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Bo Zheng
Nanjing Medical University
26Publications
9H-index
285Citations
Publications 26
Newest
#1Xia Chen (Jiangsu University)H-Index: 1
#2Xiaojin Luan (Jiangsu University)H-Index: 1
Last.Jun Yu (Nanjing Medical University)H-Index: 1
view all 17 authors...
The nuclear pre-mRNA spliceosome is a large complex containing five small nuclear ribonucleoprotein particles (snRNPs) and many splicing factors. Messenger RNAs (mRNAs) are generated from pre-mRNAs by the process of RNA splicing, which is conserved in eukaryotes. Precursor RNA processing 3 (Prp3) is a U4/U6-associated snRNP whose function remains largely unknown. In the present study, using genetic manipulation of a Drosophila melanogaster testis model, we demonstrated that Prp3 is essential for...
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#1Dan Zhao (Jiangsu University)H-Index: 1
#2Cong Shen (Nanjing Medical University)H-Index: 2
Last.Bo Zheng (Nanjing Medical University)H-Index: 9
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ABSTRACTMyotubularin related protein 7 (MTMR7), a key member of the MTMR family, depicts phosphatase activity and is involved in myogenesis and tumor growth. We have previously identified MTMR7 in ...
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#1Jun Yu (Jiangsu University)H-Index: 1
#2Xiaojin Luan (Jiangsu University)H-Index: 1
Last.Jie Fang (Jiangsu University)H-Index: 1
view all 19 authors...
The ribonucleoprotein (RNP) spliceosome machinery triggers the precursor RNA splicing process in eukaryotes. Major spliceosome defects are implicated in male infertility; however, the underlying mechanistic links between the spliceosome and the ribosome in Drosophila testes remains largely unresolved. Small ribonucleoprotein particle protein SmD3 (SmD3) is a novel germline stem cell (GSC) regulatory gene identified in our previous screen of Drosophila testes. In the present study, using genetic ...
1 CitationsSource
#1Jun Yu (Jiangsu University)H-Index: 1
#2Qianwen Zheng (Jiangsu University)H-Index: 1
Last.Peifang Yang (Jiangsu University)H-Index: 4
view all 19 authors...
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#1Jun Yu (Jiangsu University)H-Index: 1
#2Yidan Yan (Jiangsu University)H-Index: 1
Last.Jie Fang (Jiangsu University)H-Index: 1
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Self-renewal and differentiation in germline stem cells (GSCs) are tightly regulated by the stem cell niche and via multiple approaches. In our previous study, we screened the novel GSC regulatory gene Srlp in Drosophila testes. However, the underlying mechanistic links between Srlp and the stem cell niche remain largely undetermined. Here, using genetic manipulation of the Drosophila model, we systematically analyze the function and mechanism of Srlp in vivo and in vitro. In Drosophila, Srlp is...
1 CitationsSource
#1Jun Yu (Jiangsu University)H-Index: 1
#2Binghai Chen (Jiangsu University)H-Index: 1
Last.Jie Fang (Jiangsu University)H-Index: 1
view all 16 authors...
1 CitationsSource
#1Jie FangH-Index: 1
#2Bing XieH-Index: 1
Last.Jun YuH-Index: 1
view all 16 authors...
Source
#1Cong Shen (Nanjing Medical University)H-Index: 2
#2Ke Zhang (Nanjing Medical University)H-Index: 1
Last.Bo Zheng (Nanjing Medical University)H-Index: 9
view all 15 authors...
Abstract Stromal interaction molecule 1 (STIM1) is a transmembrane endoplasmic reticulum protein, and it serves as a Ca2+ sensor and activator of store-operated Ca2+ entry (SOCE). We have previously identified STIM1 in the proteome profile of mice neonatal testes, revealing STIM1 to be associated with neonatal testicular development. Here, to further explore the location and function of STIM1 in mice testes, we studied the effect of Stim1 gene knockdown on neonatal testicular development by test...
1 CitationsSource
#1Bo ZhengH-Index: 9
#2Jun YuH-Index: 1
Last.Xiaoyan HuangH-Index: 11
view all 8 authors...
2 CitationsSource
#1Yiqiang Cui (Nanjing Medical University)H-Index: 11
#2Yuyu Niu (Kunming University of Science and Technology)H-Index: 17
Last.Weizhi Ji (Kunming University of Science and Technology)H-Index: 25
view all 15 authors...
Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination
13 CitationsSource
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