Match!
John C. Mitchell
University of Greenwich
Organic chemistryInorganic chemistryAqueous solutionChemistryChromatography
207Publications
30H-index
3,267Citations
What is this?
Publications 208
Newest
#1Adejumoke Lara Ajiboye (University of Greenwich)H-Index: 1
#2Vivek Trivedi (Medway School of Pharmacy)H-Index: 9
Last. John C. Mitchell (University of Greenwich)H-Index: 30
view all 3 authors...
AbstractThe adsorption of γ-globulin was evaluated with experiments with silica particles marketed as Syloid AL1-FP (SAL), XDP-3150 (SXDP), and 244FP (SFP). The influence of pH, pore sizes, and deg...
Source
#1Vivek TrivediH-Index: 9
#2Ruchir BhomiaH-Index: 4
Last. John C. MitchellH-Index: 30
view all 3 authors...
Solid core drug delivery systems (SCDDS) were prepared for the oral delivery of biomolecules using mesoporous silica as core, bovine haemoglobin (bHb) as model drug and supercritical fluid (SCF) processing as encapsulation technique. The use of organic solvents or harsh processing conditions in the development of drug delivery systems for biomolecules can be detrimental for the structural integrity of the molecule. Hence, the coating on protein-immobilised particles was performed via supercritic...
Source
#1Mohammad Tighsazzadeh (University of Greenwich)
#2John C. Mitchell (University of Greenwich)H-Index: 30
Last. Joshua S. Boateng (University of Greenwich)H-Index: 23
view all 3 authors...
Abstract Thin and erodible polymeric films were developed as potential ocular drug delivery systems to increase drug retention on the eye with the aim of improving bioavailability and achieving controlled drug release. Two biocompatible film forming polymers, hyaluronic acid (HA) and hydroxypropyl methylcellulose (HPMC), which are currently used as thickening agents in eye drops were employed. Two different films were prepared (i) as single polymer and (ii) as composite formulations by solvent c...
Source
#1Dina S. Shokry (University of Greenwich)H-Index: 2
#2Laura J. Waters (University of Huddersfield)H-Index: 19
Last. John C. Mitchell (University of Greenwich)H-Index: 30
view all 4 authors...
Source
#1Dina S. Shokry (University of Greenwich)H-Index: 2
#2Laura J. Waters (University of Huddersfield)H-Index: 19
Last. Martin J. Snowden (University of Greenwich)H-Index: 30
view all 5 authors...
The unique character of bile salts to self-assemble into hydrogels in the presence of halide salts was exploited in this work to facilitate the prediction of human intestinal absorption (%HIA) for a set of 25 compounds. This was achieved by firstly incorporating each compound separately within the process of gel formation to create a series of gel-drug membranes. Scanning Electron Microscopy (SEM) analysis of the freeze-dried samples of the blank bile salt hydrogels and drug loaded bile salt hyd...
1 CitationsSource
#1Dina S. Shokry (University of Greenwich)H-Index: 2
#2Laura J. Waters (University of Huddersfield)H-Index: 19
Last. John C. Mitchell (University of Greenwich)H-Index: 30
view all 4 authors...
Micellar liquid chromatography (MLC) is a popular method used in the determination of a compounds lipophilicity. This study describes the use of the obtained micelle/water partition coefficient (log Pmw) by such a method in the prediction of human intestinal absorption (HIA). As a result of the close resemblance of the novel composition of the micellar mobile phase to that of physiological intestinal fluid, prediction was deemed to be highly successful. The unique micellar mobile phase consisted...
1 CitationsSource
#1Adejumoke Lara Ajiboye (University of Greenwich)H-Index: 1
#2Vivek Trivedi (University of Greenwich)H-Index: 9
Last. John C. Mitchell (University of Greenwich)H-Index: 30
view all 3 authors...
Polycaprolactone (PCL) nanoparticles were produced via supercritical fluid extraction of emulsions (SFEE) using supercritical carbon dioxide (scCO2). The efficiency of the scCO2 extraction was investigated and compared to that of solvent extraction at atmospheric pressure. The effects of process parameters including polymer concentration (0.6–10% w/w in acetone), surfactant concentration (0.07 and 0.14% w/w) and polymer-to-surfactant weight ratio (1:1–16:1 w/w) on the particle size and surface m...
1 CitationsSource
#1Natasa Majcen (University of Greenwich)H-Index: 2
#2Reham Mohsen (University of Greenwich)H-Index: 3
Last. Bojana Voncina (University of Maribor)H-Index: 14
view all 5 authors...
Abstract Colloidal microgels are often described as “smart” due to their ability to undergo quite dramatic conformational changes in response to a change in their environmental conditions (e.g. temperature, pH). A range of novel smart materials were developed by the incorporation of colloidal microgels into cotton fabric. A series of microgels have been prepared by a surfactant free emulsion polymerization based on N-isopropylacrylamide (NIPAM) monomer. Poly(NIPAM) is a thermosensitive polymer w...
Source
#1D. Hooper (University of Greenwich)H-Index: 2
#2F.C. Clarke (Pfizer)H-Index: 2
Last. Martin J. Snowden (University of Greenwich)H-Index: 30
view all 5 authors...
This study demonstrates the effect of active pharmaceutical ingredient (API) particle habit on the sticking propensity of ibuprofen. Four diverse crystal habits with similar physico chemical properties are reported and the sticking propensity was found to increase with shape regularity. The surface energy of the extreme habits were shown to be different where particles that were more regular in shape exhibited surface energies of 9 mJ/m2 higher than those that were needle-like in habit. Computat...
5 CitationsSource
#1Laura J. Waters (Applied Science Private University)H-Index: 19
#2Catherine V. Finch (Applied Science Private University)H-Index: 2
Last. John C. Mitchell (University of Greenwich)H-Index: 30
view all 5 authors...
Abstract This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine, with results indicating that polarity plays an important role in perm...
5 CitationsSource
12345678910