Jean-Pierre Hugot
Centre national de la recherche scientifique
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Publications 220
#1Pauline Vasseur (University of Paris)
#2Emmanuelle DugelayH-Index: 1
Last. Camille Buscail (University of Paris)H-Index: 6
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INTRODUCTION This study aimed to assess the association between incident Crohn's disease (CD) or incident ulcerative colitis (UC) and dietary zinc intake. METHODS NutriNet-Sante cohort's participants who completed at least three 24-hour dietary records were included and incident CD or UC cases were identified. Multivariable Poisson models were performed to assess associations between tertiles of zinc intake and CD or UC. RESULTS Among the 105,832 participants, 27 reported incident CD and 48 repo...
Last. Jérôme VialaH-Index: 16
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Objective Inflammatory bowel diseases (IBDs) are chronic relapsing remitting diseases which potentially result in hospitalisation, requiring long-term outpatient follow-up, ideally by a dedicated, multidisciplinary team. In this team, the IBD nurse is the key point of access for education, advice and support. The aim of this study was to assess the impact of introduction of an IBD nurse position on healthcare use and costs in a tertiary IBD centre. Methods An IBD nurse was instituted in Septembe...
OBJECTIVE: Infliximab (IFX) is a frequent therapeutic option for Crohn disease (CD) patients. Early detection of responders to IFX is critical for the management of CD in order to avoid long-term exposure to the drug without benefit. This retrospective study aimed at analysing which early parameters recorded during the induction period are able to predict response to IFX during the maintenance period in pediatric CD. PATIENTS AND METHODS: Medical records of all CD patients ages from 2 to 18 year...
2 CitationsSource
OBJECTIVES: neurologic adverse effects (NAE) induced by biotherapies have been reported in the literature mainly in adult patients with inflammatory bowel disease (IBD), rheumatic diseases or psoriasis. There are scant data in children. Aims of this study are to report and describe non-infective NAE associated with anti-TNFalpha antibodies in pediatric IBD, and to evaluate their incidence. METHODS: we retrospectively collected all reports of NAE in pediatric IBD treated with anti-TNFalpha antibo...
#1Anthony BuissonH-Index: 17
Last. Nicolas BarnichH-Index: 31
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The macrophages from Crohn’s Disease (CD) patients are defective to control the replication of CD-associated adherent-invasive E. coli (AIEC). We aimed to identify the host factors associated with AIEC replication focusing on polymorphisms related to autophagy. Peripheral blood monocyte-derived macrophages (MDM), obtained from 95 CD patient, 30 ulcerative colitis (UC) patients and 15 healthy subjects, were genotyped for several CD-associated polymorphisms. AIEC bacteria survival increased within...
3 CitationsSource
Abstract Congenital Sodium Diarrhea (CSD) due to SLC9A3 mutation is a rare cause of neonatal diarrhea explained by dysfunction of the Na+/H+ antiporter 3 in intestine. To date only 10 patients have been described. We report a male patient with typical antenatal symptoms (polyhydramnios and intestinal dilation) and neonatal diarrhea with fecal sodium and bicarbonates loss. Next generation sequencing revealed a missense homozygous mutation in exon 6 of the SLC9A3 gene (NM_004174.3:c.1039G > A, NP_...
#1Mallory Chavannes (UdeM: Université de Montréal)H-Index: 2
#2C. Martinez-VinsonH-Index: 4
Last. Ernest G Seidman (Montreal Children's Hospital)H-Index: 3
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BACKGROUND: Ustekinumab [UST] is effective in the treatment of adults with moderate to severe Crohn's disease [CD]. There is a paucity of data on its use in children. AIM: To evaluate the response to UST in children with moderate to severe CD. METHODS: This multicentre retrospective cohort study identified children under 18 years old with CD, who received open-labelled subcutaneous UST. The primary outcome was changes in mean abbreviated Paediatric Crohn's Disease Activity Index [aPCDAI] between...
1 CitationsSource
ABSTRACTObjectives:In adult inflammatory bowel disease (IBD) treated by anti-TNF antibodies, paradoxical psoriasis has an estimated prevalence of 1.6 to 22%, especially in infliximab (IFX)-treated patients. Little is known in the pediatric IBD (PIBD) populations.Methods:All patients aged from 2 to 1
#1Jean-Pierre Hugot (French Institute of Health and Medical Research)H-Index: 41
#2Z. Al Nabhani (French Institute of Health and Medical Research)
Last. Frédérick Barreau (University of Toulouse)H-Index: 14
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NOD2 mutations are key risk factors for Crohn9s disease (CD). NOD2 contributes to intestinal homeostasis by regulating innate and adaptive immunity together with intestinal epithelial function. However, the roles of NOD2 during gut inflammation is not known. We initially observed that NOD2 expression was increased in epithelial cells remote from inflamed areas in CD patients. To explore this finding, Nod2 mRNA expression, inflammation and gut permeability were examined in the small bowel of wild...
#1Audrey Ferrand (French Institute of Health and Medical Research)H-Index: 13
#2Ziad Al Nabhani (French Institute of Health and Medical Research)H-Index: 5
Last. Frédérick Barreau (French Institute of Health and Medical Research)H-Index: 14
view all 6 authors...
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host immune response including epithelial and immune cells. The association of NOD2 mutations with a number of inflammatory pathologies including Crohn’s disease (CD), graft-versus-host diseases, or Blau syndrome, highlights its pivotal role in inflammatory response and the associated-carcinogenesis development. Since i...
1 CitationsSource