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Bo Zheng
Nanjing Medical University
27Publications
8H-index
250Citations
Publications 27
Newest
Published on Dec 1, 2019in Scientific Reports4.01
Xia Chen1
Estimated H-index: 1
(Jiangsu University),
Xiaojin Luan (Jiangsu University)+ 14 AuthorsZeyu He (PRC: China Medical University (PRC))
The nuclear pre-mRNA spliceosome is a large complex containing five small nuclear ribonucleoprotein particles (snRNPs) and many splicing factors. Messenger RNAs (mRNAs) are generated from pre-mRNAs by the process of RNA splicing, which is conserved in eukaryotes. Precursor RNA processing 3 (Prp3) is a U4/U6-associated snRNP whose function remains largely unknown. In the present study, using genetic manipulation of a Drosophila melanogaster testis model, we demonstrated that Prp3 is essential for...
Published on Oct 18, 2019in Cell Cycle3.26
Dan Zhao1
Estimated H-index: 1
(Jiangsu University),
Cong Shen2
Estimated H-index: 2
(Nanjing Medical University)
+ 17 AuthorsXi Zhang1
Estimated H-index: 1
(Nanjing Medical University)
ABSTRACTMyotubularin related protein 7 (MTMR7), a key member of the MTMR family, depicts phosphatase activity and is involved in myogenesis and tumor growth. We have previously identified MTMR7 in ...
Published on Mar 28, 2019in The FASEB Journal5.39
Jun Yu1
Estimated H-index: 1
(Jiangsu University),
Xiaojin Luan (Jiangsu University)+ 16 AuthorsWanyin Chen1
Estimated H-index: 1
(Jiangsu University)
The ribonucleoprotein (RNP) spliceosome machinery triggers the precursor RNA splicing process in eukaryotes. Major spliceosome defects are implicated in male infertility; however, the underlying mechanistic links between the spliceosome and the ribosome in Drosophila testes remains largely unresolved. Small ribonucleoprotein particle protein SmD3 (SmD3) is a novel germline stem cell (GSC) regulatory gene identified in our previous screen of Drosophila testes. In the present study, using genetic ...
Published on Jun 26, 2019in Oncology Letters1.87
Jun Yu1
Estimated H-index: 1
(Jiangsu University),
Qianwen Zheng (Jiangsu University)+ 16 AuthorsYidan Yan (Jiangsu University)
Published on Apr 1, 2019in Cell Death and Disease5.96
Jun Yu1
Estimated H-index: 1
(Jiangsu University),
Yidan Yan (Jiangsu University)+ 16 AuthorsWanyin Chen1
Estimated H-index: 1
(Jiangsu University)
Self-renewal and differentiation in germline stem cells (GSCs) are tightly regulated by the stem cell niche and via multiple approaches. In our previous study, we screened the novel GSC regulatory gene Srlp in Drosophila testes. However, the underlying mechanistic links between Srlp and the stem cell niche remain largely undetermined. Here, using genetic manipulation of the Drosophila model, we systematically analyze the function and mechanism of Srlp in vivo and in vitro. In Drosophila, Srlp is...
Published on Jan 8, 2019in Molecular Medicine Reports1.85
Jun Yu1
Estimated H-index: 1
(Jiangsu University),
Binghai Chen (Jiangsu University)+ 13 AuthorsCong Shen2
Estimated H-index: 2
(Nanjing Medical University)
Published on Oct 1, 2018in Biochemical and Biophysical Research Communications2.71
Cong Shen2
Estimated H-index: 2
(Nanjing Medical University),
Ke Zhang (Nanjing Medical University)+ 12 AuthorsHongbo Cheng (Nanjing Medical University)
Abstract Stromal interaction molecule 1 (STIM1) is a transmembrane endoplasmic reticulum protein, and it serves as a Ca 2+ sensor and activator of store-operated Ca 2+ entry (SOCE). We have previously identified STIM1 in the proteome profile of mice neonatal testes, revealing STIM1 to be associated with neonatal testicular development. Here, to further explore the location and function of STIM1 in mice testes, we studied the effect of Stim1 gene knockdown on neonatal testicular development by te...
Published on Jul 1, 2018in Reproduction3.13
Bo Zheng8
Estimated H-index: 8
,
Jun Yu1
Estimated H-index: 1
+ 5 AuthorsXiaoyan Huang11
Estimated H-index: 11
Published on Mar 1, 2018in Cell Research17.85
Yiqiang Cui9
Estimated H-index: 9
,
Yuyu Niu15
Estimated H-index: 15
+ 12 AuthorsBo Zheng8
Estimated H-index: 8
Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination
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