publications 4
#1Douglas J. MacKenzie (Glas.: University of Glasgow)H-Index: 2
#2Neil Robertson (Glas.: University of Glasgow)H-Index: 36
Last. Peter D. Adams (Glas.: University of Glasgow)H-Index: 47
view all 11 authors...
Summary Approximately 10% of human colorectal cancer (CRC) are associated with activated BRAFV600E mutation, typically in absence of APC mutation and often associated with a CpG Island Methylator (CIMP) phenotype. To protect from cancer, normal intestinal epithelial cells respond to oncogenic BRAFV600E by activation of intrinsic p53 and p16-dependent tumor suppressor mechanisms, such as cellular senescence. Conversely, CIMP is thought to contribute to bypass of these tumor suppressor mechanisms,...
#1John van Tuyn (Glas.: University of Glasgow)H-Index: 19
#2Farah Jaber-Hijazi (Glas.: University of Glasgow)H-Index: 6
Last. Peter D. Adams (Glas.: University of Glasgow)H-Index: 47
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On acquisition of an oncogenic mutation, primary human and mouse cells can enter oncogene-induced senescence (OIS). OIS is characterized by a stable proliferation arrest and secretion of proinflammatory cytokines and chemokines, the senescence-associated secretory phenotype. Proliferation arrest and the senescence-associated secretory phenotype collaborate to enact tumor suppression, the former by blocking cell proliferation and the latter by recruiting immune cells to clear damaged cells. Howev...
7 CitationsSource
#2Neil A. RobertsonH-Index: 9
Last. Peter D. AdamsH-Index: 47
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#1Nigel B. Jamieson (Glas.: University of Glasgow)H-Index: 35
#2Simon Denley (Glas.: University of Glasgow)H-Index: 4
Last. Donald C. McMillan (Glas.: University of Glasgow)H-Index: 72
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Background Outcome prediction after resection with curative intent for pancreatic ductal adenocarcinoma remains a challenge. There is increasing evidence that the presence of an ongoing systemic inflammatory response is associated with poor outcome in patients undergoing resection for a variety of common solid tumors. Our aim was to prospectively evaluate the prognostic value of tumor- and patient-related factors including the systemic inflammatory response in patients undergoing potentially cur...
64 CitationsSource