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Bo Zheng
Nanjing Medical University
SpermatogenesisMolecular biologySpermBiologyCell biology
28Publications
9H-index
354Citations
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Publications 29
Newest
#1Tingting Gao (Nanjing Medical University)H-Index: 3
#2Meng Lin (Nanjing Medical University)H-Index: 1
Last. Hongbo Cheng (Nanjing Medical University)H-Index: 2
view all 17 authors...
In males, aging is accompanied by decline in serum testosterone levels due to impairment of testicular Leydig cells. The polycomb protein BMI1 has recently been identified as an anti-aging factor. ...
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#1Dan Zhao (Jiangsu University)H-Index: 2
#2Cong Shen (Nanjing Medical University)H-Index: 4
Last. Bo Zheng (Nanjing Medical University)H-Index: 9
view all 20 authors...
ABSTRACTMyotubularin related protein 7 (MTMR7), a key member of the MTMR family, depicts phosphatase activity and is involved in myogenesis and tumor growth. We have previously identified MTMR7 in ...
1 CitationsSource
#1Xia Chen (Jiangsu University)H-Index: 2
#2Xiaojin Luan (Jiangsu University)H-Index: 2
Last. Jun Yu (Nanjing Medical University)H-Index: 3
view all 17 authors...
The nuclear pre-mRNA spliceosome is a large complex containing five small nuclear ribonucleoprotein particles (snRNPs) and many splicing factors. Messenger RNAs (mRNAs) are generated from pre-mRNAs by the process of RNA splicing, which is conserved in eukaryotes. Precursor RNA processing 3 (Prp3) is a U4/U6-associated snRNP whose function remains largely unknown. In the present study, using genetic manipulation of a Drosophila melanogaster testis model, we demonstrated that Prp3 is essential for...
1 CitationsSource
#1Jun Yu (Jiangsu University)H-Index: 3
#2Qianwen Zheng (Jiangsu University)H-Index: 2
Last. Peifang Yang (Jiangsu University)H-Index: 6
view all 19 authors...
: The aim of the present study was to identify predictive factors for cervical cancer (CC) progression using a multistage approach. The present study obtained data from 390 healthy women and 259 patients with cervical cancer between June 2012 and June 2017, and used a multiple stage re-analysis strategy for clinical detection of CC. A total of seven types of serum indices were used in the present study, including sugar chain antigen 125 (CA-125), sugar chain antigen 199 (CA-199), α fetoprotein (...
1 CitationsSource
#1Jun Yu (Jiangsu University)H-Index: 3
#2Xiaojin Luan (Jiangsu University)H-Index: 2
Last. Jie Fang (Jiangsu University)H-Index: 2
view all 19 authors...
The ribonucleoprotein (RNP) spliceosome machinery triggers the precursor RNA splicing process in eukaryotes. Major spliceosome defects are implicated in male infertility; however, the underlying mechanistic links between the spliceosome and the ribosome in Drosophila testes remains largely unresolved. Small ribonucleoprotein particle protein SmD3 (SmD3) is a novel germline stem cell (GSC) regulatory gene identified in our previous screen of Drosophila testes. In the present study, using genetic ...
3 CitationsSource
#1Jun Yu (Jiangsu University)H-Index: 3
#2Yidan Yan (Jiangsu University)H-Index: 2
Last. Jie Fang (Jiangsu University)H-Index: 2
view all 19 authors...
Self-renewal and differentiation in germline stem cells (GSCs) are tightly regulated by the stem cell niche and via multiple approaches. In our previous study, we screened the novel GSC regulatory gene Srlp in Drosophila testes. However, the underlying mechanistic links between Srlp and the stem cell niche remain largely undetermined. Here, using genetic manipulation of the Drosophila model, we systematically analyze the function and mechanism of Srlp in vivo and in vitro. In Drosophila, Srlp is...
5 CitationsSource
#1Jun Yu (Jiangsu University)H-Index: 3
#2Binghai Chen (Jiangsu University)H-Index: 1
Last. Jie Fang (Jiangsu University)H-Index: 2
view all 16 authors...
: Germ cell maturation is essential for spermatogenesis and testis homeostasis. ATP synthase serves significant roles in energy storage in germ cell survival and is catalyzed by alterations in the mitochondrial membrane proton concentration. The intrinsic cellular mechanisms governing stem cell maturation remain largely unknown. In the present study, in vivo RNA interference (RNAi) screening of major ATP synthase subunits was performed, and the function of ATP synthase for male fertility and spe...
1 CitationsSource
In the past, semen parameters have been the primary diagnostic criteria used to establish male infertility. However, with the exception of sperm motility, which is known to be linked to rates of in vitro fertilization success, these parameters are generally unreliable at accurately predicting the potential fertility of a couple. More recent research has suggested that sperm DNA fragmentation index (DFI) may be a more robust and reliable means of predicting assisted reproductive outcomes.The pres...
#1Jie FangH-Index: 2
#2Bing XieH-Index: 2
Last. Jun YuH-Index: 3
view all 16 authors...
: The incidence of fertile women with missed abortion dramatically increased in recent years, while very few serum indices have been identified for the diagnosis of missed abortion. The aim of this study was to identify related factors for missed abortion through a retrospective study of serum indices.A total of 795 cases of women with missed abortion and 694 cases of women with normal pregnancy between March 2014 and March 2017 were included in the present study. The diagnosis of missed abortio...
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#1Cong Shen (Nanjing Medical University)H-Index: 4
#2Ke Zhang (Nanjing Medical University)H-Index: 1
Last. Bo Zheng (Nanjing Medical University)H-Index: 9
view all 15 authors...
Abstract Stromal interaction molecule 1 (STIM1) is a transmembrane endoplasmic reticulum protein, and it serves as a Ca2+ sensor and activator of store-operated Ca2+ entry (SOCE). We have previously identified STIM1 in the proteome profile of mice neonatal testes, revealing STIM1 to be associated with neonatal testicular development. Here, to further explore the location and function of STIM1 in mice testes, we studied the effect of Stim1 gene knockdown on neonatal testicular development by test...
3 CitationsSource
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