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Wei Shan
Sichuan University
NanoparticleMaterials scienceMucusPeptideDrug delivery
25Publications
13H-index
578Citations
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Publications 24
Newest
#1Yucheng Xiang (Sichuan University)H-Index: 1
#2Wei Shan (Sichuan University)H-Index: 13
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 3 authors...
Abstract Although cell penetrating peptides (CPPs) have been extensively studied as an approach to deliver anti-cancer drugs into the tumor cells for the last 30 years, no FDA-approved CPP-based drugs are available, implying that the existing CPPs may have less efficiency in human or have side effects such as toxicity. Herein, we established a tumor targeting drug delivery system by attaching a human-derived cell-penetrating peptide dNP2 (CKIKKVKKKGRKKIKKVKKKGRK) to N-(2-hydroxypropyl)-methacryl...
2 CitationsSource
#1Yaxian Zheng (Sichuan University)H-Index: 4
#2Jiawei Wu (Sichuan University)H-Index: 3
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 10 authors...
In oral delivery of biomacromolecules, ligand-modified nanoparticles (NPs) have emerged as a promising tool to improve the epithelial uptake of the loaded protein/peptide. Unfortunately, the stability and the transport mechanisms of the biotherapeutics during the intracellular transportation still remained unclear, leading to the poor transepithelial efficiency. Additionally, developing novel approaches to simultaneously monitor the payload bioactivity during the transport processes is veritably...
3 CitationsSource
#1Lei Wu (Sichuan University)H-Index: 7
#2Yuli Bai (Sichuan University)H-Index: 1
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 7 authors...
The intestinal epithelium constitutes a major barrier for orally delivered nanoparticles (NPs). Although surface ligand modification can increase cellular uptake of NPs, the transepithelial transport of active targeting NPs is relatively limited. The phenomenon is described as “easy entry, hard transcytosis”. However, underlying mechanisms and potential solutions of this phenomenon are unclear. Here, butyrate modified polyethylene glycol coated NPs (Bu-PEG NPs) were chosen as the model active ta...
3 CitationsSource
#1Jiawei Wu (Sichuan University)H-Index: 3
#2Yaxian Zheng (Sichuan University)H-Index: 4
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 6 authors...
Nanoparticles (NPs) for oral delivery of peptide/protein drugs are largely limited due to the coexistence of intestinal mucus and epithelial barriers. Sequentially overcoming these two barriers is intractable for a single nanovehicle due to the requirements of different or even contradictory surface properties of NPs. To solve this dilemma, a mucus-penetrating virus-inspired biomimetic NP with charge reversal ability (P-R8-Pho NPs) was developed by densely coating poly(lactic-co-glycolic acid) N...
19 CitationsSource
#1Min Liu (Sichuan University)H-Index: 9
#2Lei Wu (Sichuan University)H-Index: 7
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 5 authors...
Oral administration of targeted nanoparticles (NPs) has great potential in biomedical applications and displays several putative advantages for protein and peptide drug delivery. However, one important limiting factor is the presence of free ligands or endogenous counterparts, which competitively inhibit the ligand–receptor interaction of the actively targeted NPs. We hypothesize that NPs targeted to the transferrin (Tf) and transferrin receptor (TfR) complex may overcome this competitive inhibi...
1 CitationsSource
#1Yi Cui (Sichuan University)H-Index: 5
#2Wei Shan (Sichuan University)H-Index: 13
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 9 authors...
Ligand-modified nanoparticles (NPs) are an effective tool to increase the endocytosis efficiency of drugs, but these functionalized NPs face the drawback of “easy uptake hard transcytosis” in the oral delivery of proteins and peptides. Adversely, the resulting deficiency in transcytosis has not attracted much attention. Herein, NPs modified with the low-density lipoprotein receptor (LDLR) ligand NH2-C6-[cMPRLRGC]c-NH2, i.e., peptide-22 (P22NPs) were fabricated to investigate strategies related t...
4 CitationsSource
#1Lei Wu (Sichuan University)H-Index: 7
#2Wei Shan (Sichuan University)H-Index: 13
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 4 authors...
Abstract Although nanotechnology has been investigated during recent years to increase the bioavailability and therapeutic effects of mucosal administrated drugs, numerous barriers (e.g., pH environment, enzymes and mucus) still limit the delivery efficiency. And the epithelium would also affect the systemic mucosal drug delivery. Amongst all the barriers, the protective mucus has drawn more and more attention, which strongly hinders the accessibility of nanovehicles to epithelium. Therefore, tr...
14 CitationsSource
#1Wei Shan (Sichuan University)H-Index: 13
#2Yi Cui (Sichuan University)H-Index: 5
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 8 authors...
Abstract Development of nanoparticle (NP) to simultaneously overcome the diffusion and absorption barrier has drawn much attention. Our group recently demonstrated that the virus mimicking dilauroylphosphatidylcholine functionalized NP (DLPC-NP) could rapidly penetrate across mucus layer and subsequently enter epithelia effectively, and exhibited high potential for oral drug delivery. However, the safety of the NP has provoked some scientific concerns, which debates from their properties that ci...
1 CitationsSource
#1Lei Wu (Sichuan University)H-Index: 7
#2Min Liu (Sichuan University)H-Index: 9
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 7 authors...
Abstract Ligand-functionalization can increase the affinity of nanoparticles (NPs) with targeted cells. However, one major defect of ligands still exists in oral administration: limited receptor recognition. The hindrance of mucus network and deactivation of enzymes severely challenge the targeting efficiency of macromolecular ligands. Inspired by “molecular exchange” between intestinal microbiota and host cells, we anchored microbiota metabolite butyrate on classical “mucus-inert” polyethylene ...
9 CitationsSource
#1Lei Wu (Sichuan University)H-Index: 7
#2Min Liu (Sichuan University)H-Index: 9
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 6 authors...
Abstract Lipid nanoparticles (LNs) are widely investigated for oral drug delivery, and for achieving significant advantages in colloidal stability, biocompatibility and scaled-up possibility. However, researchers face challenge of developing methods to improve the ability of LNs in overcoming multiple barriers (i.e., mucus and epithelium barrier) in gastrointestinal (GI) tract because of the contradictory requirement of nanoparticle (NP) surface properties in the two processes. Therefore, we des...
9 CitationsSource
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