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Sílvia Vieira
University of Minho
FibroinNanotechnologyMaterials scienceGellan gumTissue engineering
22Publications
6H-index
147Citations
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Publications 20
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#1Sílvia Vieira (University of Minho)H-Index: 6
#2Paulina Strymecka (PAN: Polish Academy of Sciences)H-Index: 1
Last. Rui L. Reis (University of Minho)H-Index: 97
view all 13 authors...
Cell-based therapies delivered via intrathecal injection are considered as one of the most promising solutions for the treatment of amyotrophic lateral sclerosis (ALS). Herein, injectable manganese-based biocompatible hydrogel blends were developed, that can allow image-guided cell delivery. The hydrogels can also provide physical support for cells during injection, and at the intrathecal space after transplantation, while assuring cell survival. In this regard, different formulations of methacr...
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#1Alain da Silva Morais (University of Minho)H-Index: 9
#2Sílvia Vieira (University of Minho)H-Index: 6
Last. Rui L. Reis (University of Minho)H-Index: 97
view all 7 authors...
Liver diseases contribute markedly to the global burden of mortality and disease. The limited organ disposal for orthotopic liver transplantation results in a continuing need for alternative strategies. Over the past years, important progress has been made in the field of tissue engineering (TE). Many of the early trials to improve the development of an engineered tissue construct are based on seeding cells onto biomaterial scaffolds. Nowadays, several TE approaches have been developed and are a...
2 CitationsSource
#2Peter Krustrup (University of Southern Denmark)H-Index: 62
Last. Carlo CastagnaH-Index: 54
view all 7 authors...
: This study aimed at examining the suitability of a standard treadmill test (TT), popular intermittent field tests, and small-sided football matches to induce maximal heart rate (HRmax ) in recreational football players. Sixty-six inactive untrained male subjects (age: 39.3 ± 5.8 years, VO2max : 41.2 ± 6.2 mL kg-1 min-1 , body mass: 81.9 ± 10.8 kg, height: 173.2 ± 6.4 cm) were evaluated. On separate occasions, the players were randomly submitted to a progressive VO2max TT, to the Yo-Yo intermit...
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#1Viviana P. RibeiroH-Index: 8
#2S. PinaH-Index: 18
Last. Joaquim M. OliveiraH-Index: 34
view all 9 authors...
Background: Osteochondral defects (OCD) can affect the articular cartilage and subchondral bone tissues, which requires superior therapies for the simultaneous and full restoration of such structurally and biologically different tissues. Methods: Tissue engineered OC grafts were prepared using a horseradish peroxidase (HRP) approach to crosslink silk fibroin (HRP-SF) as the articular cartilage-like layer and an underlying HRP-SF/ZnSrTCP subchondral bone-like layer (HRP-SF/dTCP), through salt-lea...
1 CitationsSource
#1João B. Costa (University of Minho)H-Index: 7
#2Joana Silva-Correia (University of Minho)H-Index: 23
Last. Joel Oliveira (University of Minho)H-Index: 14
view all 9 authors...
The complex meniscus tissue plays a critical role in the knee. The high susceptibility to injury has led to an intense pursuit for better tissue engineering regenerative strategies, where scaffolds play a major role. In this study, indirect printed hierarchical multilayered scaffolds composed by a silk fibroin (SF) upper layer and an 80/20 (w/w) ratio of SF/ionic-doped β-tricalcium phosphate (TCP) bottom layer were developed. Furthermore, a comparative analysis between two types of scaffolds pro...
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#1Sílvia Vieira (University of Minho)H-Index: 6
#2Alain da Silva Morais (University of Minho)H-Index: 9
Last. J. Miguel Oliveira (University of Minho)H-Index: 11
view all 7 authors...
Abstract In this study, methacrylated gellan-gum (GG-MA) heteropolysaccharide is proposed as a hydrogel for drug delivery and bone tissue engineering applications. Calcium-enriched beads obtained from the crosslinking of 1% (w/v) GG-MA solutions with 0.1 M CaCl 2 were investigated, considering their intrinsic capacity to promote self-mineralization by ion binding and deposition. Indeed, when immersed in a physiological environment, the Ca-enriched beads promoted the development of a bone-like ap...
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#1Fernanda Zamboni (UL: University of Limerick)H-Index: 4
#2Sílvia Vieira (University of Minho)H-Index: 6
Last. Maurice N. Collins (UL: University of Limerick)H-Index: 27
view all 5 authors...
Abstract Hyaluronic acid (HA) is a glycosaminoglycan that is found in extracellular tissue in many parts of the body. It is a material of increasing importance to biomaterials science and is finding applications in diverse areas ranging from tissue culture scaffolds to cosmetic materials. This paper reviews the recent research on the role of HA as a immunoprotective and immunomodulatory biomaterial and the importance of HA in combating immune related diseases such as type 1 diabetes, cancer, and...
20 CitationsSource
#1Mariana Carvalho (University of Minho)H-Index: 4
#2Fátima Raquel Maia (University of Minho)H-Index: 2
Last. Joaquim M. Oliveira (University of Minho)H-Index: 34
view all 5 authors...
1 CitationsSource
#1Mariana Carvalho (University of Minho)H-Index: 4
#2Fátima Raquel Maia (University of Minho)H-Index: 2
Last. Joaquim M. Oliveira (University of Minho)H-Index: 34
view all 5 authors...
: Microfluidic devices are now the most promising tool to mimic in vivo like scenarios such as tumorigenesis and metastasis due to its ability to more closely mimic cell's natural microenvironment (such as 3D environment and continuous perfusion of nutrients). In this study, the ability of 2% and 3% enzymatically crosslinked silk fibroin hydrogels with different mechanical properties are tested in terms of colorectal cancer cell migration, under different microenvironments in a 3D dynamic model....
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#1J. Miguel Oliveira (University of Minho)H-Index: 11
#2Luisa Carvalho (University of Minho)H-Index: 1
Last. Piotr Walczak (Johns Hopkins University)H-Index: 27
view all 14 authors...
The prospects for cell replacement in spinal cord diseases are impeded by inefficient stem cell delivery. The deep location of the spinal cord and complex surgical access, as well as densely packed vital structures, question the feasibility of the widespread use of multiple spinal cord punctures to inject stem cells. Disorders characterized by disseminated pathology are particularly appealing for the distribution of cells globally throughout the spinal cord in a minimally invasive fashion. The i...
10 CitationsSource
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