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Xiaohui Liu
Shanghai Jiao Tong University
Molecular biologySUMO proteinZebrafishBiologyCell biology
8Publications
4H-index
48Citations
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Publications 8
Newest
#1Wang L (SJTU: Shanghai Jiao Tong University)H-Index: 6
#2Shuo Gao (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Jun Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 10
view all 13 authors...
Proper cell fate choice of neutrophil-macrophage progenitor is essential for adequate myeloid sub-populations during embryonic development and in adulthood. The network governing neutrophil-macrophage progenitor cell fate is composed of several key determinants such as myeloid master regulators CCAAT enhancer binding protein alpha (C/EBPα) and spleen focus forming virus proviral integration oncogene (PU.1). Nevertheless, more regulators remain to be identified and characterized. To ensure balanc...
1 CitationsSource
#1Yiqin Wang (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Xiaohui Liu (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Jun Zhu (SJTU: Shanghai Jiao Tong University)H-Index: 24
view all 6 authors...
Abstract Hypoxia is widely considered as a limiting factor in vertebrate embryonic development, which requires adequate oxygen delivery for efficient energy metabolism, while nowadays some researches have revealed that hypoxia can induce stem cells so as to improve embryonic development. Erythroid differentiation is the oxygen delivery method employed by vertebrates at the very early step of embryo development, however, the mechanism how erythroid progenitor cell was triggered into mature erythr...
1 CitationsSource
#1Chang Xue (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Xiaohui Liu (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Jun Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 10
view all 7 authors...
A variety of cardiac transcription factors/cofactors, signaling pathways, and downstream structural genes integrate to form the regulatory hierarchies to ensure proper cardiogenesis in vertebrate. Major interaction proteins of the transcription cofactor vestigial like family member 4 (VGLL4) include myocyte enhancer factor 2 (MEF2) and TEA domain transcription factors (TEAD), both of which play important roles in embryonic cardiac development and in adulthood. In this study, we identified that t...
1 CitationsSource
#1Hao Yuan (SJTU: Shanghai Jiao Tong University)H-Index: 6
#2Shuo Gao (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Jun Zhu (SJTU: Shanghai Jiao Tong University)H-Index: 4
view all 6 authors...
TO THE EDITOR: In vertebrates, hematopoietic stem/progenitor cells (HSPCs) first arise from the hemogenic endothelium in the aorta-gonad-mesonephros (AGM) region of the developing embryo[1][1][⇓][2]-[3][3] and subsequently migrate to secondary niches where they expand in number and differentiate
1 CitationsSource
#1Bin Wen (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Hao Yuan (SJTU: Shanghai Jiao Tong University)H-Index: 6
Last. Jun Zhu (SJTU: Shanghai Jiao Tong University)H-Index: 24
view all 8 authors...
Abstract Background SUMOylation is a critical regulatory protein modification in eukaryotic cells and plays a pivotal role in cardiac development and disease. Several cardiac transcription factors are modified by SUMO, but little is known about the impact of SUMOylation on their function during cardiac development. Methods We used a zebrafish model to address the impact of SUMOylation on GATA5, an essential transcription factor in zebrafish cardiac development. GATA5 SUMOylation was probed by we...
4 CitationsSource
#1Hao Yuan (SJTU: Shanghai Jiao Tong University)H-Index: 6
#2Bin Wen (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Jun ZhuH-Index: 50
view all 10 authors...
CCAAT/enhancer-binding protein α (C/ebpα) is a transcription factor that plays important roles in the regulation of hepatogenesis, adipogenesis and hematopoiesis. Disruption of the C/EBPα gene in mice leads to disturbed liver architecture and neonatal death due to hypoglycemia. However, the precise stages of liver development affected by C/ebpα loss are poorly studied. Using the zebrafish embryo as a model organism, we show that inactivation of the cebpa gene by TALENs results in a small liver p...
7 CitationsSource
#1Hao Yuan (SJTU: Shanghai Jiao Tong University)H-Index: 6
#2Tao Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 42
Last. Jun ZhuH-Index: 50
view all 10 authors...
The small ubiquitin-related modifier (SUMO) participates in various cellular processes, including maintenance of genome integrity, nuclear transport, transcription and signal transduction. However, the biological function of sumoylation in hematopoiesis has not been fully explored. We show here that definitive hematopoietic stem/progenitor cells (HSPCs) are depleted in SUMO-deficient zebrafish embryos. Impairment of sumoylation attenuates HSPC generation and proliferation. The hyposumoylation tr...
8 CitationsSource
#1Xiaohui Liu (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Xiao-E Jia (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Jun Zhu (SJTU: Shanghai Jiao Tong University)H-Index: 24
view all 14 authors...
Background: DNA methyltransferase 1 (Dnmt1) regulates expression of many critical genes through maintaining parental DNA methylation patterns on daughter DNA strands during mitosis. It is essential for embryonic development and diverse biological processes, including maintenance of hematopoietic stem and progenitor cells (HSPCs). However, the precise molecular mechanism of how Dnmt1 is involved in HSPC maintenance remains unexplored. Methods: An N-ethyl-N-nitrosourea (ENU)-based genetic screenin...
25 CitationsSource
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