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Vasilis S. Dionellis
University of Geneva
1Publications
1H-index
9Citations
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#1Natalia Lugli (University of Geneva)H-Index: 5
#2Vasilis S. Dionellis (University of Geneva)H-Index: 1
Last.Thanos D. Halazonetis (University of Geneva)H-Index: 51
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Summary The most prevalent single-nucleotide substitution (SNS) found in cancers is a C-to-T substitution in the CpG motif. It has been proposed that many of these SNSs arise during organismal aging, prior to transformation of a normal cell into a precancerous/cancer cell. Here, we isolated single intestinal crypts derived from normal tissue or from adenomas of Apc min/+ mice, expanded them minimally in vitro as organoids, and performed exome sequencing to identify point mutations that had been ...
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