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Marc Tessier-Lavigne
Stanford University
NetrinNeuroscienceAxon guidanceBiologyCell biology
344Publications
124H-index
51.9kCitations
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Publications 317
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#1Zirong Gu (Cincinnati Children's Hospital Medical Center)H-Index: 3
#2Natasha Koppel (Cornell University)
Last. John H. Martin (CUNY: City University of New York)H-Index: 44
view all 11 authors...
Axon guidance molecules and neuronal activity have been implicated in the establishment and refinement of neural circuits during development. It is unclear, however, if these guidance molecule- and activity-dependent mechanisms interact with one another to shape neural circuit formation. The formation of corticospinal (CS) circuits, which are essential for voluntary movements, involves both guidance molecule- and activity-dependent components during development. We previously showed that semapho...
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#1Drew Friedmann (Stanford University)H-Index: 2
#2Albert Pun (Stanford University)H-Index: 3
Last. Liqun Luo (Stanford University)H-Index: 84
view all 9 authors...
The projection targets of a neuronal population are a key feature of its anatomical characteristics. Historically, tissue sectioning, confocal microscopy, and manual scoring of specific regions of interest have been used to generate coarse summaries of mesoscale projectomes. We present here TrailMap, a three-dimensional (3D) convolutional network for extracting axonal projections from intact cleared mouse brains imaged by light-sheet microscopy. TrailMap allows region-based quantification of tot...
2 CitationsSource
#1Christoph Kirst (Rockefeller University)H-Index: 11
#1Christoph Kirst (Rockefeller University)
Last. Marc Tessier-Lavigne (Stanford University)H-Index: 124
view all 11 authors...
Summary The cerebral vasculature is a dense network of arteries, capillaries, and veins. Quantifying variations of the vascular organization across individuals, brain regions, or disease models is challenging. We used immunolabeling and tissue clearing to image the vascular network of adult mouse brains and developed a pipeline to segment terabyte-sized multichannel images from light sheet microscopy, enabling the construction, analysis, and visualization of vascular graphs composed of over 100 ...
3 CitationsSource
#1Marc Tessier-Lavigne (Stanford University)H-Index: 124
Abstract Circumferential axon migrations toward and away from the midline are a major feature of the development of all bilateral animals. Prominent among the guidance cues regulating midline guidance are Netrins, a small family of secreted proteins that have a conserved role across species in attracting some axons to the midline while repelling others away. Netrins also guide other axons throughout the nervous system. In some settings, Netrins guide axons at longrange (over hundreds of micromet...
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#1Alastair J. Tulloch (Brown University)H-Index: 2
#2Shaun Teo (Rockefeller University)H-Index: 3
Last. Alexander Jaworski (Brown University)H-Index: 8
view all 5 authors...
: The two sides of the nervous system coordinate and integrate information via commissural neurons, which project axons across the midline. Commissural neurons in the spinal cord are a highly heterogeneous population of cells with respect to their birthplace, final cell body position, axonal trajectory, and neurotransmitter phenotype. Although commissural axon guidance during development has been studied in great detail, neither the developmental origins nor the mature phenotypes of commissural ...
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#1Fabien G. Lafaille (Rockefeller University)H-Index: 12
#2Oliver Harschnitz (Kettering University)H-Index: 2
Last. Shen-Ying Zhang (Rockefeller University)H-Index: 33
view all 43 authors...
Herpes simplex virus-1 (HSV-1) encephalitis (HSE) is typically sporadic. Inborn errors of TLR3- and DBR1-mediated central nervous system cell-intrinsic immunity can account for forebrain and brainstem HSE, respectively. We report five unrelated patients with forebrain HSE, each heterozygous for one of four rare variants of SNORA31, encoding a small nucleolar RNA of the H/ACA class that are predicted to direct the isomerization of uridine residues to pseudouridine in small nuclear RNA and ribosom...
6 CitationsSource
#1Sayaka Inoue (Stanford University)H-Index: 2
#2Renzhi Yang (Stanford University)H-Index: 3
Last. Nirao M. Shah (Stanford University)H-Index: 26
view all 14 authors...
Summary Behaviors are inextricably linked to internal state. We have identified a neural mechanism that links female sexual behavior with the estrus, the ovulatory phase of the estrous cycle. We find that progesterone-receptor (PR)-expressing neurons in the ventromedial hypothalamus (VMH) are active and required during this behavior. Activating these neurons, however, does not elicit sexual behavior in non-estrus females. We show that projections of PR+ VMH neurons to the anteroventral periventr...
6 CitationsSource
#1Ryan T. Willett (Kettering University)H-Index: 3
#1Ryan T Willett (Kettering University)H-Index: 1
Last. Alexandra L. Joyner (Kettering University)H-Index: 74
view all 13 authors...
For neural systems to function effectively, the numbers of each cell type must be proportioned properly during development. We found that conditional knockout of the mouse homeobox genes En1 and En2 in the excitatory cerebellar nuclei neurons (eCN) leads to reduced postnatal growth of the cerebellar cortex. A subset of medial and intermediate eCN are lost in the mutants, with an associated cell non-autonomous loss of their presynaptic partner Purkinje cells by birth leading to proportional scali...
3 CitationsSource
#1Dylan Kwart (Rockefeller University)H-Index: 5
#2Andrew Gregg (Rockefeller University)H-Index: 2
Last. Marc Tessier-Lavigne (Rockefeller University)H-Index: 124
view all 10 authors...
Summary Familial Alzheimer’s disease (fAD) results from mutations in the amyloid precursor protein (APP) and presenilin (PSEN1 and PSEN2) genes. Here we leveraged recent advances in induced pluripotent stem cell (iPSC) and CRISPR/Cas9 genome editing technologies to generate a panel of isogenic knockin human iPSC lines carrying APP and/or PSEN1 mutations. Global transcriptomic and translatomic profiling revealed that fAD mutations have overlapping effects on the expression of AD-related and endoc...
23 CitationsSource
#1Drew Friedmann (HHMI: Howard Hughes Medical Institute)H-Index: 2
#2Albert Pun (HHMI: Howard Hughes Medical Institute)H-Index: 3
Last. Liqun Luo (HHMI: Howard Hughes Medical Institute)H-Index: 84
view all 9 authors...
The projection targets of a neuronal population are a key feature of its anatomical characterization. Historically, tissue sectioning, confocal microscopy, and manual scoring of specific regions of interest have been used to generate coarse summaries of mesoscale projectomes. We present here TrailMap, a 3D convolutional network for extracting axonal projections from intact cleared mouse brains imaged by light-sheet microscopy. TrailMap allows region-based quantification of total axon content in ...
1 CitationsSource
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