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Al-Shaimaa F.F. Ahmed
Minia University
AntioxidantOxadiazoleOximeAnti-inflammatoryPharmacology
3Publications
2H-index
21Citations
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Publications 10
Newest
#1Alaa H.F. Shehata (Minia University)
#2Al-Shaimaa F.F. Ahmed (Minia University)H-Index: 2
Last. Gehan H. Heeba (Minia University)H-Index: 12
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Abstract Aim The neuronal damage and accompanied functional deficits induced by cerebral ischemia are among the most common causes of disabilities in adults. Activation of subtypes of peroxisome proliferator-activated receptors (PPARs); PPAR-α and PPAR-γ have shown neuroprotective effects in different neurodegenerative diseases including stroke. Thus, this study aimed to compare the effects of two different agonists: PPAR-α (fenofibrate) and PPAR-γ (pioglitazone) as well as the effect of their c...
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Background: Peptic ulcer disease, a painful lesion of the gastric mucosa, is considered one of the most common gastrointestinal disorders. This study aims to investigate the formulation of pumpkin seed oil (PSO)-based nanostructured lipid carriers (NLCs) to utilize PSO as the liquid lipid component of NLCs and to achieve oil dispersion in the nano-range in the stomach. Methods: Box-Behnken design was utilized to deduce the optimum formula with minimum particle size. The optimized PSO-NLCs formul...
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#1Osama A. A. AhmedH-Index: 9
#2Usama A. FahmyH-Index: 8
Last. Nabil A. AlhakamyH-Index: 7
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Peptic ulcer disease is an injury of the alimentary tract that leads to a mucosal defect reaching the submucosa. This study aimed to formulate and optimize omega-3 oil as a self-nanoemulsifying drug delivery system (SNEDDS) to achieve oil dispersion in the nano-range in the stomach to augment omega-3 oil gastric ulcer protection efficacy. Three SNEDDS components were selected as the design factors: the concentrations of the oil omega-3 (X1, 10–30%), the surfactant tween 20 and Kolliphor mixture ...
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#1Yasmine F. Ibrahim (Minia University)H-Index: 1
#2Rabab A. Moussa (Minia University)H-Index: 1
Last. Al-Shaimaa F.F. Ahmed (Minia University)H-Index: 2
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Acute lung injury (ALI) and acute kidney injury (AKI) are major causes of sepsis-induced mortality. The objective of the study is to evaluate the effect of tocilizumab (TCZ), an IL-6 receptor inhibitor, in sepsis-induced ALI and AKI using the cecal ligation and puncture (CLP) rat model of sepsis. Clinical and experimental studies have demonstrated the importance of IL-6 in sepsis; however, the role of TCZ has not been investigated. Rats subjected to CLP developed histological evidence of ALI and...
1 CitationsSource
#1Mohamed Mahran (Minia University)
#2Omar H. El-garhy (Minia University)H-Index: 1
Last. Eman Alaaeldin (Minia University)H-Index: 1
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Many herbal products have been used to control blood glucose level and minimize complications of diabetes mellitus. However, the feasibility of using such herbal product has been hindered due to the lower stability of their extracts and patients incompliance. Objective: An optimized fast disintegrating tablet preparation of spray dried aqueous extract of poly herbal blend has been formulated to maximize the therapeutic activity of such herbal extract. Methods: different ratios of superdisintegra...
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#1Al-Shaimaa F.F. Ahmed (Minia University)H-Index: 2
#2Asmaa M. A. Bayoumi (Minia University)H-Index: 1
Last. Mekky M. Abouzied (Taibah University)H-Index: 10
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Oxidative stress plays an important role in the development of sepsis and its associated serious consequence leading to multiple organ failure and death. Since the liver and the lungs are among the early affected organs responsible for the mortality in sepsis, we investigated the effect of Tempol, a superoxide dismutase mimetic agent, on lung and liver injuries in a cecal ligation and puncture (CLP)-induced sepsis. Septic animals were given Tempol either before or after CLP procedure. Sepsis out...
1 CitationsSource
#1Asmaa S.A. Hammad (Minia University)
#2Al-Shaimaa F.F. Ahmed (Minia University)H-Index: 2
Last. Ashraf Taye (Minia University)H-Index: 13
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Abstract Endothelial dysfunction is a common complication of diabetes that mainly stems from increased reactive oxygen species, which makes antioxidants of great benefit. Resveratrol (RSV) is an antioxidant that shows protective effects in a variety of disease models where the ameliorative effect appears to be mediated, in part, via heme oxygenase-1 (HO-1) induction. However, the pathophysiological relevance of HO-1 in the ameliorative response of RSV in endothelial dysfunction is not clearly de...
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#1Heba S. Abd-Ellah (Minia University)H-Index: 2
#2Mohamed Abdel-Aziz (Minia University)H-Index: 14
Last. Al-Shaimaa F.F. Ahmed (Minia University)H-Index: 2
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Abstract A series of new 1,3,4-oxadiazole/oxime hybrids were synthesized and designed as potent COX inhibitors. The prepared compounds were evaluated for their anti-inflammatory, antioxidant and ulcerogenic activities. The results indicated that the prepared compounds exhibited remarkable anti-inflammatory activity with (69.60–109.60% of indomethacin activity) after 4 h. In vitro COX inhibitory assay showed that compounds 6d and 7h are potent COX inhibitors with IC 50 of (1.10–0.94) and (2.30–5....
7 CitationsSource
#1Heba S. Abd-Ellah (Minia University)H-Index: 2
#2Mohamed Abdel-Aziz (Minia University)H-Index: 14
Last. Al-Shaimaa F.F. Ahmed (Minia University)H-Index: 2
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Abstract A novel group of 1,3,4-oxadaiazoles, a group known for their anti-inflammatory activity, is hybridized with nitric oxide (NO) releasing group, oxime, for its gastro-protective action and potential synergistic effect. The synthesized hybrids were evaluated for their anti-inflammatory, analgesic, antioxidant and ulcerogenic activities. Most of the tested compounds showed excellent anti-inflammatory activity with compound 8e being more active than indomethacin. They also showed moderate an...
14 CitationsSource
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