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Brian M. Keyser
Tulane University
9Publications
8H-index
348Citations
Publications 9
Newest
Published on Aug 1, 2008in Cancer Letters 6.51
James T. Taylor9
Estimated H-index: 9
(Tulane University),
Luping Huang7
Estimated H-index: 7
(Tulane University)
+ 7 AuthorsMing Li6
Estimated H-index: 6
(Tulane University)
Abstract We have measured the expression of T-type Ca 2+ channel mRNA in breast cancer cell lines (MCF-7 (ERα+) using Western blot and quantitative real-time PCR (Q-RT-PCR). These results revealed that the MCF-7 cells express both α 1G and α 1H isoforms of T-type Ca 2+ channels. In order to further clarify the role of T-type Ca 2+ channels in proliferation, we tested the effects of a selective T-type Ca 2+ channel inhibitor NNC-55-0396 on cellular proliferation. MCF-7 (ERα+) cellular proliferati...
Published on Jun 7, 2006in Cardiovascular Drug Reviews
Ming Li6
Estimated H-index: 6
(Tulane University),
J. Bondo Hansen11
Estimated H-index: 11
(Novo Nordisk)
+ 2 AuthorsJames T. Taylor9
Estimated H-index: 9
(Tulane University)
NNC 55-0396 is a structural analog of mibefradil (Ro 40-5967) that inhibits both T-type and high-voltage-activated (HVA) Ca 2+ channels with a higher selectivity for T-type Ca 2+ channels. The inhibitory effect of mibefradil on HVA Ca 2+ channels can be attributed to a hydrolyzed metabolite of the drug: the methoxy acetate side chain of mibefradil is removed by intracellular enzymes, thus it forms (1S,2S)-2-(2-(N-[(3-benzoimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-i...
James T. Taylor9
Estimated H-index: 9
,
Luping Huang7
Estimated H-index: 7
+ 3 AuthorsMing Li23
Estimated H-index: 23
High-voltage-activated (HVA) calcium channels are known to be the primary source of calcium for glucose-stimulated insulin secretion. However, few studies have investigated how these channels can be regulated by chronically elevated levels of glucose. In the present study, we determined the level of expression of the four major HVA calcium channels (N-type, P/Q-type, LC-type, and LD-type) in rat pancreatic β-cells. Using quantitative real-time PCR (QRT-PCR), we found the expression of all four H...
Published on Sep 1, 2005in The Journal of Sexual Medicine 3.65
Xiangbin Zeng5
Estimated H-index: 5
(Tulane University),
Brian M. Keyser8
Estimated H-index: 8
(Tulane University)
+ 1 AuthorsSuresh C. Sikka42
Estimated H-index: 42
(Tulane University)
ABSTRACT Introduction Nitric oxide‐cyclic guanosine monophosphate (NO‐cGMP)‐mediated relaxation of cavernosal smooth muscle during erection is accompanied by a decrease in intracellular calcium concentrations ([Ca 2+ ] i ). However, it is not known whether and how an increase in [Ca 2+ ] i is responsible for (i) initiating smooth muscle contraction/detumescence following relaxation; and (ii) maintaining the penis in a flaccid state under nonstimulating conditions. Aim To elucidate (i) the mechan...
Published on Sep 1, 2005in The Journal of Sexual Medicine 3.65
Xiangbin Zeng5
Estimated H-index: 5
,
Brian M. Keyser8
Estimated H-index: 8
+ 1 AuthorsSuresh C. Sikka42
Estimated H-index: 42
Introduction Nitric oxide‐cyclic guanosine monophosphate (NO‐cGMP)‐mediated relaxation of cavernosal smooth muscle during erection is accompanied by a decrease in intracellular calcium concentrations ([Ca2+]i). However, it is not known whether and how an increase in [Ca2+]i is responsible for (i) initiating smooth muscle contraction/detumescence following relaxation; and (ii) maintaining the penis in a flaccid state under nonstimulating conditions.
Published on Apr 1, 2005in Pediatric Research 2.88
Ming Li23
Estimated H-index: 23
,
Min Zhang7
Estimated H-index: 7
+ 5 AuthorsRichard M Whitehurst6
Estimated H-index: 6
T-Type Ca 2+ Channels Are Involved in High Glucose–Induced Rat Neonatal Cardiomyocyte Proliferation
Published on Jan 16, 2004in Journal of Pharmacology and Experimental Therapeutics 3.62
Luping Huang7
Estimated H-index: 7
,
Brian M. Keyser8
Estimated H-index: 8
+ 6 AuthorsMing Li23
Estimated H-index: 23
Mibefradil is a Ca 2+ channel antagonist that inhibits both T-type and high-voltage-activated Ca 2+ channels. We previously showed that block of high-voltage-activated channels by mibefradil occurs through the production of an active metabolite by intracellular hydrolysis. In the present study, we modified the structure of mibefradil to develop a nonhydrolyzable analog, (1 S , 2 S )-2-(2-( N -[(3-benzimidazol-2-yl)propyl]- N -methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl c...
Published on Feb 1, 2004in American Journal of Physiology-cell Physiology 3.55
Luping Huang7
Estimated H-index: 7
,
Arin Bhattacharjee22
Estimated H-index: 22
+ 4 AuthorsMing Li23
Estimated H-index: 23
Chronic exposure of pancreatic β-cells to high concentrations of glucose impairs the insulin secretory response to further glucose stimulation. This phenomenon is referred to as glucose desensitization. It has been shown that glucose desensitization is associated with abnormal elevation of β-cell basal intracellular free Ca2+ concentration ([Ca2+]i). We have investigated the relationship between the basal intracellular free Ca2+ and the L-type (Cav1.3) Ca2+ channel translocation in insulin-secre...
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