Sinikka Koskinen
Finnish Red Cross
AntibodyImmunologySelective IgA deficiencyMedicineBiology
What is this?
Publications 13
#1Susanna Sainio (Finnish Red Cross)H-Index: 12
#1Susanna Sainio (Finnish Red Cross)H-Index: 5
Last. Sinikka Koskinen (Finnish Red Cross)H-Index: 10
view all 4 authors...
Summary Objective To study the clinical usefulness of maternal anti-HPA-1a antibody levels in predicting severe foetomaternal alloimmune thrombocytopenia (FMAIT). Background Recent studies using an international anti-HPA-1a standard have shown a correlation between maternal antibody levels and neonatal thrombocytopenia. Cut-off values for identifying high-risk pregnancies have also been suggested. Materials In 1986–2010, HPA-1a alloimmunisation was confirmed in 84 women with 129 pregnancies. Mat...
10 CitationsSource
#1Heidi TillerH-Index: 8
#2Marije M. Kamphuis (LUMC: Leiden University Medical Center)H-Index: 6
Last. Magnus Westgren (KI: Karolinska Institutet)H-Index: 2
view all 14 authors...
Objective To characterise pregnancies where the fetus or neonate was diagnosed with fetal and neonatal alloimmune thrombocytopenia (FNAIT) and suffered from intracranial haemorrhage (ICH), with special focus on time of bleeding onset. Design Observational cohort study of all recorded cases of ICH caused by FNAIT from the international No IntraCranial Haemorrhage (NOICH) registry during the period 2001–2010. Setting 13 tertiary referral centres from nine countries across the world. Participants 3...
58 CitationsSource
#1Ricardo C. Ferreira (Genentech)H-Index: 21
#2Qiang Pan-Hammarström (Karolinska University Hospital)H-Index: 39
Last. Timothy W. Behrens (Genentech)H-Index: 75
view all 18 authors...
NIH U19 AI067152 AR043274 Swedish Research Council EURO-PADnet 201549 Stockholm county council Karolinska Institutet Fundacao para a Ciencia e Tecnologia, Portugal SFRH/BD/16281/2004 Yale Center for Human Genetics and Genomics Yale Program on Neurogenetics US National Institutes of Health R01NS057756 U24 NS051869 Nordic Center of Excellence in Disease Genetics
40 CitationsSource
#1Ricardo C. Ferreira (Genentech)H-Index: 21
#2Qiang Pan-Hammarström (Karolinska University Hospital)H-Index: 39
Last. Lennart Hammarström (Karolinska University Hospital)H-Index: 76
view all 19 authors...
Lennart Hammarstrom, Tim Behrens and colleagues report the results of a genome wide association study of selective immunoglobulin A deficiency, the most common form of primary immunodeficiency in humans. They validated previously known HLA haplotype associations and identified a new risk variant in IFIH1.
112 CitationsSource
#1Kaija Javela (Finnish Red Cross)H-Index: 11
#2Riitta Kekomäki (Finnish Red Cross)H-Index: 25
Last. Sinikka Koskinen (Finnish Red Cross)H-Index: 10
view all 3 authors...
Background: Heparin-induced thrombocytopenia (HIT) is a prothrombotic immune-mediated adverse drug reaction. Antigen and platelet activation assays are used for detection of antibodies. Quantitative results from platelet factor 4 (PF4)-dependent immunoassays may lead to inter-laboratory standardization of measurements. Objectives: The aim was to modify a PF4-dependent immunoassay to measure PF4/heparin antibodies quantitatively. Methods: Over five consecutive years, 1070 samples from thrombocyto...
5 CitationsSource
#1Katri Haimila (Finnish Red Cross)H-Index: 19
#2Elisabet Einarsdottir (UH: University of Helsinki)H-Index: 20
Last. Päivi Saavalainen (UH: University of Helsinki)H-Index: 23
view all 22 authors...
The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency
34 CitationsSource
A 20-year health follow-up study of 159 initially healthy blood donors with a severe deficiency of serum IgA (<0.05×10−3 g/L) and of 45 donors with decreased serum IgA (0.05×10−3−0.8 g/L) was carried out. The findings indicate that persons with a severe deficiency of and decreased serum IgA who are healthy as young adults have an increased susceptibility to pneumonia and recurrent episodes of other respiratory infections and a higher risk of developing autoimmune diseases in middle age. Vitiligo...
80 CitationsSource
#1Igor Vořechovský (KI: Karolinska Institutet)H-Index: 9
#2Henrik ZetterquistH-Index: 1
Last. Lennart HammarströmH-Index: 76
view all 9 authors...
Screening of close relatives of Swedish patients with selective immunoglobulin A deficiency (IgAD) and common variable immunodeficiency (CVID) for serum immunoglobulin levels has identified the positive family history of IgAD/CVID as the most significant risk factor for developing the disease. The relative risk for siblings of patients with IgAD was estimated to be approximately 50. In 12 of 34 Swedish multiplex families identified in the study, both IgAD and CVID occurred, usually CVID in the p...
102 CitationsSource
#1Sinikka Koskinen (Finnish Red Cross)H-Index: 10
#2Hannele Tölö (Finnish Red Cross)H-Index: 8
Last. Jukka Koistinen (Finnish Red Cross)H-Index: 10
view all 4 authors...
A follow-up study of anti-IgA antibodies in 159 healthy blood donors with severe deficiency of serum IgA ( 1/1000 by HA) appeared in two. In reexaminations anti-IgA antibodies were found in 30 (19%) subjects with severe IgA deficiency and the antibody levels remained relatively constant in those who had high and medium antibody levels. Anti-IgA antibodies were not found in subjects with decreased, but detectable serum IgA. Thus it seems that only those healthy adults who have severe IgA deficien...
20 CitationsSource
#1Igor Vořechovský (KI: Karolinska Institutet)H-Index: 9
#2Sinikka Koskinen (Finnish Red Cross)H-Index: 10
Last. Lennart Hammarström (KI: Karolinska Institutet)H-Index: 76
view all 6 authors...
10 CitationsSource